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Rotin Lab

Related publications

Biological functions of the receptor tyrosine phosphatase PTPsigma

  • Murchie R, Guo CH, Persaud A, Muise A, ROTIN D.  Protein tyrosine phosphatase σ targets apical junction complex proteins in the intestine and regulates epithelial permeability.  Proc. Natl. Acad. Sci. USA (2014) 111: 693-8.
  • Muise A, Rotin D. Apical junction complex proteins and ulcerative colitis: a focus on the PTPRS gene. Expert Rev Mol Diagn. (2008) 8:465-77
  • Kirkham DL, Pacey LK, Axford MM, Siu R, Rotin D, Doering LC.Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture. BMC Neurosci. (2006) 7:5
  • Muise AM, Walters T, Wine E, Griffiths AM, Turner D, Duerr RH, Regueiro MD, Ngan BY, Xu W, Sherman PM, Silverberg MS, ROTIN D. Protein-tyrosine phosphatase sigma is associated with ulcerative colitis. Curr. Biol. (2007)17:1212-1218
  • Siu R, Fladd C, ROTIN D. N-cadherin is an in vivo substrate for protein tyrosine phosphatase sigma (PTPsigma) and participates in PTPsigma-mediated inhibition of axon growth. Mol. Cell. Biol. ( 2007) 27:208-219
  • McLean J, Batt J, Doering L, ROTIN D, Bain JR. Enhanced rate of regeneration and directional errors following sciatic nerve injury in receptor protein tyrosine phosphatase sigma knockout mice. J. Neurosci. 22:5481-5491, 2002.
  • Batt J, Asa S, Fladd C, ROTIN D. Pituitary, pancreatic and gut neuroendocrine defects in PTPsigma deficient mice. Mol. Endocrinol., 16:155-169, 2002.
  • Wallace MJ, Batt J, Fladd C, Henderson JT, Skarnes W, ROTIN D. Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPs Nature Genet.,21:334-338, 1999.
  • Wallace M, Fladd C, Batt J, ROTIN D. The second catalytic domain of the tyrosine phosphatase PTPd binds to and inhibits the first catalytic domain of PTPs Mol.Cell. Biol.,18:2608-2616, 1998.