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Research activities

Dermatology Research Activities

The Section of Dermatology is currently involved in several research studies from retrospective studies to randomized controlled, prospective studies.

The main areas of research focus are:

  1. Epidermolysis Bullosa
    • Intervention trials
    • Outcome measures
  2. Vascular tumors
    • Intervention trials
  3. Cutaneous T-cell lymphoma
    • Prospective cohort studies
  4. Morphea (localized scleroderma)
    • Outcome measures

Active Clinical Research Projects

International registry of paediatric cutaneous T-cell lymphoma: a longitudinal, prospective, observation study of cutaneous T-cell lymphoma in the paediatric population.  Pope E, Weinstein M, Weitzman S, Taylor G

Presentation, management and outcomes evaluation of children with vascular tumours. (Vascular Tumor Registry).  Pope E, Mahant S, Blanchette V, Weitzman S, Baruchel S, John P, Brandao L

Development of ultrasound and clinical disease activity measures for pediatric localized scleroderma.  Pope E, Li S, Laxer R, Doria A

Nadalol for Proliferating Infantile Hemangiomas: A prospective open label study.  Pope E, Chakkittakandiyil A, Weinstein M, Baruchel S

Development and Evaluation of Outcome Measures in Patients with Epidermolysis Bullosa.  Pope E, Schwieger-Briel A

Clonality of T Cells in Peripheral Blood of Children with Cutaneous Lymphomas: a cohort pilot study.  Pope E, Weitzman S, Zeller J, Chakkittakandiyil A, Alexander S, Abdelhaleem M, Ngan B

A Randomized, Controlled, Multidose, Multicentre, Adaptive Phase II/III Study in Infants with Proliferating Infantile Hemangiomas Requiring Systemic Therapy to Compare Four Regimens of Propanolol (1 or 3 mg/kg/day for 3 or 6 months) to Placebo (double blind).  Pope E, Chakkittakandiyil A, Lara-Corrales I

Vitamin D Deficiency in Pediatric Patients with Atopic Dermatitis and Psoriasis: Prevalence and Risk Factors. Pope E, Lara-Corrales I

Selected Publications

Lara-Corrales I, Xi N, Pope E: Childhood Psoriasis Treatment: evidence published over the last 5 years.  Rev Recent Clin Trials. 2011 Jan: 6(1): 36-43.  PMID: 20868348.  SRI/C

Yeung M, Balma-Mena A, Shear N. Simor A, Pope E, Walsh S, McGavin MJ: Identification of Major Clonal Complexes and Toxin Producing Strains among Staphylococcus aureus Associated with Atopic Dermatitis. Microbes Infect. 2011 Feb: 13(2): 189-97.  PMID: 21093604.  

Lam J, Lara-Corrales I, Cammisuli S, Somers GR, Pope E: Primitive Myxoid Mesenchymal Tumour of Infancy in a Preterm Infant.  Pediatric Dermatology. 2010 Nov-Dec: 27 (6): 635-7.  PMID: 21078111

Al Hawsawi K, Pope E: Yellow Nail Syndrome.  Pediatric Dermatology.  2010 Nov - Dec: 27(6): pp 675-76.  PMID 21510012. 

Balma-Mena A, McGavin M, Zeller J, Lara Corrales I, Richardson S, Weinstein M, Pope E: Colonization with Community Acquired Methicillin-Resistant Staphylococcus aureus in Children with Atopic Dermatitis: a Cross Sectional Study.  International Journal of Dermatology, 2011 Jun 50(6): 682-8.  PMID 21595661.

Al Hawsawi K, Pope E: Pediatric Psychocutaneous Disorders: a review of primary psychiatric disorders with dermatological manifestations.  American Journal of Clinical Dermatology, 2011 Aug 1: 12(4): 247-57.    PMID 21548659.  

Ho NTC, Pope E, Weinstein M, Greenberg S, Webster C, Krafchik B: A double-blind, randomized, placebo-controlled trial of topical tacrolimus 0.1% vs. clobetasol propionate 0.05% in childhood vitiligo.
British Journal of Dermatology, 2011 Sept: 165(3): 626-32. PMID 21457214

Fain ET, Mannion M, Pope E, Young DW, Laxer RM, Cron RQ: Brain Cavernomas Associated with En Coup de Sabre Linear Scleroderma: two case Reports. Pediatric Rheumatology Online Journal 2011 Jul 29: 9(1):18.  PMID: 21801349  

Balma A, Weinstein M, Rosenthal A, Henry P, Gahzarian D, Miller J, Maul E, McGuirl J, Moorthy L:  Index of Suspicion * Case 1: Pruritic, Erythematous, Papular, and Papulovesicular Rash in an 8-year-old * Case 2: Cough With Green Phlegm in an 8-year-old * Case 3: Polyarthritis, Raynaud Phenomenon, Hoarseness, Tapering Fingers, and Digital Ulcers in a 6-year-old. Pediatric Review 2011 Aug 32(8): 353-8

