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Guidos Lab
Guidos Lab

Lymphoblastic Development

Subversion of Survival and Developmental Pathways in Acute Lymphoblastic Leukemia

guidos lab group

Leukemias and lymphomas, like all cancers, arise when cells reproduce unrestrainedly due to mutations in genes that control cell division, differentiation, survival or programmed cell death.

Our research program is designed to probe the developmental steps and mechanisms of leukemo- and lymphomagenesis in mouse models and in humans. We are working collaboratively within a specialized centre of leukemia research to validate the findings obtained from murine model systems, cell lines and primary human leukemia cells to determine how our findings can improve the diagnosis and prognosis of leukemia.

Our specific areas of interest are: 1) intracellular signalling pathways that govern cell survival, differentiation or death fate decisions in normal and neoplastic lymphoid cells, 2) identification and analysis of the leukemia inititating cell(s), or leukemia stem cells, that initiate and sustain the leukemic clone to understand how genes and molecular pathways operate in leukaemic initiation and progression, and 3) how leukemic blasts can survive and expand in the central nervous system (CNS) causing a major clinical complication of leukemia and lymphomas.

The long-term objective of this program is to functionally translate knowledge gained in mouse and cell line model systems to primary human leukemia, to provide evidence to inform future clinical trials.

Experimental approaches:
Mouse models, primary human leukemia and lymphoma cells, flow cytometry, molecular cytogenetics, gene expression microarrays, comparative genomic hybridization, lentiviral mediated gene transduction, NOD-SCID xenotransplantation.

Positions available: Positions are available for graduate students, and post-doctoral fellows with appropriate background and expertise.

Collaborators:

Funding support: