About Sickkids
About SickKids
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Elizabeth Pang , PhD

The Hospital for Sick Children
Neurophysiologist
Neurology

Research Institute
Associate Scientist
Neurosciences & Mental Health

University of Toronto
Assistant Professor
Department of Paediatrics


Phone: 416-813-6548
Fax: 416-813-6334
e-mail: elizabeth.pang@sickkids.ca

Brief Biography

Dr. Pang obtained her PhD in psychology from York University in 1997. For her doctoral dissertation, she examined the effects of different pharmacological agents on event-related brain potentials associated with auditory processing and auditory attention. She proceeded to complete a post-doctoral fellowship at the Hospital For Sick Children where she tracked the developmental course of auditory event-related potentials associated with the processing of speech and non-speech stimuli. Currently, her interests involve using auditory event-related potentials to examine diseases with dysfunctional auditory processing.

Clinical Care Activities

Clinical evoked potentials and magnetoencephalography (MEG).

Areas of Specialty:
Neurophysiology – evoked potential studies

Research Interests

  • describing the development of auditory processing in normal children using evoked potentials (EP) and event-related potentials (ERP) obtained from electroencephalographic measures (EEG) as well as magnetic evoked fields obtained from the magnetoencephalogram (MEG)
  • tracking the development of auditory processing by using brain electrical source analysis (BESA) to correlate components of the auditory evoked response with their underlying neural generators
  • examining auditory processing in children with Landau-Kleffner syndrome and autism spectrum disorder to test whether there are consistent patterns of dysfunction, as measured by ERPs that can serve as fingerprints for the various disorders
  • using ERPs to examine higher cognitive functions such as speech, language and math processing

Future Research Interests

To use ERPs and MEG to differentiate degrees of auditory processing dysfunction in children, and then use this information to characterize subgroups along the spectrum of autistic disorder.

External Funding

Canadian Institutes for Health Research

Taylor MJ, Doesburg S, Agnagnostou E, Pang EW. (2012 - 2017). 
Development of frontal lobe cognitive functions: timing, structure and connectivity.  Canadian Institutes of Health Research.

Cheyne D, Chau T, Van Lieshout P, Steele C, Pang E, Donner E. (2010-2013). 
Development of an MEG-compatible articulography system for the assessment of brain function and oromotor dynamices.  Collaborative Health Research Projects, Canadian Institutes of Health Research.

Pang EW, Cheyne D, De Nil L, Roberts SW. (2008 – 2013).
Dissociating cognitive and motor components of healthy and dysfunctional expressive language development in children.

Taylor MJ, Pang EW, Donner EJ. (2006-2011).
Multimodal neuroimaging of frontal lobe cognitive function in children.

Publications

Doesburg SM, Ibrahim GM, Smith ML, Sharma R, Viljoen A, Chu B, Rutka JT, Snead OC, Pang EW. (2013) Altered Rolandic Gamma-Band Activation Associated with Motor Impairment and Ictal Network Desynchronization in Childhood Epilepsy. PLoS ONE 8(1): e54943. doi:10.1371/journal.pone.0054943.

Memarian N, Ferrari P, MacDonald MJ, Cheyne D, De Nil LF, Pang EW. (2012). Cortical activity during speech and non-speech oromotor tasks: a magnetoencephalography (MEG) study.  Neuroscience Letters, 527, 34-39.

Pang EW, MacDonald MJ. (2012). An MEG study of the spatiotemporal dynamics of bilingual verb generation. Brain Research, in press. Brain Research, 1467, 56-66.

Doesburg SM, Vinette SA, Cheung MD, Pang EW. (2012). Theta- modulated gamma-band synchronization during a verb generation task. Frontiers in Psychology, 3, 195, doi: 10.3389/fpsyg.2012.00195.

Pang EW. (2012). Neuroimaging studies of bilingual language representation in the brain: focus on MEG. Neuroscience Bulletin, 28(6): 759-764

Vidal J, Mills T, Pang EW, Taylor MJ. (2012). Response inhibition in adults and teenagers: Spatiotemporal differences in the prefrontal cortex. Brain and Cognition, 79, 49-59.

