Current Studies in Diagnostic Imaging
Registry of 18F-Fluorodeoxyglucose (18F-FDG) Positron Emission Tomography and Computed Tomography (PET/CT) Scans Performed to Evaluate Cancer in Children
Dr. Amer Shammas, The Hospital for Sick Children
A PET scan, or Positron Emission Tomography scan, is an imaging technique that allows physicians to examine many organs of the body. It is helpful in diagnosing many diseases, such as cancer, and can detect small amounts of tumour that might be missed by other types of radiology exams. Other imaging techniques, such as CT scan or MRI, only show organ structure, where as PET shows organ structure and function.
During a PET scan, a patient receives an injection of a small amount of radioactive glucose (sugar) into their bloodstream. In this study FDG is used. It is already known that PET scans are useful in evaluating certain tumours and in evaluating children who are suspected of having these tumours.
The goal of this study is to find out exactly how accurate PET scans are, when compared to other kinds of scans that have been used for a longer time (for example CT scan, MRI, and Gallium scans). PET scans will be compared to other imaging tests patients have had (such as CT, MRI, or nuclear medicine scans) to assess how accurately PET detects disease compared to these other tests. A patient registry will be created from data gathered from these scans and entered into a database that will allow further studies to be conducted in the future.
The aim is to create a registry of patients who are undergoing 18F-FDG PET/ CT at The Hospital for Sick Children (SickKids), in order to demonstrate the clinical utility of 18F-FDG PET/CT in Canadian children. The creation of a patient registry will enable us to perform effective retrospective analyses on the diagnostic performance, including sensitivity, specificity and accuracy of 18F-FDG PET/CT in the diagnosis and localization/staging of tumours and in the monitoring of response to therapy. Comparison in diagnostic performance can be made to conventional imaging modalities such as stand-alone CT, MRI, and other nuclear medicine examinations.
Patients who are eligible for this study are SickKids patients with a known, or suspected, diagnosis of cancer and a clinical indication for 18F-FDG PET/CT.
November, 2009 - Present
Dr. Amer Shammas
The Hospital for Sick Children