Facebook Pixel Code
About Sickkids
About SickKids

Thomas Eiwegger, MD

The Hospital for Sick Children
Staff Physician, Clinical Immunology & Allergy
Immunology & Allergy

Research Institute
Scientist, Physiology & Experimental Medicine
Research Institute

University of Toronto
Associate Professor
Paediatrics

Associate Professor
Immunology


Phone: 416 813-7654 ext. 201862
Email: thomas.eiwegger@sickkids.ca
Alternate Contact: Sandra Mendonca
Alternate Phone: 416 813-7654 ext. 208626
Alternate Email: sandra.mendonca@sickkids.ca

Brief Biography

Thomas Eiwegger earned his doctoral degree at the Medical University of Vienna, Austria, where he also completed his paediatric training. He did his post doctoral training in the Swiss Institute of Asthma and Allergy in the group of Cezmi Akdis from 2008 to 2010 and after returned to the Medical University of Vienna where he trained in paediatric allergy and respiratory medicine. Before moving to Sickkids, Eiwegger was Principal Investigator and Associate Professor at the Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Austria.

Research Interests

Developing and facilitating new concepts in the treatment of food allergy

Eiwegger’s main interests are mechanisms of IgE-mediated allergy. He will focus in particular on a better understanding of the mechanisms of tolerance development to food allergens and markers thereof. Eiwegger will define new treatment approaches by delineating the sequence of events that take place in children that lose their food allergy.

Publications

Saidova A, Hershkop AM, Ponce M, Eiwegger T. Allergen-Specific T Cells in IgE-Mediated Food Allergy. Arch Immunol Ther Exp (Warsz) 2017 in press.

Gona-Hopler M, Pfaller B, Argeny J, Kanolzer S, Gruber S, Schmidthaler K, et al. Aspergillus fumigatus-specific immunoglobulin levels in BALF of CF patients. ERJ Open Res 2017; 3.

Diesner SC, Lukas J, Stifter E, Raimann A, Nachbaur E, Eiwegger T, Renner S, Geleff S, Emminger W, Szépfalusi Z. Bilateral infiltrative dacryoadenitis and granulomatous pneumonia in an 11-year old boy: a case report. Klin Padiatr 2017; 229:96-9.

Diesner SC, Bergmayr C, Pfitzner B, Assmann V, Krishnamurthy D, Starkl P, Endesfelder D, Rothballer M, Welzl G, Rattei T, Eiwegger T, Szépfalusi Z, Fehrenbach H, Jensen-Jarolim E, Hartmann A, Pali-Schöll I, Untersmayr E, A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model. Clin Immunol. 2016 Dec;173:10-18. doi: 10.1016.

Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA: Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases. J Allergy Clin Immunol 2016;138:984-1010

Broekman HCH, Eiwegger T, Upton J, Bogh KL. IgE – The Main Player of Food Allergy. Drug Discovery Today: Disease Models – October 2016. DOI: 10.1016/j.ddmod.2016.07.001.

Hansen CS, Hansen CS, Dufva M, Bøgh KL, Sullivan E, Patel J, Eiwegger T, Szépfalusi Z, Nielsen M, Christiansen A, Linear epitope mapping of peanut allergens demonstrates individualized and persistent antibody binding patterns, Journal of Allergy and Clinical Immunology  (2016), doi: 10.1016/ j.jaci.2016.06.019.

Ponce M, Diesner SC, Szepfalusi Z, Eiwegger T, Markers of tolerance development to food allergens. 2016 Oct;71(10):1393-404. doi: 10.1111/all.12953

Angelina A, Sirvent S, Palladino C, Vereda A, Cuesta-Herranz J, Eiwegger T, Rodriguez R, Breitendeder H, Villalba M, Palomares O. The Lipid-interaction capacity of Sin a 2 and Ara h 1, major mustard and peanut allegens of the cupin superfamily, endorses allergenicity. Allergy. 2016 Mar 17 doi 1111/all.12887 (epub ahead of print).

O’Mahony L, Akdis CA, Eiwegger T. Innate mechanisms can predict successful allergy immunotherapy. J Allergy Clin Immunol. 2016 Feb, 137(2):559-61.

Christiansen A, Kringelum JV, Hansen CS, Bogh KL, Sullivan E, Patel J, Rigby NM, Eiwegger T, Szepfalusi Z, de Masi F, Nielsen M, Lund O, Dufva M. High-throughput sequencing enhanced phage display enables the identification of patient-specific epitope motifs in serum. Sci Rep 2015; 5: 12913.

Soyka MB, Holzmann D, Basinski TM, Wawrzyniak M, Bannert C, Bürgler S, Akkoc T, Treis A, Rückert B, Akdis M, Akdis CA, Eiwegger T. The induction of IL-33 in the sinus epithelium and its influence on T-helper cell responses. PlosOne 2015; 10: e0123163.

Boyman O, Kaegi S, Akdis S, Bavbek S, Bossios A, Chatzipetrou A, Eiwegger T, Firinu D, Harr T, Knol E, Matucci A, Palomares O, Schmidt-Weber C, Simon HU, Steiner UC, Vultaggio A, Akdis CA and Spertini F. EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders. Allergy 2015; 70(7): 727-754.

