About Sickkids
About SickKids

Douglas Cheyne, PhD

The Hospital for Sick Children
Associate Scientific Staff
Neurology

Research Institute
Senior Scientist
Neurosciences & Mental Health

University of Toronto
Professor,
Institute for Biomaterials and Biomedical Engineering

Professor,
Department of Medical Imaging

Professor,
Department of Speech-Language Pathology


Phone: 416-813-2168
Fax: 416-813-7362
e-mail: douglas.cheyne@sickkids.ca

Brief Biography

Dr. Douglas Cheyne received his PhD from Simon Fraser University in 1988. Cheyne is a neuroimaging scientist with a specialization in Magnetoencephalography (MEG). His postdoctoral work at the Neurological Clinical at Vienna General Hospital focused on the application of MEG to the study of human motor control. Cheyne subsequently worked in the MEG industry in Canada and has held adjunct appointments in Kinesiology and Psychology at Simon Fraser University. He joined the SickKids Research Institute as a Senior Scientist in 2001. Cheyne
 is a Professor of the Department of Medical Imaging at the University of Toronto with cross-appointments in the Institutes of Biomaterials 
and Biomedical Engineering and Medical Sciences. His current research is focused on the advancement of neuroimaging techniques for the diagnosis of childhood epilepsy, presurgical functional mapping, and the study of sensory, motor and cognitive processes and their impairments in children.

Research Interests

Research Activities

Cheyne's research is focused on the development of neuroimaging methods using Magnetoencephalography (MEG) – a new imaging technology that monitors brain function, non-invasively, by detecting small magnetic fields produced by neural activity. He uses mathematical models to localize the generators of the measured fields to produce images of activity patterns throughout the brain. This neuromagnetic imaging method has applications in the diagnosis of abnormal brain activity in disorders such as childhood epilepsy, as well as aiding in the localization of various functional cortical areas prior to surgery. His laboratory is currently developing new analysis methods for the application of neuromagnetic imaging to the study of various sensory, motor and cognitive processes and their impairments in adults and children.

For more information visit Dr. Cheyne's lab website.

External Funding

  • Natural Sciences and Engineering Research Council of Canada (NSERC)
  • Canadian Institutes of Health Research (CIHR)
  • Canadian Foundation for Innovation
  • Ontario Brain Institute

Publications

2015
1. Isabella S., Ferrari P., Jobst, C., Cheyne JA., Cheyne D. Complementary roles of cortical oscillations in automatic and controlled processing during a rapid serial task. NeuroImage 118:268-281
2. Chevrier A., Cheyne D., Graham S., Schachar R. (2014) Dissociating two stages of preparation in the stop signal task using fMRI. PLoS ONE 10(6) e0130992.

2014
1.  Cheyne D., Jobst C., Tesan G., Crain S., Johnson B. (2014) Movement-related neuromagnetic fields in preschool age children Human Brain Mapping 35: 4858-4875.
2.  Wennberg R, Cheyne D. Reliability of MEG source imaging of anterior temporal spikes: validation with intracranial recordings. Clinical Neurophysiology 125: 903-918.
3.  Wennberg R, Cheyne D. EEG source imaging of anterior temporal lobe spikes: Validity and reliability, Clinical Neurophysiology 125: 866-902.

2013
1.  Cheyne D, Fehlings, D Can neuroimaging help identify effective strategies for constraint therapy in congenital hemiparesis? Commentary.  Developmental Medicine and Child Neurology 55: 882-883.
2.  Cheyne D., Ferrari, P. MEG studies of motor cortex gamma oscillations: Evidence for a gamma “fingerprint” in the brain? Frontiers in Human Neuroscience 7:575.
3.  Mohamed IS., Otsubo H., Ferrari P., Ochi A., Elliot I., Go C., Akiyama T., Chuang S., Rutka J., Snead OC., Cheyne D. Source localization of interictal spike-locked neuromagnetic oscillation in pediatric neocortical epilepsy.  Clinical Neurophysiology 124: 1517—1527.
4.  Alikhanian H., Crawford JD., DeSouza JFX., Cheyne D. Blohm G. Machine learning approach for functional localization using magnetoencephalography.  Frontiers in Neuroscience. 7:73
5.  Wennberg R, Cheyne D. On noninvasive source imaging of the human K-complex. Clinical Neurophysiology 124: 941-955.
6.  Cheyne D.  MEG studies of sensorimotor rhythms. A review. Experimental Neurology 245: 27-39.

