Research activities
Dermatology Research Activities
The Section of Dermatology is currently involved in several research studies from retrospective studies to randomized controlled, prospective studies.
The main areas of research focus are:
- Epidermolysis Bullosa
- Intervention trials
- Outcome measures
- Vascular tumors
- Intervention trials
- Cutaneous T-cell lymphoma
- Prospective cohort studies
- Morphea (localized scleroderma)
- Outcome measures
Active Clinical Research Projects
International registry of paediatric cutaneous T-cell lymphoma: a longitudinal, prospective, observation study of cutaneous T-cell lymphoma in the paediatric population. Pope E, Weinstein M, Weitzman S, Taylor G
Presentation, management and outcomes evaluation of children with vascular tumours. (Vascular Tumor Registry). Pope E, Mahant S, Blanchette V, Weitzman S, Baruchel S, John P, Brandao L
Development of ultrasound and clinical disease activity measures for pediatric localized scleroderma. Pope E, Li S, Laxer R, Doria A
Nadalol for Proliferating Infantile Hemangiomas: A prospective open label study. Pope E, Chakkittakandiyil A, Weinstein M, Baruchel S
Development and Evaluation of Outcome Measures in Patients with Epidermolysis Bullosa. Pope E, Schwieger-Briel A
Clonality of T Cells in Peripheral Blood of Children with Cutaneous Lymphomas: a cohort pilot study. Pope E, Weitzman S, Zeller J, Chakkittakandiyil A, Alexander S, Abdelhaleem M, Ngan B
A Randomized, Controlled, Multidose, Multicentre, Adaptive Phase II/III Study in Infants with Proliferating Infantile Hemangiomas Requiring Systemic Therapy to Compare Four Regimens of Propanolol (1 or 3 mg/kg/day for 3 or 6 months) to Placebo (double blind). Pope E, Chakkittakandiyil A, Lara-Corrales I
Vitamin D Deficiency in Pediatric Patients with Atopic Dermatitis and Psoriasis: Prevalence and Risk Factors. Pope E, Lara-Corrales I
Selected Publications
Ho NTC, Lansang P, Pope E: Topical imiquimod in the treatment of infantile hemangiomas: A retrospective study. Journal of the American Academy of Dermatology 2007: 56(1): pp 63-68. CPA
Pope E, Krafchik BR, Macarthur C, Stempak D, Stephens D, Weinstein M, Ho N, Baruchel S: Oral versus high dose pulse corticosteroids for problematic infantile hemangiomas: a randomized controlled trial. Pediatrics 2007: 119(6): pp 1239-1247. PA
Lam J, Pope E: Pediatric pityriasis lichenoides and cutaneous T-cell lymphoma. Current Opinion in Pediatrics 2007: 19(4): pp 441-445. SRI
Metry DW, Siegel DH, Cordisco, MR, Pope E, Prendiville J, Drolet BA, Horii KA, Stein SL, Frieden IJ: A comparison of disease severity among affected male versus female patients with PHACE syndrome. The Journal of the American Academy of Dermatology 2008: 58 (1): pp 81-87. C
Lara-Corrales I, Pope E: Epidermolysis bullosa: The pediatrician's role. Current Pediatric Reviews 2008: 4 (4): pp 250-7. CPA
6. Drucker A, Pope E, Mahant S, Weinstein M: Vincristine and Corticosteroids as First-line Treatment of Kasabach-Merritt Syndrome in Kaposiform Hemangioendothelioma. Journal of Cutaneous Medicine and Surgery 2009: 13(3): pp 155-9. CPA
Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, Laxer R, Tedgard U, Cowen EW, Pham TH, Booty M, Estes JD, Sandler NG, Plass JA, Schneider R, Babyn P, El-Shanti HI, Pope E, Barron K, Bing X, Laurence A, Lee CC, Chapelle D, Clarke GI, Ohson K, Nicholson M, Gadina M, Yang B, Korman BD, Gregersen PK, van Hagen PM, Hak AE, Huizing M, Rahman P, Douek DC, Remmers EF, Kastner DL, Goldbach-Mansky R: An Autoinflammatory Disease with Deficiency of the interleukin-1 receptor antagonist. New England Journal of Medicine 2009: 360 (23): pp 2426-2437. C
Metry D; Garzon M; Drolet B; Frommelt P; Haggstrom A; Hall J; Hess C; Heyer G; Siegel D; Baselga L; Katowitz W; Moise L; Mancini A; Maronn M; Phung T; Pope E; Sun G; Frieden IJ: PHACE Syndrome: Current Knowledge, Future Directions. Pediatric Dermatology 2009: 26 (4): pp 381-398. CPA
