Facebook Pixel Code
Arthur & Sonia Labatt Brain Tumour Research Centre

Alumni 2005

Frederieke Rutten

Frederieke Rutten - Visiting Student
I have been conducting research at the Arthur and Sonia Labatt Brain Tumour Research Centre (BTRC) since January of 2004 under the supervision of James Rutka.

I am 23 years old and have been in medical school for four years. I am attending school in Groningen, a city in the north of The Netherlands. One of the requirements for graduation at my medical school is a research project. Through my supervisor in The Netherlands I got in contact with Rutka and he welcomed me to come to Toronto to do my project at the BTRC.

My research project is about Verotoxin and the treatment of medulloblastoma. Verotoxin is a toxin produced by the E. Coli bacteria and known to be a possible novel anti-neoplastic agent for certain cancers. I am trying to find out of Verotoxin could be a possible new agent in the treatment of medulloblastoma. I am also assisting a PhD student at Rutka's lab. Her research is about the role of GTPases in the migration of cells.

When I get back in Holland I will begin my two years of rotations. After finishing that, I hope to start my PhD and residency and may become a neurosurgeon.

Takuichiro Hide

Dr. Takuichiro Hide, MD
I have been working in Peter Dirks' laboratory since April of 2003. I graduated from Kumamoto University School of Medicine (Japan) in 1991 and worked in Kumamoto. In medical school my majors were Neurosurgery and soccer.

I have studied head development since my postgraduate school days. The title of my work was "Genetic modifiers of otocephalic phenotypes in Otx2 heterozygous mutant mice" (Development 129: 4347-4357, 2002). Using the severity of the phenotype that depended on the genetic background of a C57BL/6 (B6) strain, we found two modifiers that account for the distribution of craniofacial malformations, known as otocephaly or agnathia-holoprosencephaly complex, by the genetic effect between B6 and CBA strains.

My specialty is Paediatric Neurosurgery. I would like to study more using my experience of research of developmental biology to advantage. I had been looking for a chance to study in The Hospital for Sick Children. Fortunately Dirks gave me an opportunity to perform research at the BTRC. We research the mechanisms of tumorigenesis from "brain tumour stem cells" and "neural stem cells". The projects of our laboratory are very suited to me. I enjoy working everyday and appreciate that Dirks gave me the opportunity to study here.

Amit Ray

Dr. Amit Ray, MD
I graduated from Medical School in India and came to the United Kingdom soon after. Once I completed my four year basic surgical training rotation I passed the Royal College exam and was admitted as a fellow of The Royal College of Surgeons in general surgery in 1997. I entered higher surgical training in Neurosurgery in 1998 and am currently in the 5th year of a six year training program.

As a resident, I was trained in all aspects of neurosurgery and developed an interest in paediatric neurosurgery and epilepsy surgery. Realizing that better understanding of the basic principals of molecular biology was essential in understanding tumour biology I began looking for a fellowship where I could combine both clinical and laboratory interests. I was told by my senior colleagues to write to Dr James Rutka as The Hospital for Sick Children and The Brain Tumour Research Centre is probably the only place in the world where such a fellowship would be possible. Keeping alive the long tradition of British neurosurgeons who have visited SickKids, I arrived in Dec 2002 for a two-year period, hoping to combine work in the laboratory with some clinical experience.

Currently I am working in the BTRC exclusively, on using tissue microarray technology to identify new prognostic molecular markers in medulloblastoma and on SUFU, a suppressor of the hedgehog pathway, which had been shown undergo mutations in medulloblastoma. I hope to start my clinical fellowship next year.