Baruchel Lab
Principal Investigator
Sylvain Baruchel, MD
Scientific Profile
Research Associates
Diana Stampak
Lebow Zhang
Clinical Research Program Director
Janet Gammon
Research Activities
Dr. Baruchel's research program is focused on clinical/research interests are in the area of experimental therapies in children with cancer and serious blood disorders with a particular focus on phase I/II studies, that include angiogenesis and signal transduction inhibitor-related research, clinical pharmacology, nutritional pharmacology, glutathione-related drug resistance and immunodeficiency, new agent and pharmacology, and clinical trial methodology
Publications
Stempak D, Seely D, Baruchel S: Metronomic dosing of chemotherapy: applications in pediatric oncology. Cancer Investigation 2006: 24(4): pp 432-43.
Baruchel S: Low-Dose Metronomic Chemotherapy: Myth or Truth? Onkologie 2006: 29: pp 305-307.
Lau L, Supko JG, Blaney S, Hershon L, Seibel N, Krailo M, Qu W, Malkin D, Jimeno J, Berstein M, Baruchel S: A Phase I and Pharmacokinetic Study of Ecteinascidin-743 (Yondelis) in Children with Refractory Solid Tumors. A Children's Oncology Group Study. Clinical Cancer Research 2005: 11(2 Pt 1): pp 672-7.
Das B, Yeger H, Tsuchida R, Torkin R, Gee MF, Thorner PS, Shibuya M, Malkin D, Baruchel S: A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1 alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma. Cancer Research 2005: 65(16): pp 7267-75.
Barrera M, D'Agostino N, Gammon J, Spencer L, Baruchel S: Health-related quality of life and enrollment in Phase 1 trials in children with incurable cancer. Pallative and Supportive Care 2005: 3(3): pp 191-6
Gee M F, Tscuhida R, Das B, Eichler-Jonsson C, Baruchel S, Malkin D: Vascular endothelial growth factor acts in an autocrine manner in rhabdomyoscarcoma cell lines and can be inhibited with All-trans-retinoic acid. Oncogene 2005: 24(54): pp 8025-37.
Lau L, Baruchel S: "Can Canada sustain paediatric oncology phase I trials?" A national survey of cancer relapse in children. Canadian Journal of Clinical Pharmacology 2005: 12(3): pp 222-8.
Stevens B, Yamada J, Epstein I, Bilodeau M, Baruchel S: Adventure Therapy for Adolescents with Cancer. Pediatric Blood and Cancer 2004: 43 (3): pp 278-84.
Das B, Yeger H, Koren G, Freedman MH, Baruchel S: In vitro cytoprotective activity of squalene in a bone marrow versus neuroblastoma model of cis-platinum toxicity: its implications for pediatric cancer chemotherapy. European Journal of Cancer 2003: 39 (17): pp 2556-65
Hargrave D, Gammon J, Bouffet E, Becker L, Rutka J, Baruchel S: Response to low dose temozolomide in radiation induced gliomatosis cerebri. Medical and Pediatric Oncology 2003: 41 (6): pp 562-4.
Contact Information
Admin Assistant
Connie Grillo
e-mail: connie.grillo@sickkids.ca
Mailing Address
The Hospital for Sick Children
555 University Ave.
Room 9418, Black Wing
Toronto, ON M5G 1X8
Tel: (416) 813-7795
Fax: (416) 813-5327
e-mail: sylvain.baruchel@sickkids.ca