Paul Frankland, PhD
Neurosciences & Mental Health
University of Toronto
Department of Physiology
Phone: 416-813-7654 ext.1823
- learning and memory
- genetically-engineered mice
- mouse models of inherited disease associated with cognitive dysfunction
- memory consolidation
The general goal of our research program is to understand how our brains normally encode, store and retrieve information. By combining mouse-genetic, molecular biology, immunohistochemical and behavioral approaches we currently focus on two major questions:
- First, to understand how memories are initially encoded in the hippocampus, and, in particular, how adult neurogenesis might contribute to this process.
- Second, to understand how these memories are subsequently transformed into lifelong (or remote) memories in the cortex for long-term storage.
Understanding how these basic processes work is an essential stepping stone in developing more effective treatment strategies for memory dysfunction, whether associated with normal aging, disorders such as Alzheimer’s disease, or resulting from stroke or trauma
- Canadian Institutes of Health Research (CIHR)
- EJLB Foundation
- Early Researcher Award
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- Natural Sciences and Engineering Research Council (NSERC)
- France-Canada Research Foundation
Wang SH, Teixeira CM, Wheeler AL, Frankland PW. (2009). The precision of remote contextual memories does not require the hippocampus. Nature Neuroscience, 12, 253-255.
Kee N*, Teixeira CM*, Wang AH*, Frankland PW. (2007). Imaging activation of adult-generated granule cells in spatial memory. Nature Protocols, 12, 3033-3044. *equal contribution
Kee N*, Teixeira CM*, Wang AH, Frankland PW. (2007). Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nature Neuroscience, 10, 355-362. *equal contribution
Teixeira CM, Pomedli S, Maei HR, Kee N, Frankland PW. (2006). Involvement of the anterior cingulate cortex in the expression of remote spatial memory. The Journal of Neuroscience, 26, 7555-7564.
Frankland PW, Bontempi B. (2005). The organization of recent and remote memory. Nature Reviews Neuroscience, 6, 119-130.
Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Silva AJ. (2004). The involvement of the anterior cingulate cortex in remote contextual fear memory. Science, 304 (5671), 881-883.