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Centre for Complex Childhood Diseases

Centre for the Study of Complex Childhood Diseases

The completion and operation of the Centre for the Study of Complex Childhood Diseases (CSCCD) with its five core facilities, funded by the Canada Foundation of Innovation (CFI), has been a primary focus for the Translational Medicine Research Program at the SickKids Research Institute. This state-of-the-art research facility enables whole body, physiological, pharmacological, neurological and nutritional metabolic translation research for complex childhood diseases including: rare disease cohorts, complex care, transplant, cystic fibrosis (CF), asthma and sleep disorders. This new infrastructure support enables researchers to create new research capacity, including a state-of-the-art patient-based research unit, imaging research facilities for animals and human subjects, as well as analytical infrastructure for drug and metabolite analysis of biological fluids.

The CSCCD consists of :

  • Clinical Research Centre (CRC): formerly known as the Physiological Research Unit (PRU), the centre supports and enables high quality and safe research on human participants, including healthy control subjects and those with chronic disease. Learn more
  • Animal Physiology Investigation Unit (APRU): a multipurpose lab equipped for physiological assessments of the heart, digestive, respiratory and circulatory systems of small animals. Learn more
  • Analytical Facility for Bioactive Molecules (AFBM): a state-of-the-art laboratory equipped for multiplex bead technology, high-performance liquid chromatography (HPLC) and mass spectrometry for exploratory drug/metabolite analysis. Learn more
  • Human Tissue Culture and  Biorepository (HTCB): a modern facility equipped to process and derive primary cell isolates as well as human stem cells for further development in vitro and pre-clinical research models.
  • Research MRI Facility: available for use by research projects involving phantoms, animal modes of disease, and human participants, from newborns to adults. Learn more

SickKids is one of the few institutions in the world capable of hosting an initiative as visionary and as comprehensive as the CSCCD. The CSCCD has become critical for the translation of research discoveries into improvements in the care of children afflicted with complex diseases.