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Translational Medicine

Schwartz Lab

Principal Investigator

Steven Schwartz, MD, FRCPC

Research Activities

  • Effects of cardiopulmonary bypass on neonatal cardiac function;
  • Role of genetics in response to cardiac surgery and pharmacological cardiovascular support.

Publications

Graham Jr TP, Beekman III RH, Allen HD, Bricker JT, et al: ACC/AHA/AAP Recommendations for training in pediatric cardiology. Circ 112(16):2555-80, 2005.

Kulik T, Giglia TM, Kocsis KC, Mahoney LT, Schwartz SM, Wernovsky G, Wessel DL: ACC/AHA/AAP Recommendations for training in pediatric cardiology. Task Force 5: Requirements for pediatric cardiac critical care. JACC 46(7)1396-9, 2005.

Duffy JY, Schwartz SM, Lyons JM, Bell JH, Wagner CJ, Zingarelli B, Pearl JM: Calpain inhibition decreases endothelin-1 levels and pulmonary hypertension after cardiopulmonary bypass with deep hypothermic circulatory arrest. Crit Care Med 33(3):623-8, 2005.

Eghtesady P, Nelson DP, Schwartz SM, Wheeler D, Pearl JM, Cripe LH, Manning PB: Heparin-induced thrombocytopenia complicating support by the Berlin Heart. ASAIO J 51(6):820-5, 2005.

Dent CL, Spaeth JP, Jones BV, Schwartz SM, Glauser TA, Hallinan B, Pearl JM, Khoury PR, Kurth CD: Brain MRI abnormalities after the Norwood procedure using regional cerebral perfusion. J Thorac Cardiovasc Surg 130(6):1523-1530, 2005.

Cooper DS, Schwartz SM, Raake JL, Beam AR, Nelson DP: Supplemental inhaled gases alter tidal volume delivery and measurement. Ped Crit Care Med 6(2):150-153, 2005.

Pearl JM, Schwartz SM, Nelson DP, Wagner CJ, Lyons JM, Bauer SM, Duffy JY:: Preoperative glucocorticoids decreases pulmonary hypertension in piglets after cardiopulmonary bypass and circulatory arrest. Ann Thorac Surg 77(3):994-1000, 2004.

Duffy JY, Nelson DP, Schwartz SM, Wagner CJ, Bauer SM, Lyons JM, McNamara JL Pearl JM: Glucocorticoids reduce cardiac dysfunction after cardiopulmonary bypass and circulatory arrest in neonatal piglets. Pediatr Crit Care Med 5(1):28-34, 2004.

Nelson DP, Schwartz SM, Chang A.: Neonatal physiology of the functionally univentricular heart. Cardiol Young 14(Suppl 1):52-60, 2004.

Schroeder VA, Pearl JM, Schwartz SM, Shanley TP, Manning PB, Nelson DP: Combined steroid treatment for congenital heart surgery improves oxygen delivery and reduces post-bypass inflammatory mediator expression. Circ 107(22):2823-28, 2003.

Books/Chapters in Books

  1. Schwartz SM, Millar J.: Current issues and trends in the care of the postoperative pediatric cardiac surgery patient. In: Conway Jr., E.E. (ed) Current Concepts in Pediatric Critical Care, 2007, pp15-19.
  2. Berger III JT, Schwartz SM, Nelson DP.: Congenital heart disease. In: Slonim, A.D., Pollack, M.M. (eds): Pediatric Critical Care Medicine. Philadelphia: Lippincott Williams and Wilkens, 2006, pp623-632.
  3. Schwartz SM.: Cardiac surgery and postoperative management. In: Conway Jr., E.E., Relvas, M.C. (eds): Pediatric Multiprofessional Critical Care Review (USA). 2006, pp129-144.
  4. Schwartz SM.: Oxygen delivery and support of the failing heart. In: Conway Jr., E.E., Relvas, M.C. (eds): Pediatric Multiprofessional Critical Care Review (USA). 2006, pp99-108.
  5. Schwartz SM,: Cardiomyocyte function. In: Slonim, A.D., Pollack, M.M. (eds): Pediatric Critical Care Medicine. Philadelphia: Lippincott Williams and Wilkens, 2006, pp197-204.
  6. Schwartz SM.: Cellular mechanisms. In: Wernovsky, G., Shaddy, R.E. (eds): Heart Failure in Children: From the Fetus Through Adult Congenital Heart Disease. New York, NY, Marcel Dekker, Inc., Publishing Co, 2005, pp65-104.

Contact Information

Admin Assistant
Donna Cuscuna
e-mail: donna.cuscuna@sickkids.ca

Mailing Address
The Hospital for Sick Children
555 University Ave.
Atrium, Room 2830A
Toronto, ON M5G 1X8

Tel.: (416) 813-6186
Fax: (416) 813-7299
e-mail: steven.schwartz@sickkids.ca