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Bagli Lab
Bagli Lab

Dr. Armando Lorenzo

Research fellow (2005-2006)

Armando came to us with an extensive research background, both clinically and experimentally. He did his undergraduate and medical training in Panama, and his clinical residencies and fellowships in the U.S. The focus of his work in Dr. Bagli’s lab was how the muscarinic receptors responsible for bladder contraction affects ERK activation and ERK-mediated proliferation of bladder smooth muscle cells (BSMC). BSMC proliferation can be inhibited by M2/M3 receptors, but the mechanism of this action was hitherto unknown.

Present activities:
Armando is now a staff urologist with SickKids, involved in clinical epidemiology in the Division of Urology. staff profile »»

Publications while in our lab:
Sabha, N., K. Aitken, A.J. Lorenzo, M. Szybowska, A. Jairath, and D.J. Bagli, Matrix metalloproteinase-7 and epidermal growth factor receptor mediate hypoxia-induced extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase activation and subsequent proliferation in bladder smooth muscle cells. In Vitro Cell Dev Biol Anim, 2006. 42(5): p. 124-33.

Aitken, K.J., G. Block, A. Lorenzo, D. Herz, N. Sabha, O. Dessouki, F. Fung, M. Szybowska, L. Craig, and D.J. Bagli, Mechanotransduction of extracellular signal-regulated kinases 1 and 2 mitogen-activated protein kinase activity in smooth muscle is dependent on the extracellular matrix and regulated by matrix metalloproteinases. Am J Pathol, 2006. 169(2): p. 459-70.

Halachmi, S., K.J. Aitken, M. Szybowska, N. Sabha, S. Dessouki, A. Lorenzo, D. Tse, and D.J. Bagli, Role of signal transducer and activator of transcription 3 (STAT3) in stretch injury to bladder smooth muscle cells. Cell Tissue Res, 2006. 326(1): p. 149-58.

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