Brief Biography

Dr. Douglas Cheyne received his PhD from Simon Fraser University in 1988. Dr. Cheyne is a neuroimaging scientist with a specialization in Magnetoencephalography (MEG). His postdoctoral work at the Neurological Clinical at Vienna General Hospital focused on the application of MEG to the study of human motor control. Dr. Cheyne subsequently worked in the MEG industry in Canada and has held adjunct appointments in Kinesiology and Psychology at Simon Fraser University. He joined the SickKids Research Institute as a Senior Scientist in 2001. Dr. Cheyne
 is an Associate Professor of Medical Imaging at the University of Toronto with cross-appointments in the Institutes of Biomaterials 
and Biomedical Engineering and Medical Sciences. His current research is focused on the advancement of neuroimaging techniques for the diagnosis of childhood epilepsy, presurgical functional mapping, and the study of sensory, motor and cognitive processes and their impairments in children, and is supported by grants from CIHR, NSERC, and the Canadian Foundation for Innovation. 

Research Interests

• Imaging techniques in neuroscience (EEG, MEG and fMRI)
• Mathematical modeling of the electrical activity of the brain
• Motor and sensory systems
• Cognitive neuroscience

Research Activities

Dr. Cheyne's research is focused on the development of neuroimaging methods using Magnetoencephalography (MEG) – a new imaging technology that monitors brain function, non-invasively, by detecting small magnetic fields produced by neural activity. He uses mathematical models to localize the generators of the measured fields to produce images of activity patterns throughout the brain. This neuromagnetic imaging method has applications in the diagnosis of abnormal brain activity in disorders such as childhood epilepsy, as well as aiding in the localization of various functional cortical areas prior to surgery. His laboratory is currently developing new analysis methods for the application of neuromagnetic imaging to the study of various sensory, motor and cognitive processes and their impairments in adults and children.

Future Research Interests

Projects currently underway include: development of MEG imaging methods for cognitive brain imaging; application of MEG techniques in epilepsy; measuring cortical oscillatory activity associated with proprioception and movement; localization of neural activity associated with visual motion and visuomotor integration.

For more information visit Cheyne Lab.

External Funding

• Natural Sciences and Engineering Research Council of Canada (NSERC)
• Canadian Institutes of Health Research (CIHR)
• Canadian Foundation for Innovation

Publications

Lennert T., Cipriani, R., Jolicoeur P., Cheyne D., Martinez-Trujillo JC. (2011) Attentional modulation of neuromagnetic evoked responses in early human visual cortex and parietal lobe following a rank-order rule. Journal of Neuroscience 31:17622-17636 .

Mohamed IS., Otsubo H., Ferrari P., Ochi A., Snead OC., Cheyne D. (2011) Neuromagnetic cerebellar activation during seizures arising form the motor cortex. Epilepsy Research 96:283-287.

Lalancette M., Quraan M., Cheyne D. (2011) Evaluation of multiple sphere head models for MEG source localization. Physics in Medicine and Biology 56: 521-5635.

Wennberg R., Valiante T., Cheyne D.  (2011) EEG and MEG in mesial temporal lobe epilepsy. Where do the spikes really come from? Clinical Neurophysiology 122:1295-1313

Beal D., Quraan M., Cheyne D., Taylor MJ, DeNil L. (2011) Speech induced suppression of evoked auditory fields in children who stutter: a magnetoencephalography study. NeuroImage 54: 2994-3003.

Popovitch C, Dockstader C., Cheyne D., Tannock R. (2010) Sex differences in sensorimotor mu rhythms during selective attentional processing.  Neuropsychologia 48: 4102-4110.

Robitaille N., Marois R., Todd J., Grimault S., Cheyne D., Jolicoeur P. (2010) Distinguishing between lateralized and nonlateralized brain activity associated with visual short-term memory:  fMRI, MEG, and EEG evidence from the same observers. NeuroImage 53: 1334-1345.

