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Translational Medicine

Silverman Lab

Principal Investigator

Earl Silverman, MD

Research Technologist
Lawrence Ng

PhD Student
Pascal Tyrell

Research Activities

My research program is focused on cardiovascular outcome in paediatric autoimmune disease.

Publications

Aviv RI, Benseler SM, DeVeber G, Silverman ED, Tyrrell PN, Tsang LM, Armstrong D: Angiography of primary CNS vasculitis of childhood (cPACNS): conventional angiography (CA) versus magnetic resonance angiography (MRA) at presentation. American Journal of Neuroradiology 2007: 28: pp 9-15.

Levine D, Akikusa J, Manson D, Silverman E, Schneider R: Chest CT findings in pediatric Wegener's granulomatosis. Pediatric Rheumatology 2007: 37:1: pp 57-62.

Sarkissian T, Beyenne J, Feldman B, McCrindle B, Silverman ED: Longitudinal examination of lipid profiles in pediatric systemic lupus erythematosus. Arthritis and Rheumatism 2007: 56:2: pp 631-638.

Saurenmann RK, Levin AV, Feldman BM, Rose JB, Laxer RM, Schneider R, Silverman ED: Prevalence, risk factors, and outcome of uveitis in juvenile idiopathic arthritis. Arthritis and Rheumatism 2007: 56:2: pp 647-657.

Silverman ED: Pediatric systemic lupus erythematosus. Future Medicine/Future Rheumatology 2007: 2:1: pp 23-50.

Aviv RI, Benseler SM, Silverman ED, Tyrrell PN, Deveber G, Tsang LM, Armstrong D: MR imaging and angiography of primary CNS vasculitis of childhood. American Journal of Neuroradiology 2006: 27:1: pp 192-199.

Silverman ED, Strand V: Leflunomide in juvenile idiopathic arthritis. Future Medicine/Future Rheumatology 2006: 1:6: pp 673-682.

Spence D, Hornberger LK, Hamilton RM, Silverman ED: Increased risk of complete congenital heart block in infants born to women with hypothyroidism and anti-Ro and/or anti-La antibodies. Journal of Rheumatology 2006: 33:1: pp 167-170.

Lang BA, Yeung RSM, Oen KG, Malleson PN, Huber AM, Riley M, Ebbeson R, Ramsey SE, Laxer RM, Silverman ED, McCrindle BW, Ratnapalan S, Feldman BM: Corticosteroid treatment of refractory Kawasaki disease. Journal of Rheumatology 2006: 33:4: pp 803-809.

Benseler SM, Silverman E, Aviv RI, Schneider R, Armstrong D, Tyrrell PN, de Veber G: Primary central nervous system vasculitis in children. Arthritis and Rheumatism 2006: 54:4: pp 1291-1297.

Chagnon P, Schneider R, Hebert J, Fortin PR, Provost S, Belisle C, Gingras M, Bolduc V, Perreault C, Silverman E, Busque L: Identification and characterization of an Xp22.33;Yp11.2 translocation causing a triplication of several genes of the pseudoautosomal region 1 in an XX male patient with severe systemic lupus erythematosus. Arthritis and Rheumatism 2006: 54:4: pp 1270-1278.

Sarkissian T, Beyene J, Feldman B, Adeli K, Silverman E: The complex nature of the interaction between disease activity and therapy on the lipid profile in patients with Pediatric systemic lupus erythematosus. Arthritis and Rheumatism 2006: 54:4: pp 1283-1290.

Avcin T, Schneider R, Tse S, Silverman ED: Macrophage activation syndrome as the presenting manifestation of rheumatic diseases in childhood. Journal of Pediatrics 2006: 148:5: pp 683-6.

Saurenmann RK, Levin AV, Rose JB, Parker S, Rabinovitch T, Tyrrell PN, Feldman BM, Laxer RM, Schneider R, Silverman, ED: Tumour necrosis factor alpha inhibitors in the treatment of childhood uveitis. Rheumatology (Oxford) 2006: 45:8: pp 982-9.

Saurenmann T, Schneider R, Silverman ED, Laxer RM, Levin AV: Risk of new-onset uveitis in patients with juvenile idiopathic arthritis treated with anti-TNF agents. Journal of Pediatrics 2006: 149: pp 833-6.