Taylor MJ, Donner EJ, Pang EW. (2012). fMRI and MEG in the study of typical and atypical cognitive development. Neurophysiologie Clinique / Clinical Neurophysiology, 42, 19-25.

Taylor MJ, Mills T, Pang EW. (2011). The development of face recognition; hippocampal and frontal lobe contributions determined by MEG. Brain Topography, 24(3-4):261-70.

Pang EW. (2011). Practical aspects of running development studies in the MEG. Brain Topography, 24(3-4):253-60.

Pang, EW. (Ed.). (2011). Magnetoencephalography.  Rijeka, Croatia: Intech. (ISBN 978-953-307-255-5).(download at: http://www.intechopen.com/books/magnetoencephalography)

Kadis DS, Pang EW, Mills T, Taylor MJ, McAndrews MP, Smith ML. (2011). Characterizing the normal developmental trajectory of expressive language lateralization using magnetoencephalography. Journal of the International Neuropsychological Society, 17, 896-904.

Taylor MJ, Bayless SJ, Mills T, Pang EW. (2011). Recognising upright and inverted faces: MEG source localization. Brain Research, 1381, 167-174

Bomba MD, Choly D, Pang EW. (2011). Phoneme discrimination and mismatch negativity in English and Japanese speakers.  Neuroreport, 22, 479-483.

Pang EW, Wang F, Malone M, Kadis DS, Donner EJ. (2011). Localization of Broca¹s area using verb generation tasks in the MEG:
validation against fMRI.
 Neuroscience Letters, 490, 215-219.

Pang EW, Gaetz W, Drake JM, Strantzas S, MacDonald MJ, Otsubo H, Snead OC. (2009). Patient with post-central gyrectomy demonstrates reliable localization of hand motor area using magnetoencephalography
(MEG): Case Report. Pediatric Neurosurgery,
45:311-316.

Taylor MJ, Pang EW. (2009). Using MEG to image cognition in children. Down Syndrome Quarterly, 11, 10-17.

Gaetz W, Cheyne D, Rutka J, Drake J, Benifla M, Strantzas S, Widjaja E, Holowka S, Tovar-Spinoza Z, Otsubo H, Pang EW. (2009). Pre-surgical localization of primary motor cortex in paediatric patients with brain lesions using spatially filtered MEG. Neurosurgery (Operative Neurosurgery Supplement), 64:ons177-ons189

Bercovici E, Pang EW, Sharma R, Mohamed IS, Imai K, Fujimoto A, Ochi A, Viljoen A, Chu B, Holowka S, Chuang SH, Kemp SM, Rutka JT, Snead OC III, Otsubo H. (2008). Somatosensory evoked fields on magnetoencephalography for epilepsy infants younger than 4 years with total intravenous anesthesia. Clinical Neurophysiology, 119, 1328-1334.

Gaetz W, Otsubo H, Pang EW. (2008). Magnetoencephalography for clinical paediatrics: the effect of head positioning on measurement of somatosensory evoked fields. Clinical Neurophysiology, 119, 1923-1933.

Kadis DS, Smith ML, Mills T, Pang EW. (2008). MEG localization of expressive language cortex in healthy children: application to paediatric clinical populations. Down Syndrome Quarterly, 10(2), 5-12.

Mohamed IS, Gaetz WC, Otsubo H, Logan WJ, Snead OC, Cheyne D, Pang EW. (2008). Neuromagnetic spatiotemporal dynamics of cortical oscillations in children during an auditory word recognition task. International Journal of Psychophysiology, 68, 141-148.

Pang EW, Drake J, Otsubo H, Martineau A, Strantzas S, Cheyne D, Gaetz W. (2008). Intraoperative confirmation of hand motor area identified preoperatively by magnetoencephalography: case report. Pediatric Neurosurgery, 44, 313-317.

