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Rickets

Definition

Rickets is a metabolic bone disease of the growing bone in children evidenced by changes in serum biochemistry and decreased mineralization of the growth plates and diaphyses.

Common Symptoms

Children may complain of bone pain and weakness, present with fractures, seizures, delay in growth and development and or skeletal deformities.  
Most commonly rickets is due to a deficiency of Vitamin D.   It may also be due to one of the forms of hypophosphatemic rickets( most common form is X-Linked hypophosphamemic rickets).  Less often rickets may be result from Calcium deficiency. 

Suggested Investigations

Blood work: Calcium (total and ionized), Phosphate, 25(OH) Vit D, Alk Pi, PTH, creatinine, serum pH, electrolytes (Na,K,Cl), glucose,  1,25(OH)2  Vit D

Randomt Urine:   Ca/Cr ratio

Radiology: Rickets Survey 

Diagnosis

The diagnosis is based on serum biochemistry and X ray findings that are consistent with rickets

Refer to the Calcium Clinic for diagnosis.

Rickets caused by vitamin D metabolism disorders other than D deficiency

Hypophosphatemic  Rickets

Calcium Deficiency Rickets