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Obesity in Youth History

Publications

Publications and Presentations

McCrindle BW, Manlhiot C, Millar K, Gibson D, Stearne K, Kilty H, Prentice D, Wong H, Chahal N, Dobbin SW. Population trends toward increasing cardiovascular risk factors in Canadian adolescents. J Peds 2010; 157(5):837-843

Obesity Related Publications by Team Members

Wells GD, Noseworthy MD, Hamilton J, Tarnopolski M, Tein I: Skeletal muscle dysfunction in obesity and metabolic syndrome.  Can Journal of Neurol Sci 2008; 35:31-40   

Retnakaran R, Shen S, Hanley A, Vuksan V, Hamilton J, Zinman B: Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test. Obesity2008; 16(8):1901-1907

Buccino J, Daneman D, Hamilton J: Nutrition education program design for children with Type 2 diabetes mellitus.  Can J Diet Pract Res 2008; 69(4):192-197   

Rottembourg D, O’Gorman C, Urbach S, Garneau PY, Langer J, Van Vliet G, Hamilton J, Huot C:  Outcome after bariatric surgery in two adolescents with hypothalamic obesity following treatment of craniopharyngioma.  J Pediatr Endocrinol Metab 2009; 22(9):867-872    

Simoneau-Roy J, O’Gorman C, Pencharz P, Adeli K, Daneman D, Hamilton J: Insulin sensitivity and secretion in children and adolescents with hypothalamic obesity following treatment for craniopharyngioma.  Clin Endocrinol 2010; 72(3):364-370

Retnakaran R, Qi Y, Goran M, Hamilton J: Evaluation of proposed oral disposition index measures in relation to the actual disposition index.  Diabetic Medicine 2009; 26(12):1198-1203    

Hamilton J, Odrobina E, Junlang, Y, Hanley A, Zinman B, Retnakaran R: Maternal insulin sensitivity during pregnancy predicts infant weight gain and adiposity at 1 year of age. Obesity 2010; 18(2):340-346

Rakhshani N, Jeffery A, Schulte F, Barrera M, Atenafu E, Hamilton J: Evaluation of a comprehensive care clinic model for children with brain tumor and risk for hypothalamic obesity. Obesity 2010;  18(9):1768-1774  

Amed S, Dean H, Panagiotopoulos C, Sellers E, Hadjiyannakis S, Laubscher T, Dannenbaum D, Shah B, Booth G, Hamilton J:  Type 2 diabetes, medication induced diabetes, and monogenic diabetes in Canadian children: a prospective national surveillance study.  Diabetes Care 2010; 33(4):786-791  

Obadia M, Rakhshani N, Jeffery A, Chahal N, Sangha G,  McCrindle BW, O’Connor D, Maccarone T, Hamilton J: MEALTRAIN: What do inpatient hospitalized children choose to eat?. J Peds 2010; 156(4):685-686

Clodagh S, O’Gorman C, Simoneau-Roy J, Pencharz P, MacFarlane J, MacLusky I, Narang I, Adeli K, Daneman D, Hamilton J: Sleep disordered breathing is increased in obese adolescents with craniopharyngioma compared with obese controls.  J Clin Endocrinol Metab 2010; 95(5):2211-2218.  

SCIENTIFIC PRESENTATIONS

Primary Care  

Birken C, McCrindle B, Beck C, Mekky M,  Jacobson S, Peer M, Taylor C, Manlhiot C, Smith K,    Parkin P:  Predictors of screen time in 3 year old children: the Media Use in Preschooler study. Pediatric Academic Societies Annual Meeting, May 2009, Baltimore, MD  

Birken C, McCrindle B, Beck C, Mekky M,  Jacobson S, Peer M, Taylor C, Manlhiot C, Smith K,   Parkin P:  TARGet Kids! A randomized controlled trial to reduce screen time in preschoolers in the physician office setting: the Media Use in Preschoolers Study. Canadian Pediatric Society, June 2009, Ottawa, ON & Pediatric Academic Societies Annual Meeting, May 2009, Baltimore, MD

