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Facilities and Resources

Facilities and Resources

In order to provide for the wide array of infrastructure requirements of our research community, we are home to a series of specialized scientific core facilities. Each of these facilities provides technical expertise and services as well as access to state-of-the art equipment to our researchers on a cost recovery basis.

For more information on these facilities and the variety of services that are available, visit the links below.

The Canadian Mouse Mutant Repository (CMMR)
The CMMR is a central repository for the cryopreservation and archiving of mutant mouse lines as spermatozoa, embryos and tissues in various formats (fixed, embedded and glass-slide mounted). The CMMR is also the repository and distribution centre for mutant mouse embryonic stem cells from the North American Conditional Mouse Mutagenesis project (NorCOMM). Located at the The Centre for Phenogenomics (TCP), the CMMR forms part of a full-service mouse model research centre.

The Centre for Applied Genomics (TCAG)
TCAG provides genomics services to scientists worldwide. The core is comprised of a cluster of facilities that provide resources, technologies and expertise essential for gene-based disease research and other basic and applied genetic and genomic investigations. Their facilities provide state-of-the-art services in the following areas: DNA Sequencing/Synthesis; Microarray Analysis; Cytogenomics and Genome Resources; Genetic Analysis; Statistical Analysis; Biobanking and databases.

The Centre for Computational Medicine (CCM)
The CCM provides essential Bioinformatics and High Performance Computing services to the SickKids Research Institute and the global research community. Their services include High-Throughput Sequencing data analysis, Bioinformatics software development and consulting,  as well as supercomputing services. CCM hosts the High Performance Computing Facility (HPF), which supports cutting-edge research by providing high-performance computing access, up-to-date biological datasets and applications and consultative expertise to academic and private-sector clients. The CCM also acts as a collaboration nexus, connecting SickKids researchers and clinicians with computational scientists at the University of Toronto. 

Centre for the Study of Complex Childhood Diseases (CSCCD)
The CSCCD is a state-of-the-art research facility that enables whole body, physiological, pharmacological, neurological and nutritional metabolic translation research for complex childhood diseases including: rare disease cohorts, complex care, transplant, cystic fibrosis (CF), asthma and sleep disorders. It is made up of the following facilities: the Physiological Research Unit (PRU), the Animal Physiology Investigation Unit (APRU), the Analytical Facility for Bioactive Molecules (AFBM), the AFBM Biorepository and the Research MRI Facility.

Flow and Mass Cytometry Facility (FMCF)
The joint SickKids/UHN Flow and Mass Cytometry facility, located in the PGCRL and the TMDT, provides access to analytical flow cytometers and high-speed cell sorters. FMCF staff operate and maintain the analytical cytometers and cell sorters, assist researchers in protocol selection and development, and will train students, post-doctoral fellows and technologists how to operate the analytical cytometers and use the data analysis software. 

Imaging Facility
The Imaging Facility provides a full range of biological imaging solutions for life sciences research. The facility contains a vast array of the latest technologies in biological imaging, which are made available to both academia and industry on a cost recovery basis. They also provide (mandatory) training on their full range of acquisition, accessory and analysis systems. 

Nanoscale Biomedical Imaging Facility
The Nanoscale Biomedical Imaging Facility offers state-of-the-art equipment and technical expertise in a user-friendly environment. This joint venture between SickKids and Mount Sinai Hospital provides microscopy services to scientists at SickKids, Mount Sinai, the University of Toronto and the scientific community at large.

Research MEG
The Research Magnetoencephalography (MEG) Facility provides the SickKids Research Institute and local scientists access to a non-invasive functional neuroimaging technique that allows investigation of human brain activity on a millisecond timescale.

SPARC BioCentre
The SPARC BioCentre is an amalgamation of analytical platforms assembled to provide researchers at SickKids and beyond with state of the art services related to molecular analysis and design.  The SPARC BioCentre operates on a fee-for-service basis, and is operated by an experienced professional staff that can participate in your projects all the way from early consultation and planning phases, through to the delivery of data, data analysis, and the preparation of publications and grant proposals. 

Structural & Biophysical Core Facility
The Structural & Biophysical Core (SBC) Facility is a shared instrument facility specializing in biophysical methods for investigating biomolecular structure, dynamics, stability, and interactions. The tools are particularly valuable for studying proteins, including folded soluble and membrane proteins and intrinsically disordered proteins; their interactions with binding partners; and their self-association, such as in phase-separated states. The facility serves scientists from the Research Institute of The Hospital for Sick Children (SickKids), external academic institutions and industry. The equipment is accessed through pay-per-use fees or yearly membership. Users of the facility are supported by full-time personnel that provide instrument and experimental assistance

The Centre for Phenogenomics/The Mouse Imaging Centre (MICe)
The Centre for Phenogenomics (TCP)/Mouse Imaging Centre (MICe) is a state of the art facility enabling ground-breaking research with expertise in mouse generation, breeding and maintenance, phenocombines digital imaging technologies for the characterization of mouse models of human disease and phenotype discovery. The result of an innovative collaboration between Mount Sinai Hospital, St. Michael’s Hospital, The Hospital for Sick Children, the University Health Network and the University of Toronto, Faculty of Medicine, the TCP provides research support for researchers from member institutions, throughout Ontario and around the world.

TCP Transgenic Core (TCP Tg Core)
TCP is a state-of-the-art facility enabling ground-breaking research with expertise in mouse generation, breeding and maintenance, phenotypic analysis, pathology and cryopreservation. The result of an innovative collaboration among Mount Sinai Hospital, St. Michael’s Hospital, The Hospital for Sick Children, the University Health Network and the University of Toronto, Faculty of Medicine, the TCP provides research support for researchers from member institutions, throughout Ontario and around the world.

Zebrafish Core Facility
The Zebrafish Genetics and Disease Models Facility uses the expertise and infrastructure available at SickKids to generate and analyze zebrafish models of human disease. Transparent embryos, rapid early development and large clutch sizes make zebrafish suitable both for quick, in vivo testing of human gene mutations and for high-throughput drug screening. Our goal is to provide high quality, cost effective mutation generation, phenotyping and other custom services necessary to produce zebrafish models of human disease.