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Diagnostic imaging
Diagnostic Imaging

Current Studies in Diagnostic Imaging

Imaging Cell Proliferation with FLT PET: A Pilot Study in Paediatric Lymphoma Patients with Equivocal FDG PET Findings

Investigators

Dr. Amer Shammas, The Hospital for Sick Children

Dr. Dan Costantini, Research Fellow, The Hospital for Sick Children

Description

This is a pilot study evaluating the clinical use of FLT PET in paediatric patients with Hodgkin’s lymphoma (HL). FLT is a radioisotope called 3'-Deoxy-3'-[F-18] fluorothymidine.  

This study will determine whether FLT PET is feasible as a follow-up imaging technique in paediatric HL patients whose FDG PET scan results were questionable. This pilot study will yield sufficient preliminary data to help design a larger study of FLT PET in paediatric HL patients. Positron emission tomography (PET) is a type of imaging which shows organ function and has been useful in distinguishing between malignant and benign tumours when CT and MRI have been unable to prove whether a tumour is malignant or benign.

Objectives

The primary objective of this study is to assess the likelihood of using FLT PET imaging to obtain an additional scan to compare with the FDG PET scan to see if the FLT is able to pick up any tumour activity that the FDG PET scan did not.  The pathology result, and clinical and imaging follow-up will used to determine the sensitivity, specificity and accuracy of FLT PET.

Eligibility

SickKids patients with a known diagnosis of HL who had an inconclusive FDG PET/CT scan after two cycles of therapy or upon completion of therapy and in whom it is not possible resolve the exam results using other conventional imaging techniques such as CT or MRI.  

Ten participants will be recruited onto this study.

Timeline

Starting May 2011 to December 2011

Contact Information

Dr. Amer Shammas
Phone: 416-813-6089

Funding

Internal Nuclear Medicine Funding