Maguire J, Birken C, Mekky M, Jacobson S, Peer M, Parkin P: Does bottle use at 2 years of age predict increased media viewing time? a TARGet Kids! study. Canadian Pediatric Society, June 2009, Ottawa, ON & Pediatric Academic Societies Annual Meeting, May 2009, Baltimore, MD

Maguire J, Mekky M, Jacobson S, Peer M, Taylor C, Parkin P: Prevalence and predictors of vitamin D deficiency in urban Canadian toddlers: a TARGet Kids! study. Canadian Pediatric Society, June 2009, Ottawa, ON & Pediatric Academic Societies Annual Meeting, May 2009, Baltimore, MD

Maguire J, Mekky M, Jacobson S, Peer M, Taylor C, Parkin P: Randomized controlled trial of an educational intervention to reduce bottle use in children 9 months to 2 years of age: a TARGet Kids! study.Canadian Pediatric Society, June 2009, Ottawa, ON & Pediatric Academic Societies Annual Meeting, May 2009, Baltimore, MD

Maguire J, Mekky M, Jacobson S, Peer M, Taylor C, Parkin P: The effect of anticipatory guidance on healthy milk intake and iron stores in the real world: a TARGet Kids! study of integrated knowledge translation.  Canadian Pediatric Society, June 2009, Ottawa, ON & Pediatric Academic Societies Annual Meeting, May 2009, Baltimore, MD

Li K, Birken C, Maguire J, Mekky M, Burr L, O’Connor DL, Chisamore B, Lau E, Parkin P: TARGet Kids! measuring nutrition risk in young preschool-aged children in the primary care practice setting. Canadian Pediatric Society, June 2009, Ottawa, ON & Pediatric Academic Societies Annual Meeting, May 2009, Baltimore, MD  

Fernandes N, Taylor G, Manlhiot C, McCrindle BW, Ho M, Miner SES, Jaeggi ET, Nield LE: The myocardium of fetuses with endocardial fibroelastosis contains a paucity of B and T lymphocytes compared with normal controls. American College of Cardiology, March, 2010, Atlanta, GA  

Abdullah K, Maguire JL, Birken CS, Khovratovich M, Manlhiot C, McCrindle BW, Parkin P: Temperament as a predictor of nutrition risk in pre-school children. Annual Meeting of the Pediatric Academic Societies, May, 2010, Vancouver, BC

Birken CS, Maguire J, Abdullah K, Khovratovich M, Manlhiot C, McCrindle BW, Parkin P: Temperament as a predictor of screen time in pre-school children: a TARGet Kids! study. Pediatric Academic Societies Annual Meeting, May, 2010, Vancouver, BC

Birken CS, Maguire J, Hamilton J, Khovratovich M, Manlhiot C, McCrindle BW, Parkin P: Nutritional risk is associated with cholesterol levels in preschool children in primary care practice: a TARGet Kids! study. Pediatric Academic Societies Annual Meeting, May, 2010, Vancouver, BC

Birken CS, Maguire J, Hamilton J, Khovratovich M, Manlhiot C, McCrindle BW, Parkin P:  The influence of the family meal on nutritional risk and obesity in healthy preschool children: a TARGet Kids! study. Pediatric Academic Societies Annual Meeting, May, 2010, Vancouver, BC

Birken CS, Maguire J, Hamilton J, Khovratovich M, Manlhiot C, McCrindle BW, Parkin P: Waist circumference is associated with nutritional risk and BMI in preschool children in primary care practice. Pediatric Academic Societies Annual Meeting, May, 2010, Vancouver, BC

Birken CS, Maguire J,  Khovratovich M, Manlhiot C, McCrindle BW, Parkin P: Predictors of screen time in preschool children: a TARGet Kids! study. Pediatric Academic Societies Annual Meeting, May, 2010, Vancouver, BC