Arkachaisri T, Vilaiyuk S, Li S, O'Neil KM, Pope E, Higgins GC, Punaro M, Rabinovitch EC, Rosenkranz M, Kietz DA, Rosen P, Spalding SJ, Hennon TR, Torok KS, Cassidy E, Medsger Jr TA; Localized Scleroderma Clinical and Ultrasound Study Group: The localized scleroderma skin severity index (LoSSI) and Physician Global Assessment of Disease Activity: A work-in-progress toward the development of localized scleroderma outcome measures. Journal of Rheumatology 2009: 36(12): pp 2819-2829. CPA
Pope E, Weitzman S, Ngan B, Walsh S, Morel K, Williams J, Stein S, Garzon M, Knobler E, Lieber C, Turchan K, Wargon O, Tsuchiya A: Mycosis Fungoides in the Pediatric Population: Report from an International Childhood Registry of Cutaneous Lymphoma. Journal of Cutaneous Medicine and Surgery 2010: 14 (1): pp 1-6. PA
Ryan C, Price V, John P, Mahant S, Baruchel S, Brandao L, Blanchette V, Pope E, Weinstein M: Kasabach-Merritt phenomenon: a single centre experience. European Journal of Haematology 2010: 84 (2): pp 97-104. C
Lara-Corrales I, Pope E: Principles of Wound Care in Patients with Epidermolysis bullosa. Pediatric Dermatology 2010 May: 27(3):229-37. CPA
Lara-Corrales I, Pope E: Dilated Cardiomyopathy in Epidermolysis Bullosa. Dermatologic Clinics 2010: 28: 347-351. CPA
Pope E: Epidermolysis Bullosa Care in Canada. Dermatologic Clinics 2010: 28: 391-392. PA
Lo V, Lara-Corrales I, Stuparich A, Pope E: Amniotic membrane grafting in epidermolysis bullosa patients with chronic wounds. Journal of American Academy of Dermatology 2010: 62(6): 1038-1044. SRI
Chakkittakandiyil A, Pope E: Topical Timolol Gel for Infantile Hemangiomas - A Pilot Study. Archives of Dermatology 2010 May: 146(5): 564-5. PA
Lara-Corrales I, Mellerio JE, Martinez AE, Green A, Lucky AW, Azizkhan RG, Murrell DF, Agero AL, Kantor PF, Pope E: Dilated Cardiomyopathy in Epidermolysis Bullosa. A retrospective, multicenter study. Pediatric Dermatology 2010 May: 27(3): 238-243. SRI
Lara-Corrales I, Arbuckle A, Zarinehbaf S, Pope E: Principles of Wound Care in Patients with Epidermolysis Bullosa. Pediatric Dermatology 2010 May: 27(3): 229-237. SRI
Palmero ML, Uziel Y, Laxer RM, Forrest CR, Pope E: En Coup de Sabre Scleroderma and Parry Romberg Syndrome in Adolescents: Surgical Options and Patient Related Outcomes. Journal of Rheumatology 2010 Oct; 37(10): 2174-9. PMID: 20843909. SRI. Erratum in J Rheumatol 2010 Nov; 37 (11): 2444
Yeung M, Balma-Mena A, Shear N. Simor A, Pope E, Walsh S, McGavin MJ: Identification of Major Clonal Complexes and Toxin Producing Strains among Staphylococcus aureus Associated with Atopic Dermatitis. Microbes Infect. 2010 Nov 18: epub ahead of print. PMID: 21093604. C
Self-Funded Research Endeavours
Pope E, Aujla N
The psychosocial implications of patients living with epidermolysis bullosa. .
Pope E, Lansang P, Weinstein M.
Growth outcomes for infants with hemangiomas treated with oral corticosteroids.
Pope E, Luca N, Lara-Corrales I.
Factors predictive of admission in eczema herpeticum.
Pope E, Chakkittakandiyil, A.
Timolol Maleate Gel for Infantile Hemangiomas - A Retrospective Study.
Pope E, Mahant S, Blanchette V, Weitzman S, Baruchel S, John P, Brandao L
Presentation, management and outcomes evaluation of children with vascular tumours. (Vascular Tumor Registry). Paediatric Consultants, The Hospital for Sick Children
Weinstein M, Armstrong K.
Periungual granulation tissue growth during Isotretinoin therapy.
Shouldice M, Weinstein M, Wentzel K
Genital HPV in children.
Pope E, Aujla N.
EB Focus Group: The Psychosocial Implications of Patients Living with Epidermolysis Bullosa
Research - Endowments
Epidermolyis Bullosa Endowment Fund, Section of Dermatology. Krafchik B, Pope E
Wagner Dermatology Research Endowment Fund, Section of Dermatology. Pope E