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Open Studies

In partnership with other site investigators in Toronto and across Canada, our program has a number of research studies currently underway. Our studies include:

Canadian Pediatric Demyelinating Disease Study

Currently in Phase 3, this longitudinal research study is examining clinical-demographic, epidemiological, pathobiological, as well as neuro-imaging features and outcomes of acute demyelination in Canadian children. We would like to learn more about why demyelination occurs. To do this, we need to learn more about Canadian children with demyelination as well as those without a history of demyelination or multiple sclerosis (MS). Patients and healthy research volunteers participate by completing various components: MRI brain scan, neurocognitive assessment, various clinical questionnaires and by providing a blood sample, stool sample and mouth swab. Patients are invited to participate in the study at the time of their first demyelinating attack and are followed at 3, 6, 12, 24 and 36 months post their first demyelinating event.

The participation of healthy research volunteers is extremely important to provide a means of comparison. Healthy research volunteers without a history of demyelination or MS are asked to complete one study visit.

Patients and healthy research volunteers can visit Research Components for more detailed information.

Closed Studies

New Emerging Team Study (NET)

This study is looking at whether children and adults with autoimmune diseases such as, multiple sclerosis, inflammatory bowel disease, and diabetes share common abnormalities in immune function. Patients and healthy research volunteers participate by providing a blood sample and completing a clinical questionnaire.

Cerebral Venous Hemodynamics in paediatric multiple sclerosis

Abnormal venous flow, also called cerebrospinal venous insufficiency (CCSVI), has recently been a major focus of MS research. Some studies have reported that one possible cause of MS might be impairment of normal blood flow in the brain and spine. According to the new theory, partially or completely blocked veins lead to poor venous drainage, causing increased pressure and injury in the veins. Injured veins permit the entry of immune cells into the brain and spine, causing inflammation and damaging myelin, the protective covering in brain cells or neurons.

Our team has been awarded one of seven grants in North America to study blood flow patterns in the brains of children and teens with MS as well as healthy children and teens. Patients and healthy research participants take part by completing an MRI and Doppler ultrasound. A blood sample is also collected.

 For more information on MRI and Doppler ultrasound please visit Diagnostic Imaging.