Maguire J, Birken CS, Khovratovich M, Manlhiot C, McCrindle BW, Parkin P:  Is prolonged bottle use associated with child temperament? - a TARGet Kids! study. Pediatric Academic Societies Annual Meeting, May, 2010, Vancouver, BC

Maguire J, Birken CS, Khovratovich M, Manlhiot C, McCrindle BW, Parkin P:  Bottle use, obesity and iron depletion: a TARGet Kids! study. Pediatric Academic Societies Annual Meeting, May, 2010, Vancouver, BC

Maguire J, Birken CS, Khovratovich M, Manlhiot C, McCrindle BW, Parkin P: Prolonged bottle use and nutrition risk: a TARGet Kids! study. Pediatric Academic Societies Annual Meeting, May, 2010, Vancouver, BC

Maguire J, Birken CS, Khovratovich M, Manlhiot C, McCrindle BW, Parkin P: The association between prolonged bottle use and screentime: a TARGet Kids! study. Pediatric Academic Societies Annual Meeting, May, 2010, Vancouver, BC

Specialty Care

Chu L, Schneiderman J, McCrindle BW, Riddell M, Hamilton J: Influence of puberty on fat oxidation rates during exercise in overweight boys and girls.  Ontario Exercise Physiology Conference, January 22-24, 2010, Barrie, ON

Syme C, Hamilton J, Noseworthy MD, Schneiderman JE, Wilkes DL, Wells GD: Muscle mitochondrial function is associated with physical activity and not obesity status in youth. Muscle Health Awareness Day, York University, May 28, 2010, Toronto, ON

Syme C, Wells GD, Detzler G, Cheng HLM, McCrindle BW, Hamilton J: Metabolic correlates of hepatic and pancreatic fat in overweight youth. Canadian Obesity Network Student Annual Meeting, June 9-12, 2010, Ottawa, ON

Syme C, Hamilton J, Noseworthy MD, Schneiderman JE, Wilkes DL, Wells GD: Muscle mitochondrial function is associated with physical activity and not obesity status in youth. Canadian Obesity Network Student Annual Meeting, June 9-12, 2010, Ottawa, ON

Syme C, Wells GD, Detzler G, Cheng HLM, Noseworthy MD, Schirmer T, McCrindle BW, Hamilton J: Pancreatic and hepatic fat and associated metabolic complications in overweight youth. International Society for Magnetic Resonance in Medicine, May 1-7, 2010, Stockholm, Sweden  

Detzler G, Syme C, Cheng HLM, Noseworthy MD, Schirmer T, Wells GD, Hamilton J: Comparison of 1H-MRS and in-and out-of-phase imaging to measure hepatic fat. Society for Magnetic Resonance Technologists, May 1-7, 2010, Stockholm, Sweden

Chu L, Hamilton J, Schneiderman JE, McCrindle BW, Riddell MC: Fat oxidation rates during exercise in obese pre-and post-pubertal boys and girls. Canadian Obesity Network Student Annual Meeting, June 9-12, 2010, Ottawa, ON

Patel BP,Anderson GH, Bellissimo N, Pencharz PB, McCrindle BW, Hamilton JK: Satiety hormone and subjective appetite responses after a mixed glucose and whey protein beverage in overweight and obese children and adolescents.  Physiology & Experimental Medicine Scientific Retreat, The Hospital for Sick Children Research Institute, March 10, 2010, Toronto, ON  

Chu L, Riddell M, Hamilton J: A pilot project on the influence of pubertal development on fat oxidation rates during exercise in overweight girls.  The Hospital for Sick Children Research Institute Summer Student Research Program Scientific Day, July 2009, Toronto, ON

Darmawikarta D, Chu L, McCrindle BW, Riddell M, Hamilton J: Evaluating levels of physical activity in obese boys and girls using accelerometry.  The Hospital for Sick Children Summer Student Research Day, July 2010, Toronto, ON (Winner: Outstanding poster presentation)  

Deforest M, Syme CA, Detzler G, Cheng HLM, McCrindle BW, Hamilton J: Evaluation of hepatic and pancreatic fat in obese children and adolescents using magnetic resonance imaging.  Charles Hollenberg Summer Student Research Day. August 9, 2010, Toronto, ON  

Syme C.A, Wells GD, Detzler G, Cheng HLM, McCrindle BW, Hamilton J: Hepatic and pancreatic fat and associated metabolic parameters in overweight youth.  International Society for Paediatric and Adolescent Diabetes Annual Meeting, October 27-31, 2010, Buenos Aries, Argentina  

CityWide Pediatric Rounds, May 2009:  Pharmacotherapy of childhood obesity.

