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Translational Medicine

Redington Lab

Principal Investigator

Andrew N. Redington, MB, BS, MRCP (UK), MD, FRCP (UK)

Post-docs, Fellows
Wei Zhu
Jing Li
Jia Li

Research Activities

Present research concentrates on analysis of myocardial performance using the abnormalities imposed by congenital heart disease and its surgery as natural models of chronic 'heart failure'.

Current research interests are in two major areas: the non-invasive assessment of myocardial contractility using tissue Doppler techniques, and the use of a novel remote ischemic pre-conditioning protocol to protect the myocardium and other organs from the ischemic insult of cardiopulmonary bypass and ischemia re-perfusion injury.

Additional areas of interest include: right left heart interactions and their measurement using conductance catheter technologies, and the assessment of oxygen consumption and mechanisms of hibernation as they may apply to post-operative intensive care.

Future research will move towards development of non-invasive techniques for assessing myocardial performance and the use of innate mechanisms of protection (eg. ischemic pre-conditioning) during cardiac surgery.

Publications

Li J, Konstantinov IE, Cai S, Shimizu M, Redington AN: Systemic and myocardial oxygen transport responses to brain death in pigs. Transplantation Proceedings 2007: 133(2): pp 21-6.

Li J, Zhang G, McCrindle BW, Holtby H, Humpl T, Cai S, Caldarone CA, Redington AN, Van Arsdell GS: Profiles of hemodynamics and oxygen transport derived by using continuous measured oxygen consumption aftr the Norwood procedure. Journal of Thoracic and Cardiovascular Surgery 2007: 133(2): pp 441-8.

Grosse-Wortmann L, Al-Otay A, Woo Goo H, Macgowan CK, Coles JG, Benson LN, Redington AN, Yoo SJ: Anatomical and functional evaluation of pulmonary veins in children by magnetic resonance imaging. Journal of the American College of Cardiology 2007: 49(9): pp 993-1002.

Nielsen JM Kristiansen SB, Ringgaard S, Nielsen TT, Flyvbjerg A, Redington AN, Botker HE: Left ventricular volume measurement in mice by conductance catheter. Evaluation and optimization of calibration. American Journal of Physiology - Heart and Circulatory Physiology 2007: e-pub.

Shimizu M, Konstantinov IE, Kharbanda RK, Cheung MH, Redington AN: Effects of intermittent lower limb ischaemia on coronary blood flow and coronary resistence in pigs. Acta Physiologica 2007: 190(2): pp 103-9.

Chaturvedi RC, Redington AN: Pulmonary regurgitation in congenital heart disease. Heart 2007: 93(7): pp 880-9.

Redington AN: Pathophysiology of right ventricular failure. Seminars in Thoracic and Cardiovascular Surgery 2006: 2006: pp 3-10.

Cheung M, Kharbanda RK, Konstantinov I, Shimizu M, Frndova H, Li J, Holtby HM, Cox PN, Smallhorn JF, Van Arsdell GS, Redington AN: Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. Journal of the American College of Cardiology 2006: 47(11): pp 2277-82.

Stoica SC, Satchithananda DK, White PA, Sharples L, Parameshwar J, Redington AN, Large SR: Brain death leads to abnormal contractile properties of the human donor right ventricle. Journal of Thoracic and Cardiovascular Surgery 2006: 132(1): pp 116-23.

Kharbanda RK, Li J, Konstantinov I, Cheung M, White P, Frndova H, Stokoe J, Cox P, Vogel M, Van Arsdell G, Macallister R, Redington AN: Remote ischemic preconditioning protects against cardiopulmonary bypass induced tissue injury - a preclinical study. Heart 2006.

Redington AN: Determinants and assessment of pulmonary regurgitation in tetralogy of Fallot: practice and pitfalls. Cardiology Clinics 2006: 24(4): pp 631-9.

Li J, H, Zhang G, Holtby H, Humpl T, Caldarone CA, Van Arsdell GS, Redington AN: Adverse effects of dopamine on systemic hemodynamic status and oxygen transport in neonates after the Norwood procedure. Journal of the American College of Cardiology 2006: 48(9): pp 1859-64.

Nii M, Roman KS, KingdomJ, Redington AN, Jaeggi ET: Assessment of the evolution of normal fetal diastolic function during mid and late gestation by spectral Doppler tissue echocardiography. Journal of the American Society of Echocardiography 2006: 19(12): pp 1431-7.

Takahashi K, Guerra V, Roman KS Nii M, Redington AN, Smallhorn JF: Three-dimensional echocardiography improves the understanding of the mechanisms and site of left atrioventricular valve regurgitation in atrioventricular septal defect. Journal of the American Society of Echocardiography 2006: 19(12): pp 1502-10.

Schmidt MR, Smerup M, Konstantinov IE, Shimizu M, Li J, Cheung M, White PA, Kristiansen SB, Sorensen KE, Dzavik V, Redington AN, Kharbanda RK: Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction: first demonstration of remote ischemic preconditioning. American Journal of Physiology Hear and Circulation Physiology 2006.

Books/Chapters in Books

  1. Cheung M, Redington AR: Systolic and diastolic dysfunction. In: Heart Failure in Children and Young Adults: From Molecular Mechanisms to Medical and Surgical Strategies (Chang AC, Towbin JA, eds). Saunders Elsevier, Philadelphia 2006: pp 114-28.
  2. Vogel M and Redington AN: Assessment of contractile function by Doppler myocardial imaging: isovolumic versus ejection phase indices. In: Doppler Myocardial Imaging (Sutherland GR, Hatle L, Claus P, D'hooge J, Bijnens BH, eds). BSWK, Hasselt, Belgium 2006: pp 103-111.
  3. Redington AN: Balloon dilation and stenting in coarctation of the aorta. In: The Left Heart in Congenital Heart Disease (Redington AN, Brawn WB, Deanfield JE, Anderson RH, eds). GMM, London 2000.
  4. Redington AN: Cardiac disease, 2nd edition. In: An Illustrated Textbook of Paediatrics (Lissauer T, Clayton M, eds). Mosby, London 2000.
  5. Redington AN, Brawn WB, Deanfield JE, Anderson RH: The left heart in congenital heart disease. Greenwich Medical Media, London, England 2000.
  6. Redington AN, Penny DJ: Univentricular atrioventriuclar connection. In: Paediatric Cardiology, 2nd edition (Anderson RH, Baker E, Rigby ML, Shinebourne EA, Tynan M, eds). Churchill Livingstone Company Ltd., London 2000.
  7. Ho SY, Redington AN, Rigby ML, Anderson RH: Echocardiography in congenital heart disease. World Scientific Publishing, London, England 1999.
  8. Anderson RH, Ho SY, Redington AN: The normal heart. Imperial College Press, London 1998.
  9. Redington AN: Epilogue-what have we learnt? In: The Right Heart (Redington AN, Brawn WB, Deanfield JE, Anderson RH, eds). GMM, London 1998.
  10. Redington AN, Brawn WB, Deanfield JE, Anderson RH: The right heart. Greenwich Medical Media, London 1998.
  11. Redington AN: Stenting of pulmonary arteries and veins. In: Handbook of Cardiovascular Interventions (Bertrand, Serruys and Sigwart, eds). Churchill Livingstone Company Ltd., New York 1996.

Contact Information

Admin Assistant
Karen Hodgson
e-mail: karen.hodgson@sickkids.ca

Mailing Address
The Hospital for Sick Children
555 University Ave.
Atrium, Room 1725C
Toronto, ON M5G 1X8

Tel.: (416) 813-6135
Fax: (416) 813-7547
e-mail: andrew.redington@sickkids.ca