Taylor MJ, Mills T, Smith ML, Pang EW. (2008). Face processing in adolescents with and without epilepsy. International Journal of Psychophysiology, 68, 94-103

Cheyne D, Bostan AC, Gaetz W, Pang EW. (2007). Event-related beamforming: a robust method for presurgical functional mapping using MEG. Clinical Neurophysiology, 118, 1691–1704.

Chu B, Pang EW, Ochi A, Sharma R, Hunjan A, Holowka S, Rutka J, Weiss S, Chuang S, Snead C, Otsubo H. (2007). Extra-operative somatosensory evoked potentials confirm the accuracy of MEG SEF locations. In: Cheyne D, Ross B, Stroink G, Weinberg H (Eds.). New Frontiers in Biomagnetism. International Congress Series, 1300, 637-640.

Herdman AT, Pang EW, Ressel V, Gaetz W, Cheyne D. (2007). Task-related modulation of early cortical responses during language production: an event-related synthetic aperture magnetometry study. Cerebral Cortex, 17, 2536-2543.

Pang EW, Otsubo H, Sharma R, Hunjan A, Chu B, Snead OC. (2007). Unilateral abnormalities on MEG auditory evoked fields in children with Landau-Kleffner Syndrome. In: Cheyne D, Ross B, Stroink G, Weinberg H (Eds.). New Frontiers in Biomagnetism. International Congress Series, 1300, 65-68.

Sharma R, Pang EW, Mohamed I, Chu B, Hunjan A, Ochi A, Holowka S, Gaetz W, Chuang S, Snead OC, Otsubo H. (2007). Magnetoencephalography in children: routine clinical protocol for intractable epilepsy at the Hospital for Sick Children. In: Cheyne D, Ross B, Stroink G, Weinberg H (Eds.). New Frontiers in Biomagnetism. International Congress Series, 1300, 685-688.

Chuang NA, Otsubo H, Pang EW, Chuang SH. (2006). Pediatric magnetoencephalography and magnetic source imaging. Neuroimaging Clinics of North America,16, 193-210.

Hepworth SL, Pang EW, Rovet JF. (2006). Word and face recognition in children with congenital hypothyroidism: an event-related potential study. Journal of Clinical and Experimental Neuropsychology, 28(4), 509-527.

Mohamed IS, Otsubo H, Pang E, Chuang SH, Rutka JT, Dirks P, Weiss SK, Snead OC III. (2006). Magnetoencephalographic spike sources associated with auditory auras in pediatric localization-related epilepsy. Journal of Neurology, Neurosurgery & Psychiatry, 77(11), 1256-1261.

Otsubo H, Iida K, Oishi M, Okuda C, Ochi A, Pang E, Weiss SK, Rutka JT, Chuang SH, Snead OC 3rd. (2005). Neurophysiologic findings of neuronal migration disorders: intrinsic epileptogenicity of focal cortical dysplasia on electroencephalography, electrocorticography, and magnetoencephalography. Journal of Child Neurology, 20, 357-363.

Iida K, Otsubo H, Matsumoto Y, Ochi A, Oishi M, Holowka S, Pang E, Elliott I, Weiss SK, Chuang SH, Snead OC III, Rutka JT. (2005). Characterizing magnetic spike sources by using magnetoencephalography-guided neuronavigation in epilepsy surgery in pediatric patients. Journal of Neurosurgery (Pediatrics 2), 102, 187-196.

Bomba MD, Pang EW. (2004). Cortical auditory evoked potentials in autism: a review. International Journal of Psychophysiology, 53, 161-169.

Holwoka, SA, Otsubo H, Iida K, Pang E, Sharma R, Hunjan A, Xiang J, Snead OC III, Chuang NA, Chuang SH, Rutka JT. (2004). Three-dimensionally reconstructed magnetic source imaging and neuronavigation in pediatric epilepsy: technical note. Neurosurgery, 55, 1226.

Pang EW, Hunjan A, Sharma R, Holowka S, Otsubo H. (2002). