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Translational Medicine

Henkelmen Lab

  • Principal Investigator

Mark Henkelman, PhD

Postdoctoral Fellows
Francois-Xavier Ble
Jacob Ellegood
Monica Hasegan
Jian Yang

Graduates
Johnathon Walls, PhD graduate
Xiao Lee Zeng, PhD graduate
Michael Wong, MSc graduate

Research Activities

With the completion of the human genome, a major outstanding question in biomedical research is the relationship between genes and normal development or disease. Over this century, much of this will be worked out using mouse models of human diseases, because the genes and their function in the mouse are very similar to the human.

When we look for human diseases in the human population, we make extensive use of medical imaging. Therefore, it makes sense to have available the same imaging capabilities as we investigate mice for models of human disease.

As director, my research is focused on building the Mouse Imaging Centre (MICe) with high field magnetic resonance imaging microscopy, ultrasound biomicroscopy, micro computed tomography, and optical techniques. With these imaging tools, the centre will screen randomly and targeted mutagenized mice to look for phenotypes that represent human diseases and will take established human disease models in mice and use imaging to follow the progression of disease and response to treatment over time. Preliminary results have shown that imaging has a major contribution to make to phenotyping genetic variants and to characterizing mouse disease models. Imaging is also critical for assessing mammalian development and environmental effects such as learning.

Publications

D.J. Tyler, M.D. Robson, R.M. Henkelman, I.R. Young, G.M. Bydder. Magnetic resonance Imaging with Ultrasound TE (UTE) PULSE Sequences: Technical Considerations. J. Magn. Reson. Imaging 25(2):279-289, 2007.

Zhou YQ, Bishay R, Feintuch A, Tao K, Golding F, Zhu W, West LJ, Henkelman RM. Morphological and functional evaluation of murine heterotopic cardiac grafts using ultrasound biomicroscopy. Ultrasound Med Biol. 2007 Jun;33(6):870-9. Epub 2007 Apr 16. PMID: 17434663

Nieman BJ, Bishop J, Dazai J, Bock NA, Lerch JP, Feintuch A, Chen XJ, Sled JG, Henkelman RM. MR technology for biological studies in mice. NMR Biomed. 2007 May;20(3):291-303. Review. PMID: 17451169

Williams R, Needles A, Cherin E, Zhou YQ, Henkelman RM, Adamson SL, Foster FS. Noninvasive ultrasonic measurement of regional and local pulse-wave velocity in mice. Ultrasound Med Biol. 2007 Sep;33(9):1368-75. Epub 2007 Jun 11. PMID: 17561330

Walls JR, Sled JG, Sharpe J, Henkelman RM.Resolution improvement in emission optical projection tomography. Phys Med Biol. 2007 May 21;52(10):2775-90. Epub 2007 Apr 27. PMID: 17473351

Spring S, Lerch JP, Henkelman RM. Sexual dimorphism revealed in the structure of the mouse brain using three-dimensional magnetic resonance imaging. Neuroimage. 2007 May 1;35(4):1424-33. Epub 2007 Mar 1. PMID: 17408971

Nieman BJ, Lerch JP, Bock NA, Chen XJ, Sled JG, Henkelman RM. Mouse behavioral mutants have neuroimaging abnormalities. Hum Brain Mapp. 2007 Jun;28(6):567-75. PMID: 17437292

K. Klüppel, K. Liu, C. Chan, T. Wight, N. Lifshitz, R.M. Henkelman, J.L. Wrana, A. Hinek. Critical role for C4ST-1 and chondroitin sulfation imbalance in the pathogenesis of Costello syndrome. Submitted to Nature Genetics (June 2005).

Contact Information

Admin Assistant
Lynda Cockroft
e-mail: cockroft@phenogenomics.ca

Mailing Address
Mouse Imaging Centre
The Hospital for Sick Children
The Centre for Phenogenomics
25 Orde St.
Toronto, ON M5T 3H7

Tel: (647) 837-5820
Fax: (647) 837-5832
e-mail: mhenkel@phenogenomics.ca

Website: Mouse Imaging Centre