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Translational Medicine

Coles Lab

Principal Investigator

John Coles, MD

Post-docs, Fellows
Huanzhang Lu

Research Technologist
Xiajing Dai

Student
Caroline Holtby

Research Activities

Our group is concerned with the mechanisms through which common clinical diseases affect survival of cardiac muscle cells. Many injurious stresses to the heart activate signaling pathways within the cardiomyocyte leading to cell death manifest as various forms of heart failure. Our studies are designed to further understand the nature of these signaling events by exploiting the several complementary molecular technologies, including DNA microarray and proteomics. The objective is to develop conceptually new and disease-specific therapeutic targets.

Publications

West LJ, Karamlou T, Dipchand AI, Pollock-BarZiv SM, Coles JG, McCrindle BW: Impact on outcomes after listing and after transplantation of strategy to accept ABO blood group incompatible donor hearts for neonates and infants. Journal of Thoracic and Cardiovascular Surgery 2006: 131(2): pp 455-461.

Yun T-J, Al-Radi OO, Adatia I, Caldarone CA, Coles JG, Williams WG, Smallhorn J, Van Arsdell GS: Contemporary management of right atrial isomerism: effect of evolving therapeutic strategies. Journal of Thoracic and Cardiovascular Surgery 2006: 131(5): pp 1108-1113.

Zuker RM, Redett R, Alman B, Coles JG, Timoney N, Ein SH: First successful lower-extremity transplantation: technique and functional result. Journal of Reconstructive Microsurgery 2006: 22(4): pp 239-244.

Alsoufi B, Karamlou T, Bradley T, Williams WG, Van Arsdell GS, Coles JG, Smallhorn J, Nii M, Guerra V, Caldarone CA: Short and midterm results of aortic valve cusp extension in the treatment of children with congenital aortic valve disease. Annals of Thoracic Surgery 2006: 82(4): pp 1292-1299.

Alsoufi B, Karamlou T, Asaki M, Badiwala MV, Ching CC, Dipchand A, McCrindle BW, Coles JG, Caldarone CA, Williams WG, Van Arsdell GS: Surgical repair of multiple muscular ventricular septal defects: the role of re-endocardialization strategy. Journal of Thoracic and Cardiovascular Surgery 2006: 132 (5): pp 1072-1080.

Lu H, Fedak P, Dai X, Du C, Zhou Y, Henkelman M, Mongroo PS, Lau A, Yamabi H, Hinek A, Husain M, Hannigan G, Coles GJ: Integrin linked kinase (ILK) expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice. Circulation 2006: 114(21): pp 2271-2279.

Roman KS, Nii M, Macgowan CK, Barrea C, Coles JG, Smallhorn JF: The impact of patch augmentation of left atrioventricular valve dynamics in patients with atrioventricular septal defects. Early and midterm follow-up. Journal of Thoracic and Cardiovascular Surgery 2006: 19 (11): pp 1382-1392.

Yamabi H, Lu H, Dai X, Lu Y, Hannigan G, Coles JG: Overexpression of integrin-linked kinase induces cardiac stem cell expansion. Journal of Thoracic and Cardiovascular Surgery 2006: 132 (6): pp 1272-1279.

Division of Pediatric Surgery, Otolaryngology, Anaesthesia, Cardiac Surgery, Critical Care, Perfusion: Recent challenges in the management of congenital tracheal stenosis: an individualized approach. Journal of Pediatric Surgery 2005: 40: pp 774-780.

DeOliveira NC, Sittiwangkul R, McCrindle BW,Dipchand A, Yun T-J, Coles JG, Caldarone C, Williams WG, VanArsdell GS: Biventricular repair in children with atrioventricular septal defects and a small right ventricle: Anatomic and surgical considerations. Journal of Thoracic and Cardiovascular Surgery 2005: 130: pp 250-257.

Roman KS, Kellenberger CJ, Macgowan CK, Coles JG, Redington AN, Benson LN, Yoo S-J: How is pulmonary arterial blood flow affected by pulmonary venous obstruction in children? A phase-contrast magnetic resonance study. Pediatric Radiology 2005: 35: pp 580-586.

Chan EH, Russell JL, Williams WG, VanArsdell GS, Coles JG, McCrindle BW: Postoperative chylothorax after cardiothoracic surgery in children. Annals of Thoracic Surgery 2005: 80(5): pp 1864-1870.