The Hospital for Sick Children Paediatric Update Conference, May 2009:  I want a new drug:  pharmacotherapy of childhood obesity.

The Hospital for Sick Children Gynecology Rounds, March 2010:  Management of obesity in children and adolescents.

The Hospital for Sick Children Foundation Lunch and Learn, May 2010:  Size matters.  

Accepted Abstracts

Birken CS, Maguire JL, Khovratovich M, Wu YY, Mamdani M, McCrindle BW, Parkin P, TARGet Kids!, HISTORY teams:  Inactive transport: stroller use and physical activity in preschool children: a TARGet Kids! study.  Canadian Obesity Network 2nd National Obesity Summit, April 28-May 1, 2011, Montreal, QC

Birken CS, Maguire JL, Khovratovich M, Wu YY, Hamilton J, Hanley A, Adeli M, Mamdani M, McCrindle BW, Parkin P:  Preschoolers at risk: obesity and cardiometabolic factors.  A TARGet Kids! study. Canadian Obesity Network 2nd National Obesity Summit, April 28-May 1, 2011, Montreal, QC

Syme CA, McCrindle BW, Hamilton J: Cardiometabolic risk associated with waist/height and BMI z-score in overweight youth. Canadian Obesity Network 2nd National Obesity Summit, April 28-May 1, 2011, Montreal, QC

Core  

McCrindle BW, Manlhiot C, Millar K, Gibson D, Stearne K, Kilty H, Prentice D, Wong, H, Chahal N, Dobbin S: Cross-sectional trends in cardiovascular risk factors in grade 9 students: the Heart Niagara screening program 2002-2008. Annual Meeting of the Canadian Cardiology Society, October 2009, Edmonton, AB  

Manlhiot C, Shalabi M, Dobbin SW, Gibson D, Chahal N, Wong H, Stearne K, Makerewich O, Fisher A, Davies J, McCrindle BW: Association between sleep and cardiovascular risk factors in adolescents. Canadian Cardiovascular Conference, October 23-27, 2010, Montreal, QC

Khoury M, Manlhiot C, Dobbin S, Gibson D, Chahal N, Wong H, Davies J, Stearne K, Makerewich O, Fisher A, McCrindle BW: The association of cardiovascular risk and high body mass index in adolescents is influenced by waist circumference.Canadian Cardiovascular Conference, October 23-27, 2010, Montreal, QC

Accepted Abstracts

McCrindle BW, Manlhiot C, Gibson D, Chahal N, Wong, H,  Stearne K, Makerewic O, Fisher, A, Davies J,  Dobbin SW:  Population-based lipid screening in the era of a childhood obesity epidemic: the importance of non-HDL cholesterol assessment. Canadian Obesity Network 2nd National Obesity Summit 2011, April 28-May 1, 2011, Montreal, QC  

Banks L, Manlhiot C, Davies J, Wong H, Gibson D, Chahal N, Stearne K, Fisher A, Makerewich O,  Dobbin SW, McCrindle BW:  Cardiovascular risk in overweight and obese adolescents: is there an influence of physical activity. Canadian Obesity Network 2nd National Obesity Summit 2011, April 28-May 1, 2011, Montreal, QC

Davies J, Manlhiot C, Wong H, Gibson D, Chahal N, Stearne K, Fisher A, Makerewich O, Dobbin SW, Narang I, McCrindle BW:  The association between sleep disturbances and obesity in adolescents may be mediated by increased consumption of caffeinated beverages. Canadian Obesity Network 2nd National Obesity Summit 2011, April 28-May 1, 2011, Montreal, QC