Finkelstein Y, Soon GS, Acuna P, George M, Pope E, Ito S, Shear N, Koren G, Shannon M, Garcia-Bournissen F: Recurrence and outcomes of Stevens-Johnson Syndrome and toxic epidermal necrolysis in Children. Pediatrics 2011 Oct: 128(4):723-8.  PMID: 21890829

Chakkittakandiyil A, Phillips R, Frieden IJ, Siegfried E, Lara-Corrales I, Lam J, Bergmann J, Bekhor P, Poorsattar S, Pope E: Timolol Maleate 0.5% or 0.1% Gel-Forming Solution for Infantile Hemangiomas: A Retrospective, Multicenter, Cohort Study.  Pediatric Dermatology.  2012 Jan-Feb. 29(1): 28-31.  PMID 22150436

Lara-Corrales I, Parkin PC, Stephens D, Hamilton J, Koren G, Weinstein M, Sibbald G, Pope E: The Efficacy of Trimethoprim in Wound healing of Patients with Epidermolysis bullosa: a feasibility trial.  Journal of American Academy of Dermatology.  Journal of American Academy of Dermatology.  2012 Feb; 66(2): 264-70.  

Pope E, Doria A, Theriault M, Mohanta A, Laxer R: Topical Imiquimod 5% Cream for Pediatric Plaque Morphea: A Prospective, Multiple-Baseline, Open-Label Pilot Study. Dermatology 2011;223 (4):363-369.             PMID 22327486  

Mirsky L, Chakkittakandiyil A, Laxer R, O’Brien C, Pope E: Relapse after Systemic Treatment in Pediatric Morphea.  British Journal of Dermatology.  2012 Feb; 166(2): 433-5.  

Pope E, Lara-Corrales I, Mellerio JE, Martinez AE, Schultz G, Burrell R, Goodman L, Coutts P, Wagner J, Allen U, Sibbald RG: A Consensus Approach to Wound Care in Epidermolysis Bullosa. Journal of American Academy of Dermatology.  2012 Nov; 67 (5): 904-17.  PMID 22387035.  

Kazem S, van der Meijden E, Kooijman S, Rosenberg AS, Hugley LC, Browning JC, Sadler G, Busam K, Pope E, Benoit B, Fleckman P, deVries E, Eekhof JA, Feltkamp MC.  Trichodysplasia spinulosa is characterized by active polyomavirus infection.  Journal of Clinical Virology. 2012 Mar; 53 (3): 225-30     PMID 22196870

Li S, Taroq K, Pope E, Dedeoglu F, Hong S, Jacobe H, Egla Rabinovich C, Laxer RM, Higgins GC, Lasky A, Baszis K, Becker M, Campillo S, Cartwright V, Cidon M, Inman CJ, Jerath R, O’Neil KM, Vora S, Zeft A, Wallace CA, Ilowite NT, Fuhlbrigge RC: Development of Consensus Treatment Plans for Juvenile Localized Scleroderma.  Arthritis Care & Research (Hoboken); 64(8); pp 1175-85.  2012 Aug.   PMID 22505322  

Luca N, Lara-Corrales I, Pope E: Eczema Herpeticum in Children: Clinical Features and Factors Predictive of Hospitalization.  Journal of Pediatrics. Journal of Pediatrics. 2012 Oct; 161 (4): 671-5.  PMID 22575249  

Drolet BA, Pope E, Juern A, Sata A, Howell B, Brown Puttgen K, Lara-Corrales I, Gilliam A, Mancini A, Powell J, Siegel D, Metry D, Frieden IJ: Gastrointestinal Bleeding in Infantile Hemangioma: a complication of Segmental, rather than Multifocal Infantile Hemangioma. Journal of Pediatrics.  2012 Jun; 160 (6): 1021-1026.e3        PMID 22240112   

Siegel DH, Tefft KA, Kelly T, Johnson C, Metry D, Burrows P, Pope E, Cordisco M, Holland KE, Moheshwari M, Keith P, Garzon M, Hess C, Frieden IJ, Fullerton HJ, Drolet BA: Stroke in Children with Posterior Fossa Brain Malformations, Hemagiomas, Arterial Anomalies, Coarctation of the Aorta and Cardiac defects, and Eye Abnormalities (PHACE) Syndrome: A Systemic Review of the Literature. Stroke.  2012 Jun; 43(6): 1672-4  PMID 22442177  

Chiu YE, Drolet B, Blei F, Carcao M, Fangusaro J, Kelly ME, Krol A, Lofgren S, Mancini AJ, Metry DW, Recht M, Silverman RA, Tom WL, Pope E: Variable response to Propanolol treatment of kaposiform hemangioendothelioma, tufted angioma, and Kasabach-Merritt phenomenon.  Pediatric Blood & Cancer. 2012 Nov; 59(5): 934-8. PMID 22648868  

Balma-Mena A, Chakkittakandiyil A, Weinstein M, Lansang P, Ho N, Cammisuli S, Pope E. Propranolol in the management of infantile hemangiomas: clinical response and predictors. J Cutan Med Surg. 2012 May-Jun;16(3):169-73.  PMID: 22713439.  

