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Bagli Lab
Bagli Lab

Research activities

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The urinary bladder is the organ that stores and empties urine. From a scientific point of view, bladder research has generally focused on cancer or incontinence associated with aging. However, a great deal remains to be learned about bladder dysfunction and disease in children. Children's bladder disorders can be quite far ranging. Our lab is focusing on three major areas of research:

(1) Bladder outlet obstruction. We are studying the bladder disease that arises when the bladder is unable or unwilling to store or empty properly. This leads to tissue changes in the bladder wall, which resemble overgrowth and scarring. We are attempting to understand the molecular components most responsible for these changes. read more ...

(2) Epigenetics of urinary tract infection (UTI). UTI is the second most common type of infection in children. While it is treatable by antibiotics, if it happens at the same time as reflux, it needs to be diagnosed or treated rapidly to prevent kidney infections, upstream of the bladder. We are studying epigenetic alterations that might occur during infection to understand how the bacteria can alter the host response to infection. read more ...

(3) Stem cells in the bladder: Regenerative therapies in the past have focused on using stem cells from the bone marrow in order to repair or regenerate new bladders. We are focusing on using skin derived-precursor stem cells (SKPs) to integrate into the bladder and better understand the process of muscle differentiation in developing or injured bladders. read more ...