Guidos lab
Welcome to the Laboratory of Dr. Cynthia Guidos, PhD
- Professor, University of Toronto, Department of Immunology
- Senior Scientist, The Hospital for Sick Children Research Institute, Developmental & Stem Cell Biology Program
- Scientific Director, The Flow Cytometry Facility,The Hospital for Sick Children
- Principal Investigator, Leukemia Research Group, The Hospital for Sick Children
Dr. Guidos established her independent research program at The Hospital for Sick Children Research Institute in 1991. She is currently a senior scientist in the Developmental & Stem Cell Biology program at the SickKids Research Institute, and is also a professor of Immunology in the Faculty of Medicine at the University of Toronto. After obtaining her PhD in Medical Sciences (Immunology) from the University of Alberta (1986), Dr. Guidos completed a postdoctoral fellowship with Dr. Irving Weissman at Stanford University (1986-91).
While at Stanford she identified several novel precursor-progeny relationships during murine intrathymic T cell development. These studies provided the impetus for establishing her independent research program, which is focused on elucidating molecular mechanisms that regulate survival, proliferation, and lineage commitment during lymphocyte development. Defects in this process are known to cause lymphoblastic leukemia and immune deficiency. Dr. Guidos’ current research is focused on two broad goals:
1) To elucidate essential functions of the Notch signaling pathway in T and B cell development
2) To elucidate mechanisms of T and B cell leukemogenesis, by identifying pathways that allow T and B cell progenitors to escape death, proliferate and self-renew aberrantly