Guerra VC, Coles J, Smallhorn JF: Aneurysm of right atrium diagnosed by 3-dimensional real-time echocardiogram. Journal of American Soc Echocardiography 2005: 18(11): pp 1221.

Karamlou T, Jang K, Williams WG, Caldarone CA, Van Arsdell G, Coles JG, McCrindle: Outcomes and associated risk factors for aortic valve replacement in 160 children a competing-risks analysis. Circulation 2005: 112: pp 3462-3469.

Kojori F, Chen R, Caldarone CA, Merklinger SL, Azakie A, Williams WG, VanArsdell GS, Coles J, McCrindle BW: Outcomes of mitral valve replacement in children: a competing-risks analysis. Journal of Thoracic and Cardiovascular Surgery 2005: 128(5): pp 703-709.

Konstantinov IE, Arab S, Kharbanda R, Li J, Coles JG, Boscarino C, Alessandro M, Cukerman E, Dawood F, Cheung MMH, Shimizu M, Liu PP, Redington AN: The remote ischemic preconditioning stimulus modifies gene expression in mouse myocardium. Journal of Thoracic and Cardiovascular Surgery 2005: 130: pp 1326-1332.

Books/Chapters in Books

  1. Konstantinov IE, Yun T-J, Caldarone CA, Coles JG: Supramitral obstructoin of left ventricular inflow tract by supramitral ring. In: Operative Techniques in Thoracic and Cardiovascular Surgery: A Comparative Atlas (James L. Cox, ed). W.B. Saunders, New York 2004: pp 247-215.
  2. Konstantinov IE, Coles JG: The role of intraoperative device closure in the management of muscular ventricular septal defects. In: Pediatric Cardiac Surgery Annual 2003 (Constantine Mavroudis, ed). Elsevier Science Inc., New York 2003: pp 84-89.
  3. Freedom RM, Adatia I,Coles JG, Konstantinov I: Congenital stenosis of the individual pulmonary veins. In: The Natural And Modified History of Congenital Heart Disease (Robert M. Freedom, Shi-Joon Yoo, Haverj Mikailian, William G. Wiliams, eds). Blackwell, New York 2003: pp 302-305.
  4. Freedom RM, Yoo S-J, Coles JG: Atrioventricular septal defect. In: The Natural And Modified History of Congenital Heart Disease (Robert M. Freedom, Shi-Joon Yoo, Haverj Mikailian, William G. Wiliams, eds). Blackwell, New York 2003: pp 44-55.
  5. Freedom RM, Yoo S-J, Coles JG: Congenital abnormalities of the mitral valve. In: The Natural And Modified History of Congenital Heart Disease (Robert M. Freedom, Shi-Joon Yoo, Haverj Mikailian, William G. Wiliams, eds). Blackwell, New York 2003: pp 99-106.
  6. Freedom RM, Yoo S-J, Coles JG, Konstantinov I: Total anomalous pulmonary venous connections. In: The Natural And Modified History of Congenital Heart Disease (Robert M. Freedom, Shi-Joon Yoo, Haverj Mikailian, William G. Wiliams, eds). Blackwell, New York 2003: pp 282-289.
  7. Freedom RM, Yoo S-J, Coles JG, Konstantinov I: Ventricular septal defect. In: The Natural And Modified History of Congenital Heart Disease (Robert M. Freedom, Shi-Joon Yoo, Haverj Mikailian, William G. Wiliams, eds). Blackwell, New York 2003: pp 16-30.
  8. Dellgren G, Coles JG: Pediatric heart transplantation: improving results in high-risk patients. In: Pediatric Cardiac Surgery Annual 2001 (Coles JG, Williams WG, eds). W. B. Saunders Company, Philadelphia 2001: pp 103-114.
  9. Poirier NC, Coles JG: Cardiac transplantation: surgical considerations. In: Pediatric Anesthesia: Principles & Practice (Burno Bissonnette, Bernard Dalens, eds). McGraw-Hill, USA 2001: pp 1291-1298.

Contact Information

Admin Assistant
Helen Trifunovski
e-mail: helen.trifunovski@sickkids.ca

Mailing Address
The Hospital for Sick Children
555 University Ave.
Room 1518C, Hill Wing
Toronto, ON M5G 1X8

Tel: (416) 813-6204
Fax: (416) 813-7984
e-mail: john.coles@sickkids.ca