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Rovet Lab

Giuseppe Mirabella

My research focuses on the development of vision, and how disruptions in visual development affect later visual and cognitive processing. The primary visual pathway undergoes its most significant development during gestation and the first postnatal year, and a normal visual system is required for optimal development of other cognitive brain areas. Thus, disease or trauma to the brain during the this early period may produce lasting functional deficits. I use behavioural, electrophysiological and imaging techniques to assess these functions in infants and adults.

My goal is to characterize functional deficits in affected populations, including using visual tests to determine disease severity and to identify which factors place children at greatest future risk. Among the clinical groups I have tested are infants with thyroid hormone insufficiencies, infants and children with infantile spasms, premature infants, and children with optic pathway gliomas.

Refereed Articles

Mirabella, G., Morong, S., Buncic, J.R., Snead, O.C., Logan, W.J., Weiss, S.K. Westall, C.A. (2007). Contrast sensitivity is reduced in children with infantile spasms. Investigative Ophthalmology and Vision Science, 48, 3610-3615.

Chang, B., Mirabella, G., Yagev, R., Banh, M., Westall, C.A., Mezer, E., Buncic, R.J. (2007). Non-invasive screening and diagnosis of optic pathway gliomas using sweep visually evoked potentials. Investigative Ophthalmology and Vision Science, 48, 2895-2902.

Mirabella, G., Kjaer, P., Norcia, A.M., Good, W.V., and Madan, A. (2006). Visual development in very low birth weight infants. Pediatric Research, 60, 435-439.

Hammoudi, D., Lee S., Perron A., Mirabella G., Buncic R., Logan W.J., Snead O.C., Westall C.A. (2005). Reduced vision function associated with infantile spasms in children on vigabatrin therapy. Investigative Ophthalmology and Vision Science, 46, 514-520.

Mirabella, G., Westall, C., Asztalos, E., Koren, G., & Rovet, J.F. (2005). The development of contrast sensitivity in infants with prenatal and neonatal thyroid hormone insufficiencies. Pediatric Research 57(6), 902-7.

Mirabella, G., Feig, D., Astzalos, E., Perlman, K., & Rovet, J.F. (2000). The effect of abnormal intrauterine thyroid hormone economies on infant cognitive abilities. Journal of Pediatric Endocrinology & Metabolism, 13, 191-194.