Upton J, Eiwegger T. How Long Should We Go. Int Arch Allergy Immunol. 2015;168(3):147-9: doi: 10.1159/000443764. Epub 2016 Jan 21.

Ackerbauer D, Bublin M, Radauer C, Varga EM, Hafner C, Ebner C, Szépfalusi Z, Fröschl R, Hoffmann-Sommergruber K, Eiwegger T, Breiteneder H. Component-resolved IgE profiles in Austrian patients with suspected peanut allergy. Int Arch Allergy Immunol 2015;166:13-24.

Szepfalusi Z, Bannert C, Ronceray L, Mayer E, Hassler M, Wissmann E, Dehlink E, Gruber S, Graf A, Lupinek C, Valenta R, Eiwegger T, Urbanek R. Preventive sublingual immunotherapy in preschool children: first evidence for safety and pro-tolerogenic effects. Pediatr Allergy Immunol 2015; 25:788-795.

Martin-Fontecha M, Eiwegger T, Jartti T, Rueda-Zubiaurre A, Tiringer K, Stepanow J, Puhakka T, Ruckert B, Ortega-Gutierrez S, Lopez-Rodriguez ML, Akdis M, Akdis CA, Palomares O. The expression of cannabinoid receptor 1 is significantly increased in atopic patients. J Allergy Clin Immunol 2014; 133: 926-929 e922.

Bublin M, Eiwegger T, Breiteneder H. Do lipids influence the allergic sensitization process? J Allergy Clin Immunol 2014.

Bogh KL, Nielsen H, Eiwegger T, Madsen CB, Mills EN, Rigby NM, Szepfalusi Z, Roggen EL. IgE versus IgG4 epitopes of the peanut allergen Ara h 1 in patients with severe allergy. Mol Immunol 2014; 58: 169-176.

Tiringer K, Treis A, Kanolzer S, Witt C, Chanim B, Gruber S, Schmidthaler K, Renner S, Dehlink E, Nachbaur E, Frischer T, Klepetko W, Akdis CA, Szepfalusi Z, Eiwegger T. Differential expression of IL-33 and HMGB1 in the lungs of stable cystic fibrosis patients. Eur Respir J. 2014 Sep;44(3):802-5. doi:10.1183/09031936.00046614.

Tiringer K, Treis A, Fucik P, Gona M, Gruber S, Renner S, Dehlink E, Nachbaur E, Horak F, Jaksch P, Doring G, Crameri R, Jung A, Rochat MK, Hormann M, Spittler A, Klepetko W, Akdis CA, Szepfalusi Z, Frischer T, Eiwegger T. A Th17- and Th2-skewed cytokine profile in cystic fibrosis lungs represents a potential risk factor for pseudomonas aeruginosa infection. Am J Respir Crit Care Med 2013;187:621-629.

Prelog M, Schonlaub J, Jeller V, Almanzar G, Hofner K, Gruber S, Eiwegger T, Wurzner R. Reduced varicella-zoster-virus (VZV)-specific lymphocytes and IgG antibody avidity in solid organ transplant recipients. Vaccine 2013;31:2420-2426.

Diesner SC, Gruber S, Dehlink E, Muhlebner A, Eiwegger T, Szepfalusi Z. Somnolence upon allergen provocation in a child with hen's egg allergy. Klin Padiatr 2013.
24. Soyka MB, Wawrzyniak P, Eiwegger T, Holzmann D, Treis A, Wanke K, Kast JI, Akdis CA. Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by ifn-gamma and IL-4. J Allergy Clin Immunol 2012;130:1087-1096 e1010.

Soyka MB, Treis A, Eiwegger T, Menz G, Zhang S, Holzmann D, Akdis CA, Meyer N. Regulation and expression of il-32 in chronic rhinosinusitis. Allergy 2012;67:790-798.

Meyer N, Christoph J, Makrinioti H, Indermitte P, Rhyner C, Soyka M, Eiwegger T, Chalubinski M, Wanke K, Fujita H, Wawrzyniak P, Burgler S, Zhang S, Akdis M, Menz G, Akdis C. Inhibition of angiogenesis by il-32: Possible role in asthma. J Allergy Clin Immunol 2012;129:964-973 e967.

Mayer E, Bannert C, Gruber S, Klunker S, Spittler A, Akdis CA, Szepfalusi Z, Eiwegger T. Cord blood derived cd4+ cd25(high) t cells become functional regulatory t cells upon antigen encounter. PLoS One 2012;7:e29355.

Gruber S, Eiwegger T, Nachbaur E, Tiringer K, Aigner C, Jaksch P, Keplinger M, Klepetko W, Lang G, Taghavi S, Graf A, Eichler I, Frischer T, Szepfalusi Z. Lung transplantation in children and young adults: A 20-year single-centre experience. Eur Respir J 2012;40:462-469.

Eiwegger T, Gruber S, Szepfalusi Z, Akdis CA. Novel developments in the mechanisms of immune tolerance to allergens. Hum Vaccin Immunother 2012;8:1485-1491.

Bogh KL, Nielsen H, Madsen CB, Mills EN, Rigby N, Eiwegger T, Szepfalusi Z, Roggen EL. Ige epitopes of intact and digested ara h 1: A comparative study in humans and rats. Mol Immunol 2012;51:337-346.