Books/Chapters in Books

  1. Benseler SM, Silverman ED: Systemic lupus erythematosis. In: Pediatric Clinics of North America. 52:2 2005: pp 443-467.
  2. Silverman ED: Neonatal lupus erythematosus. In: Textbook of Pediatric Rheumatology (Cassidy J, Petty R, eds). W.B. Saunders, Philadelphia, PA 2005: pp 450-464.
  3. Silverman ED, Hebert D: Pediatric systemic lupus erythematosus. In: Oxford Textbook of Rheumatology. 3rd edition, section 6, item 6.6.3 (Maddison PJ, Isenberg DA, Woo P, Glass DN, eds). Oxford University Press, London, UK 2004.
  4. Silverman ED: Mixed connective tissue disease. In: Rudolph's Pediatrics, 21st Edition (Rudolph CD, Rudolph AM, Eds., Hostetter MK, Lister G, Siegel NJ, Co-Eds., eds). McGraw-Hill Medical Publishing Division, New York 2003: pp 851-852.
  5. Silverman ED: Pediatric systemic lupus erythematosus. In: Rudolph's Pediatrics, 21st Edition (Rudolph CD, Rudolph AM, Eds., Hostetter MK, Lister G, Siegel NJ, Co-Eds., eds). McGraw-Hill Medical Publishing Division, New York 2003: pp 847-851.
  6. Silverman ED: Sjogren's syndrome. In: Rudolph's Pediatrics, 21st Edition (Rudolph CD, Rudolph AM, Eds., Hostetter MK, Lister G, Siegel NJ, Co-Eds., eds). McGraw-Hill Medical Publishing Division, New York 2003: pp 852-853.
  7. Silverman ED: Neonatal lupus erythematosus. In: Textbook of Pediatric Rheumatology (Cassidy J, Petty R, eds). W.B. Saunders, Philadelphia, PA 2001: pp 450-464.
  8. Silverman ED, Eddy A: Pediatric systemic lupus erythematosus. In: Oxford Textbook of Rheumatology. 2nd edition. Volume 2 (Maddison PJ, Isenberg DA, Woo P, Glass DN, eds). Oxford University Press, London, UK 1998: pp 1180-1201.
  9. Silverman ED, Laxer RM: Neonatal lupus erythematosus. In: Rheumatic Disease Clinics of North America. Volume 23 1997: pp 599-618.
  10. Laxer RM, Silverman ED: The pharmacological management of juvenile chronic arthritis. In: Balliere's Clinical Pediatrics: Arthritis in Children and Adolescence (Southwood TR, Malleson PN, eds). 1994: pp 3825-3873.
  11. Lang BA, Silverman ED: A clinical overview of systemic lupus erythematosus. In: Pediatrics in Review. Volume 14 American Academy of Pediatrics, 1993: pp 194-201.
  12. Silverman ED, Eddy A: Pediatric systemic lupus erythematosus. In: Oxford Textbook of Rheumatology. Volume 2 (Maddison, Isenberg, Woo, Glass, eds). Oxford University Press, London, UK 1993: pp 756-771.
  13. Laxer RM, Silverman ED: Systemic lupus erythematosus and the cardiovascular system in childhood. In: Current Opinion in Pediatrics. Volume 3 Lippincott Williams & Wilkins, Philadelphia, PA 1991: pp 832-837.
  14. Laxer RM, Schaffer FM, Myones B, Rowe R, Silverman ED: Lymphocyte abnormalities and complement activation in Kawasaki disease. In: 2nd International Symposium on Kawasaki Disease Alan R. Liss Publication, 1987: pp 175-184.
  15. Laxer RM, Shore AD, Silverman ED: Drug therapy in juvenile rheumatoid arthritis. In: Proceedings of the International Rheumatology Conference (Kean WF, ed). Medicopea International Inc., 1987: pp 145-154.
  16. Kaufman DB, Laxer RM, Silverman ED, Stein LD: Systemic lupus erythematosus in childhood and adolescence. In: Current Problems in Pediatrics Mosby, 1986.

Contact Information

Admin Assistant
Sandra Bergeron
e-mail: sandra.bergeron@sickkids.ca

Mailing Address
The Hospital for Sick Children
555 University Ave.
Room 8251, Black Wing
Toronto, ON M5G 1X8

Tel.: (416) 813-6249
Fax: (416) 813-4989
e-mail: earl.silverman@sickkids.ca