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Rotin Lab

PTP sigma

Biological functions of the receptor tyrosine phosphatase PTPsigma

PTPsigma is a LAR family member composed of a cell adhesion-like ectodomain, single transmemebrane domain and 2 tandem intracellular catalytic domains. We had previously knocked out the gene for PTPsigma in mice, which resulted in neuroendocrine, neuronal and intestinal defects. We recently identified the cadherin proteins as in vivo substrates for PTPsigma. Using the knockout mice as well as DNA samples from patients, we demonstrated that PTPsigma is associated with ulcerative colitis. We are currently studying the role of PTPsigma in intestinal development, as well as in neuronal stem cell differentiation and axon guidance.

Schematic representation of PTP sigma:

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