Pope E, Chakkittakandiyil, Lara-Corrales I, Maki E, Weinstein M: Expanding the therapeutic repertoire of infantile hemangiomas: Cohort blinded study of oral Nadolol compared with Propanolol. British Journal of Dermatology.   British Journal of Dermatology.  2013 Jan; 168 (1): 222-4.  PMID 22575249   

Chad L, Dubinski W, Hawkins C, Pope E, Bernstein S, Chiasson D.  Post-Mortem Vascular Pathology in PHACES Syndrome: A Case Report. Pediatric and Developmental Pathology. 2012 Nov-Dec; 15(6):507-10. PMID 22901051. 

Siegel DH, Shieh JT, Kwon EK, Baselga E, Blei F, Cordisco M, Dobyns WB, Garzon MC, Gibbs DL, Grimmer JF, Hayflick SJ, Krol AL, Kwok PY, Lorier R, Matter A, McWeeney S, Metry D, Mitchell S, Pope E, Santoro JL, Stevenson DA, Bayrak-Toydemir P, Wilmot B, Worthey EA, Frieden IJ, Drolet BA, Broeckel U: Copy Number Variation Analysis in 98 Individuals with PHACE Syndrome.  J Invest Dermatol. 2012 Oct 25.  Epub ahead of print. PMID 23096700.  

Sherlock ME, Walters T, Tabbers MM, Frost K, Zachos M, Muise K, Pope E, Griffiths AM: Infliximab-Induced Psoriasis and Psoriasiform Skin Lesions in Pediatric Crohn’s Disease and a Potential Association with Il-23 Receptor Polymorphisms.  Journal of Pediatric Gastroenterology Nutrition. 2012 Dec 27.  Epub ahead of print. PMID 23274341.  

Bergman J, Weinstein M: Common Dermatological Problems in the Paediatric Office. CPS Today. 2012 Jun 6-9; pp 3-5.

Thomas R, Landells I, Lynde C, Withers M, Weinstein M, Kunynetz R, Haber R, Balbul A, Dion P-L: Canadian Consensus on Skin Barrier Therapy in Atopic Dermatitis.  Journal of Cutaneous Medicine and Surgery. 2012 Mar/Apr; 16 (suppl 1): S1-16.  

Self-Funded Research Endeavours

Pope E, Aujla N
The psychosocial implications of patients living with epidermolysis bullosa. .

Pope E, Lansang P, Weinstein M.
Growth outcomes for infants with hemangiomas treated with oral corticosteroids.

Pope E, Mahant S, Blanchette V, Weitzman S, Baruchel S, John P, Brandao L
Presentation, management and outcomes evaluation of children with vascular tumours. (Vascular Tumor Registry). Paediatric Consultants, The Hospital for Sick Children

Lara-Corrales I, Mohammed J
Neurofibromatosis type I, Juvenile Xanthogranuloma & Malignancy

Shouldice M, Weinstein M, Wentzel K
Genital HPV in children.

Pope E, Aujla N.
EB Focus Group: The Psychosocial Implications of Patients Living with Epidermolysis Bullosa

Lara-Corrales, Garcia Romero M
Segmental or Mosaic neurofibromatosis in Pediatrics: a case series

Laxer R, Twilt M, Pope E, Blaser S, Forrest C, O’Brien C.
New Imaging Findings in Localized Morphea Scleroderma in patients.  

Pope E, Lara-Corrales I, Lee M. 
Epidermolysis Bullosa Clinical Characterization and Outcomes Database.  

 Pope E, Randhawa H, Weinstein M, Lara-Corrales I. 
Duration of Therapeutic Effect if Oral Nadolol for Treatment of Infantile Hemangiomas – a retrospective comparative study. 

 Pope E, Randhawa H, Weinstein MG, Branson H, Blaser S.  
Risk of Neurocutaneous Melanosis in Pediatric Patients with Congenital Melanocytic Nevi.

 Pope E, Rubio Gomez G, Weinstein MG.  
Development of a Disease Severity Score for Patients Born with Collodion Membrane. 

Laxer R, Pope E, O’Brien C, Boydell K.
Exploring the Lived Experiences of Children with Facial Morphea.  

Research - Endowments

Epidermolyis Bullosa Endowment Fund, Section of Dermatology. Krafchik B, Pope E

Wagner Dermatology Research Endowment Fund, Section of Dermatology. Pope E