Obadia M, Boydell K, Dettmer E, Parkin P, Birken C, McCrindle BW:  Perspectives of parents of obese children regarding physician management of childhood obesity. Canadian Obesity Network 2nd National Obesity Summit, April 28-May 1, 2011, Montreal, QC

General Obesity

Han JC, Lawlor DA,  Kimm SYS. Childhood obesity. The Lancet. 2010 May; 375(9727): 1737-1748.

Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. Risk factors and adult body mass index among overweight children: the Bogalusa Heart Study. Pediatrics. 2009 Mar;123(3):750-7.  

Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. Inter-relationships among childhood BMI, childhood height, and adult obesity: the Bogalusa Heart Study. Int J Obes Relat Metab Disord. 2004 Jan;28(1):10-6.

Han E, Truesdale KP, Taber DR, Cai J, Juhaeri J, Stevens J. Impact of overweight and obesity on hospitalization: race and gender differences. Int J Obes (Lond). 2009 Feb;33(2):249-56. Epub 2009 Jan 20.  

Li L, Law C, Lo Conte R, Power C. Intergenerational influences on childhood body mass index: the effect of parental body mass index trajectories. Am J Clin Nutr. 2009 Feb;89(2):551-7. Epub 2008 Dec 23.

Neovius M, Sundström J, Rasmussen F. Combined effects of overweight and smoking in late adolescence on subsequent mortality: nationwide cohort study. BMJ. 2009 Feb 24;338:b496.

van Gerwen M, Franc C, Rosman S, Le Vaillant M, Pelletier-Fleury N. Primary care physicians' knowledge, attitudes, beliefs and practices regarding childhood obesity: a systematic review. Obes Rev. 2009 Mar;10(2):227-36.

Sinha,R, Fisch G, Teague B, Tamborlane WJ, Banyas B, Allen K, Savoye M, Rieger V, Taksali S, Barbetta G, Sherwin R.S., Caprio S.  Prevalence of Impaired Glucose Tolerance among Children and Adolescents with Marked Obesity.  N Engl J Med. 2002 Mar; 346(11); 802-810  

Cardiovascular

Gidding SS, Bao W, Srinivasan SR, Berenson GS. Effects of secular trends in obesity on coronary risk factors in children: the Bogalusa Heart Study. J Pediatr. 1995 Dec;127(6):868-74.  

Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics. 1999 Jun;103(6 Pt 1):1175-82.

Freedman DS, Khan LK, Dietz WH, Srinivasan SR, Berenson GS. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa Heart Study. Pediatrics. 2001 Sep;108(3):712-8.

Watts K, Beye P, Siafarikas A, O'Driscoll G, Jones TW, Davis EA, Green DJ. Effects of exercise training on vascular function in obese children. J Pediatr. 2004 May;144(5):620-5.

Woo KS, Chook P, Yu CW, Sung RY, Qiao M, Leung SS, Lam CW, Metreweli C, Celermajer DS. Effects of diet and exercise on obesity-related vascular dysfunction in children. Circulation. 2004 Apr 27;109(16):1981-6. Epub 2004 Apr 5.

Franks PW,  Hanson R L, Knowler W C, Sievers ML,  Bennett PH,  Looker HC. Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med. 2010 Feb; 362(6):485-493

Metabolic Syndrome

Chia DJ, Boston BA. Childhood obesity and the metabolic syndrome. Adv Pediatr. 2006;53:23-53. Review.

Retnakaran R, Zinman B, Connelly PW, Harris SB, Hanley AJ. Nontraditional cardiovascular risk factors in pediatric metabolic syndrome. J Pediatr. 2006 Feb;148(2):176-82.

Wells GD, Noseworthy MD, Hamilton J, Tarnopolski M, Tein I. Skeletal muscle metabolic dysfunction in obesity and metabolic syndrome. Can J Neurol Sci. 2008 Mar;35(1):31-40.  

