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Neurosurgery
Neurosurgery

Spotlight on Neurosurgery


TRACING SINGLE BRAIN CANCER CELLS SIMPLIFIES COMPLEXITY OF INCURABLE BRAIN CANCERS

Using an innovative barcode-like system that tracks the behaviour of individual brain cancer cells, an international research team has gained a new understanding of how glioblastoma brain cancers grow and has identified potential new ways of treating these incurable cancers

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12 NEW SUBTYPES OF OF MEDULLOBLASTOMA DISCOVERED

In 2010, scientists at The Hospital for Sick Children (SickKids) in Toronto discovered that it was actually composed of four different subgroups, each with its own molecular composition and clinical characteristics.

Now, researchers from SickKids and around the world have found these four subgroups separate further into a dozen different subtypes the researchers are calling “the dirty dozen”. These subtypes exhibit different clinical behaviour, marking a significant step forward towards developing personalized treatment for children with medulloblastoma. The study was published in the June 12 edition of Cancer Cell.

The study was co-led by Drs. Michael Taylor, Ramaswamy and Goldenberg and involved an international team of 95 researchers including first authors Dr. Florence Cavalli from SickKids and Dr. Marc Remke from the University of Düsseldorf. 

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PARKINSON'S DISEASE MAY BE A KEY TO SOLVING THE GLIOBLASTOMA PUZZLE

As the most common and aggressive cancerous brain tumour in adults, a glioblastoma diagnosis remains a death sentence due to its  resistance to all currently-available treatments. 

Research in this area has been slow and steady to date. Now, with promising new findings, a Canadian team of scientists is ushering brain cancer research into a new realm: the field of neurodegenerative medicine and neurochemical signalling.

“This research opens a door – it sets a new proof of principle in thinking about cancer in the brain and how it’s growing,” says the study’s principal investigator, Dr. Peter Dirks.

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