Beal D., Cheyne D., Gracco V. Quraan M., Taylor MJ. DeNil L. (2010) Auditory evoked responses to vocalization during passive listening and active generation in adults who stutter. NeuroImage 52: 1645-1653.

Gaetz W., MacDonald M., Cheyne D. Snead OC (2010) Neuromagnetic imaging of movement-related cortical oscillations in children and adults: age predicts post-movement beta rebound. NeuroImage: 51: 792-807.

Vakorin V., Ross B., Krakovska O., Bardouille T., Cheyne D. McIntosh A.R. (2010) Posterior parietal cortex revealed by complexity analysis of the neuromagnetic somatosensory steady-state response. NeuroImage 51: 83-90.

Virji-Babul N., Moiseev A., Cheung T. Weeks D. Cheyne D, Ribary U. (2010) Spatial-temporal dynamics of cortical activity underlying reaching and grasping. Human Brain Mapping 31:160-171.

Quraan M. and Cheyne D. (2010) Reconstruction of correlated brain activity with adaptive spatial filters in MEG. NeuroImage 49: 2387-2400.

Dockstader C., Gaetz W., Cheyne D. Tannock R.  (2009) Abnormal neural reactivity to unpredictable sensory events in Attention Deficit/Hyperactivity Disorder Biological Psychiatry 66: 376-383.

Gaetz W., Cheyne D., Drake J., Rutka J., Benifla M., Strantzas S., Widjaja E., Holowka S., Otsubo H., Pang E.W.  (2009) Pre-surgical localization of primary motor cortex in paediatric patients with brain lesions using spatially filtered magnetoencephalography. Neurosurgery 64 (3): 177-186.

Cheyne D., Bells S., Ferrari P., Gaetz W., Bostan AC. (2008) Self-paced movements induce high-frequency gamma oscillations in primary motor cortex.  NeuroImage 42:332-342.

Cheyne D, Bells S, Ferrari P, Gaetz W, Bostan AC. (2008) Self-paced movements induce high-frequency gamma oscillations in primary motor cortex. NeuroImage 42:332-342.

Pang EM, Drake JM, Otsubo H, Martineau A, Strantzas S, Cheyne D, Gaetz W. (2008) Interoperative confirmation of hand motor area identified preoperatively by magnetoencephalography: a clinical case study. Pediatric Neurosurgery 44:313-317.

Virji-Babul N, Moiseev A, Cheung T, Weeks D, Cheyne D, Ribary U. (2008) Changes in Mu rhythm during action observation and execution in adults with Down syndrome: implications for action representation. Neuroscience Letters 436: 177-180.

Sutcliffe TL, Gaetz W, Logan W, Cheyne D, Fehlings DL. (2007) Cortical reorganization after modified constraint-induced therapy in pediatric hemiplegic cerebral palsy. Journal of Child Neurology 22: 1281-1287.

Cheyne D, Bostan AC, Gaetz W, Pang EW. (2007) Event-related beamforming: a robust method for presurgical functional mapping using MEG. Clinical Neurophysiology 118:1691-1704.

Herdman T, Pang E, Gaetz W, Ressl V, Cheyne D. (2007) Spatiotemporal dynamics of neuromagnetic responses related to language production. Cerebral Cortex 17: 2536-2543.

Martinez-Trujillo J, Cheyne D, Gaetz W, Simine E, Tsotsos J. (2007) Activation of MT/V5+ and right inferior parietal cortex during the detection of transient direction changes in translational motion. Cerebral Cortex 17:1733-1739.

Itier RJ, Herdman AT, George N, Cheyne D, Taylor MJ. (2006) Inversion and contrast-reversal effects of face processing assessed by MEG. Brain Research 1115: 108-120.

Cheyne D, Bakhtazad L, Gaetz W. (2006) Spatiotemporal mapping of cortical activity accompanying voluntary movements using an event-related beamforming approach. Human Brain Mapping 27: 213-229.

Kelso JAS, Fuchs A, Lancaster R, Holroyd T, Cheyne D, Weinberg H. (1998) Dynamic cortical activity in the human brain reveals motor equivalence. Nature 392: 814-818.