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Bear Lab

Kidney Disease Research

Mutations in ClC-5, a chloride/proton antiporter causes Dent’s disease – a disease which is associated with proteinuria and renal failure in severe cases. The goal of our research is to understand how ClC-5 contributes (in a complex of other transporters and signaling proteins) to effective protein reabsorption by the kidney. Further, we will define the molecular basis for the renal pathology associated with disease-causing mutations in ClC-5 and identify protein targets for therapeutic intervention.

These kidney-disease related studies are supported by:

The Kidney Foundation of Canada