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Division of Orthopaedics


Simple Bone Cysts in Kids (SBoCK)

Sponsor:  Dr. James G. Wright and The Hospital for Sick Children (Canada)

Funding: Canadian Institutes for Health Research (CIHR) - 
Musculoskeletal Health and Arthritis

Participating Institutions:

    • NYU Hospital for Joint Diseases (US)
    • Connecticut Children's Medical Center (US)
    • Nemours – Alfred I duPont Hospital for Children (US)
    • Ann & Robert H. Lurie Children’s Hospital of Chicago (US)
    • Texas Children's Hospital (US)
    • Children's Hospital of Alabama/University of Alabama at Birmingham (US)
    • Nemours Research Institute – Florida (US)
    • Shriners Hospitals for Children – Honolulu (US)
    • BC Children's Hospital (Canada)
    • IWK Health Centre (Canada)
    • Great Ormond Street Hospital for Children (UK)
    • London Health Science Centre (Canada)
    • Sidra Medical and Research Center (Qatar)
    • CHU de Nancy (France)
    • Good Samaritan Hospital (US)
    • Hospital for Special Surgery (US)

Collaborators at The Hospital for Sick Children:

    • Dr. Sevan Hopyan
    • Dr. Andrea Doria
    • Dr. Paul Babyn
    • Dr. Jennifer Stimec

The Trial

Funded by the Canadian Institutes for Health Research (CIHR), this international, multicentre, randomized clinical trial, led by Dr. James G. Wright at The Hospital for Sick Children will evaluate the effectiveness of two surgical procedures commonly used in clinical practice for the treatment of simple bone cysts in children.  

Most patients with a SBC present due to pain or pathologic fracture.  These lesions frequently interfere with function, dramatically restrict play activity, cause re-fracture possibly leading to growth arrest and/or deformity, and result in enormous anxiety for children and their families. While many forms of treatment have been recommended for simple bone cysts, little evidence exists to show which treatment most reliably eradicates the cyst.

The objectives of this trial are:

    1. To compare the rate of radiographic healing between two standard treatments for SBCs including curettage with puncture alone, and curettage with puncture followed by injection with Vitoss morsels.
    2. To identify prognostic radiographic factors associated with SBC healing and fracture.
    3. To determine the impact of SBCs on children/family functioning.

For more information please visit the study website at http://www.sickkids.ca/Research/SBoCK/index.html