Facebook Pixel Code
Arthur & Sonia Labatt Brain Tumour Research Centre

Alumni 2004

Shigeo Ueda

Dr. Shigeo Ueda, MD
I began as a research fellow in J.T. Rutka's laboratory in December 2002. I am currently in my sixth year of residency in the department of neurosurgery at the Saga Medical School in Japan. I graduated from the Saga Medical School in 1998. During my first three years of clinical training, I developed an interest in neuro-oncology and basic science research and, as such, I entered into a Ph.D. program under the supervision of Prof. K. Tabuchi.

My neuro-oncology research in Japan centered on the understanding of the regulation of MGMT expression. It is an important DNA repair gene and plays a critical role as a chemotherapy resistance factor for commonly used brain tumour treatments such as nitrosourea compounds (BCNU, ACNU etc.). A friend and fellow resident from Saga Medical School, Kohata, was in Rutka's Laboratory for 2 years. He constantly encouraged me to study here, as it is one of the most productive and prestigious institutes for basic neuro-oncology research.

I am currently studying the function the novel gene, human Costal-2 as it applies to the pediatric brain tumour medulloblastoma. It is known as a negative regulator of the Hedgehog signal transduction pathway and holds much potential in the further understanding of how this pathway contributes to medulloblastoma oncogenesis. I hope that my efforts in this project will be fruitful and contribute to the continuing success of the BTRC.

Michael Carter

Dr. Michael Carter, MD
I hail from London, England. I graduated in medicine from the University of Southampton, in 1988. I spent a number of years training in General Surgery and gained surgical Fellowships from the Royal Colleges in London and Edinburgh in 1995. Having seen the light, I entered the Neurosurgical training programme at the Wessex Neurological Centre in 1996, graduating in 2001 after gaining the Intercollegiate Fellowship in Neurological Surgery. I graduated from the joint European course in neurosurgery the same year. I came to SickKids as the Rittersporn clinical Fellow in paediatric neurosurgery for the 2002-2003 period.

My research interests include the history of UK neurosurgery, non-invasive measurement of intracranial pressure and the genetics of paediatric CNS tumours. I spent 18 months in the Wessex Regional Genetics laboratory in Salisbury, UK investigating chromosomal imbalances in ependymal tumours using the technique of Comparative Genomic Hybridization.

I am currently undertaking a further research fellowship at the BTRC investigating the significance of chromosome 1 imbalance as a prognostic marker in paediatric ependymoma.

John Kuo

Dr. John Kuo, MD, PhD
My research in the Rutka lab focuses on developing new diagnostic and therapeutic strategies for medulloblastoma based on a novel tumour-specific gene, OPL.

Prior studies showed that OPL is an evolutionarily conserved protein expressed in cerebellar granule cells and specific to medulloblastomas. PCR-based subtractive cloning is being used to identify OPL-regulated genes that could shed light on tumorigenesis, and may yield new therapeutic targets.

I am also developing a clinical OPL test for detecting disease progression, and am collaborating on work to identify other molecular markers relevant for medulloblastoma diagnosis and treatment. All of these projects are made possible by the confluence of a terrific mentor, synergy with colleagues and a wealth of clinical resources here at the BTRC and The Hospital for Sick Children. Before my fellowship here in Toronto, I trained at the University of Southern California in Neurological Surgery, and earned my medical and graduate degrees at Harvard Medical School and MIT.