2012
1.  Cheyne D., Ferrari P., Cheyne JA.  Intended actions and unexpected outcomes: Automatic and controlled processing in a rapid motor task. Frontiers in Human Neuroscience 6: 236.
2.  Memarian N., Ferrari P.,  MacDonald M., Cheyne D., De Nil L., Pang E.W.  Cortical activity during speech and non-speech oromotor tasks: A magnetoencephalography (MEG) study. Neuroscience Letters 527: 34-39.

2011
1.  Lennert T., Cipriani, R., Jolicoeur P., Cheyne D., Martinez-Trujillo JC. Attentional modulation of neuromagnetic evoked responses in early human visual cortex and parietal lobe following a rank-order rule. Journal of Neuroscience 31:17622-17636 .
2.  Mohamed IS., Otsubo H., Ferrari P., Ochi A., Snead OC., Cheyne D.  Neuromagnetic cerebellar activation during seizures arising form the motor cortex. Epilepsy Research 96:283-287.
3.  Lalancette M., Quraan M., Cheyne D. Evaluation of multiple sphere head models for MEG source localization. Physics in Medicine and Biology 56: 5621-5635.
4.  Wennberg R., Valiante T., Cheyne D.  EEG and MEG in mesial temporal lobe epilepsy. Where do the spikes really come from? Clinical Neurophysiology 122:1295-1313
5.  Beal D., Quraan M., Cheyne D., Taylor MJ, DeNil L. Speech induced suppression of evoked auditory fields in children who stutter: A magnetoencephalography study. NeuroImage 54: 2994-3003.

2010
1.  Popovitch C, Dockstader C., Cheyne D., Tannock R. Sex differences in sensorimotor mu rhythms during selective attentional processing. Neuropsychologia 48: 4102-4110.
2.  Robitaille N., Marois R., Todd J., Grimault S., Cheyne D., Jolicoeur P. Distinguishing between lateralized and nonlateralized brain activity associated with visual short-term memory:  fMRI, MEG, and EEG evidence from the same observers. NeuroImage 53: 1334-1345.
3.  Beal D., Cheyne D., Gracco V. Quraan M., Taylor MJ. and DeNil L. Auditory evoked responses to vocalization during passive listening and active generation in adults who stutter. NeuroImage 52:1645-1653.
4.  Gaetz W., MacDonald M., Cheyne D. and Snead OC  Neuromagnetic imaging of movement-related cortical oscillations in children and adults: Age predicts post-movement beta rebound. NeuroImage: 51:792-807.
5.  Vakorin V., Ross B., Krakovska O., Bardouille T., Cheyne D. and McIntosh A.R. Complexity analysis of source activity underlying the neuromagnetic somatosensory steady-state response. NeuroImage 51: 83-90.
6.   Virji-Babul N., Moiseev A., Cheung T. Weeks D. Cheyne D, and Ribary U., Neural mechanisms underlying action observation in adults with Down syndrome. American Journal on Intellectual and Developmental Disabilities 2:113-127.
7.  Hung Y., Smith ML., Bayle D., Mills T., Cheyne D. and Taylor M. Unattended emotional faces elicit early lateralized amygdala-frontal and fusiform activations. NeuroImage 50:727-733.
8.   Virji-Babul N., Moiseev A., Cheung T. Weeks D. Cheyne D, and Ribary U.  Spatial-temporal dynamics of cortical activity underlying reaching and grasping. Human Brain Mapping 31:160-171.
9.  Quraan M. and Cheyne D. Reconstruction of correlated brain activity with adaptive spatial filters in MEG. NeuroImage 49: 2387-2400.