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Arthur & Sonia Labatt Brain Tumour Research Centre

Mixed neuronal-glial tumours

ganglioglioma image

 

Gangliocytoma and ganglioglioma
Tumours composed of neoplastic, mature ganglion cells, either alone (gangliocytoma) or in combination with neoplastic glial cells (ganglioglioma). Histologically gangliocytoma corresponds WHO grade I while ganglioglioma may be of grade I or II or even grade III (anaplastic ganglioglioma).Tumours occur throughout the CNS including cerebrum, brain stem, cerebellum, spinal cord, optic nerves, pituitary gland and pineal gland. The majority is supratentorial and involves the temporal lobe.

 

Desmoplastic infantile astrocytoma and ganglioglioma
Large tumours involve superficial cortex and leptomeninges, are mostly attached to dura and occur in infants, with a general good prognosis following surgery. These tumours consist of a prominent desmoplastic stroma with a neuroepithelial populations mainly restricted to astrocytes in desmoplastic cerebral astrocytoma of infancy (DCAI) and to astrocytes together with a variable neuronal component in desmoplastic infantile ganglioglioma (DIG).