SIDNET
The SIDNET facility provides the academic community access to a wide variety of automation platforms, high-throughput and high-content technologies for assay development and screening projects which otherwise may be unavailable through traditional grant support. A variety of in vivo cell based screening approaches to identify the role of specific genes and gene families in cell signalling pathways and networks are available utilizing SIDNET’s extensive clone archive of expression-ready cDNA and shRNA.
Integration of liquid-handling, cell culture and detection technologies facilitates an uninterrupted workflow resulting in increased quantity and quality of data. The CataLyst Express articulated arm, positioned to retrieve and place plates from a plate hotel and delidding station, is integrated with a bar code reader, BioTek plate washer, Thermo Kendro Cytomat cell culture incubator, Perkin Elmer PlateStak storage, Perkin Elmer Envision multimode plate reader and the Perkin Elmer Evolution 96/384 well liquid handling system. These as well as additional robotics and detection instruments are also available offline for use in assay development and validation. High-content screening with automated robotic liquid handling and microscopy of live cells using the Cellomics KSR is capable of resolving spatially and temporally separated fluorescent labels to quantitatively measure multiple features simultaneously to determine the effects of gene overexpression, knock-down or small molecules on cellular phenotypes.
Additionally a variety of in vitro screening approaches are also available using purified proteins in multi-well plates and custom printed or commercially available protein arrays.
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