Zimmet P, Alberti KG, Kaufman F, Tajima N, Silink M, Arslanian S, Wong G, Bennett P, Shaw J, Caprio S; IDF Consensus Group. The metabolic syndrome in children and adolescents - an IDF consensus report. Pediatr Diabetes. 2007 Oct;8(5):299-306.

Weiss R, Dziura J, Burgert TS, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med. 2004 June;350(23):2362-2374.  

Psychology

Burrows A, Cooper M. Possible risk factors in the development of eating disorders in overweight pre-adolescent girls. Int J Obes Relat Metab Disord. 2002 Sep;26(9):1268-73.

Goldschmidt AB, Aspen VP, Sinton MM, Tanofsky-Kraff M, Wilfley DE. Disordered eating attitudes and behaviors in overweight youth. Obesity (Silver Spring). 2008 Feb;16(2):257-64.  

van Wijnen LG, Wendel-Vos GC, Wammes BM, Bemelmans WJ.The impact of school-based prevention of overweight on psychosocial well-being of children. Obes Rev. 2009 Feb 19. [Epub ahead of print].  

Interventions

General Interventions

Austin SB, Field AE, Wiecha J, Peterson KE, Gortmaker SL. The impact of a school-based obesity prevention trial on disordered weight-control behaviors in early adolescent girls. Arch Pediatr Adolesc Med. 2005 Mar;159(3):225-30.

Kirk S, Scott BJ, Daniels SR. Pediatric obesity epidemic: treatment options. J Am Diet Assoc. 2005 May;105(5 Suppl 1):S44-51. Review.

Oude Luttikhuis H, Baur L, Jansen H, Shrewsbury VA, O'Malley C, Stolk RP, Summerbell CD. Interventions for treating obesity in children. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001872. Review.

McDonald SD. Management and prevention of obesity in adults and children. CMAJ. 2007 Apr 10;176(8):1109-10.  

Miller JL, Silverstein JH. Management approaches for pediatric obesity. Nat Clin Pract Endocrinol Metab. 2007 Dec;3(12):810-8.

Singh AS, Chin A Paw MJ, Brug J, van Mechelen W. Dutch obesity intervention in teenagers: effectiveness of a school-based program on body composition and behavior. Arch Pediatr Adolesc Med. 2009 Apr;163(4):309-17.

Story M, Nanney MS, Schwartz MB. Schools and obesity prevention: creating school environments and policies to promote healthy eating and physical activity. Milbank Q. 2009 Mar;87(1):71-100.

Physcial Activity Interventions

Harris KC, Kuramoto LK, Schulzer M, Retallack JE. Effect of school-based physical activity interventions on body mass index in children: a meta-analysis. CMAJ. 2009 Mar 31;180(7):719-26.

Nutritional Interventions

Lee K, Lee J, Bae WK, Choi JK, Kim HJ, Cho B. Efficacy of low-calorie, partial meal replacement diet plans on weight and abdominal fat in obese subjects with metabolic syndrome: a double-blind, randomised controlled trial of two diet plans - one high in protein and one nutritionally balanced. Int J Clin Pract. 2009 Feb;63(2):195-201.

Philippou E, Neary NM, Chaudhri O, Brynes AE, Dornhorst A, Leeds AR, Hickson M, Frost GS. The effect of dietary glycemic index on weight maintenance in overweight subjects: a pilot study. Obesity (Silver Spring). 2009 Feb;17(2):396-401.

Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, McManus K, Champagne CM, Bishop LM, Laranjo N, Leboff MS, Rood JC, de Jonge L, Greenway FL, Loria CM, Obarzanek E, Williamson DA. Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med. 2009 Feb 26;360(9):859-73.

Surgical Interventions

Buchwald H, Estok R, Fahrbach K, Banel D, Jensen MD, Pories WJ, Bantle JP, Sledge I. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med. 2009 Mar;122(3):248-256.e5. Review.