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Developmental & Stem Cell Biology

Rosenblum Lab

Welcome to the Laboratory of Norman D. Rosenblum!

Research in my lab focuses on mammalian renal development. Kidney tissue malformation, termed renal dysplasia, accounts for approximately 20 per cent of cases of childhood renal failure. Yet, the molecular mechanisms that control kidney malformation are largely undefined. Our particular interest is renal branching morphogenesis, defined as growth and branching of the ureteric bud and its daughter collecting ducts during embryonic renal development. Branching morphogenesis is controlled by embryonic tissue interactions, mediated by secreted growth factors. We are studying cellular and molecular mechanisms that control the effects of members of the bone morphogenetic protein (BMP) family of growth factors on tubular growth and branching in in vitro and in vivo models of kidney development.

This website features the molecules that are the current focus of our work and some of the people who work in the Rosenblum Lab.

For more information about our research, please click on the Research link in the left sub-menu.