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Craniofacial Program

Current research

Here are some of the current research interests of the SickKids Centre for Craniofacial Care and Research.

Dr. C. Forrest

Radiation effects on bone growth
Read more about the research of Dr. C. Forrest

Dr. C. Pang

Skin pathophysiology and pharmacology:  We investigate: (i) The role and mechanism of neurohumoral substances and cytokines released by blood and endothelial cells in local regulation of skin perfusion; and (ii) The efficacy and mechanism of endothelial growth factor and nitric oxide synthase gene therapy in prevention/mitigation of skin ischemia in small and large animal models.

Muscle pathophysiology and pharmacology:   We use muscle flaps in large animal models to investigate the mechanism and application of ischemic preconditioning in prevention of skeletal muscle ischemia/reperfusion injury in surgery.

Wound healing:  We investigate the pathogenic mechanism and intervention of radiotherapy-induced impaired wound healing.

Our research offers the potential for the identification of therapeutic agents/techniques for prevention and/or treatment of skin and muscle vasospasm and ischemia/reperfusion injury in surgical trauma and prevention of radiotherapy-induced impaired wound healing.

Read more about the research of Dr. C. Pang