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Sharpe Lab


Sharpe S, Yau W-M, Tycko R. (2006) Structure and dynamics of the HIV-1 Vpu transmembrane domain revealed by solid state NMR with magic-angle spinning. Biochemistry 45: 918-933. *

* Selected as a Biochemistry "Hot Article"

Sharpe S, Yau W-M, Tycko R. (2005) Expression and purification of a peptide from the Alzheimer's -amyloid protein for solid-state NMR. Protein Express. Purif. 42: 200-210.

Goodyear DJ, Sharpe S, Grant CWM, Morrow MR. (2005) Molecular dynamics simulation of transmembrane polypeptide orientational fluctuations. Biophysical Journal 88:105-117.

Sharpe S, Kessler N, Anglister JA, Yau W-M, Tycko R. (2004) Solid-state NMR yields structural constraints on the V3 loop from HIV-1 gp120 bound to the 447-52D antibody Fv fragment. J. Am. Chem. Soc. 126: 4979-4990.

Sharpe S, Barber KR, Grant CWM, Goodyear D, Morrow MR. (2002) Organization of model helical peptides in lipid bilayers: insight into the behaviour of single-span protein transmembrane domains. Biophysical Journal 83: 345-358.

Sharpe S, Barber KR, Grant CWM. (2002) Interaction between ErbB-1 and ErbB-2 transmembrane domains in bilayer membranes. FEBS Letters 519: 103-107.

Sharpe S, Barber KR, Grant CWM. (2002) Evidence of a tendency to self-association of the transmembrane domain of ErbB-2 in fluid phospholipid bilayers. Biochemistry 41: 2341-2352.

Sharpe S, Grant CWM, Barber KR, Giusti J, Morrow MR. (2001) Structural implications of a Val-Glu mutation in transmembrane peptides from the EGF receptor. Biophysical Journal 81: 3231 3239.

Sharpe S, Grant CWM. (2000) A transmembrane peptide from the human EGF receptor: Behaviour of the cytoplasmic juxtamembrane domain in lipid bilayers. Biochim. Biophys. Acta. (Biomembranes) 1468: 262-272.

Sharpe S, Barber KR, Grant CWM. (2000) Val659Glu mutation within the transmembrane domain of ErbB-2: effects measured by 2H NMR in fluid phospholipid bilayers. Biochemistry 39: 6572-6580.

Jones DH, Ball EH, Sharpe S, Barber KR, Grant CWM. (2000) Expression and membrane assembly of a transmembrane region from Neu: correlation between wideline 2H NMR and SDS-PAGE. Biochemistry 39:1870-1878.