Neurosciences & Mental Health

Neurosciences & Mental Health

Head: Dr. Michael Salter

The Neurosciences & Mental Health program (NMH) focuses on the brain and the nervous system in health and disease. Led by Program Head Dr. Michael Salter, our diverse group of researchers includes international leaders in the field of neurosciences and mental health. We investigate both normal development and disorders of the nervous system from a broad range of perspectives in a highly collaborative and interactive environment. The investigators in our program examine the role of genes, proteins and other molecules in brain function to determine the different causes of brain dysfunction and ultimately to develop novel therapies and prevention strategies that substantially improve a child’s quality of life at home, in school and within their environments.

Some current NMH research studies:

  • Developmental and pathological neuroplasticity and neuron-glia interactions
  • Development of sensory systems and pain
  • Cognitive function and dysfunction in model organisms and children
  • Inherited and acquired central nervous system disorders in model organisms and children
  • Functional neuro-imaging and cognitive neuroscience in children
  • Complex neurogenetics disorders, such as, ADHD, autism and learning disabilities
  • Design of (EMPOWER®) program to address the core cognitive barriers that prohibit children from becoming successful readers 

DNA methylation in parental genomes

In the February 17, 2012 issue of Cell, researchers at SickKids, Toronto Western Hospital and the Ludwig Institute for Cancer Research at the University of California, San Diego describe how differential DNA methylation in parental genomes contributes to selective expression of imprinted genes in the mouse brain. Cathy Barr, a senior scientist at SickKids is a co-author of the paper. view abstract

Did You Know?

The International Union of Basic and Clinical Pharmacology (IUPHAR) has formulated nomenclature recommendations for ligand-gated ion channels to help standardize classification of the major receptor and ion channel systems in the human genome. Read more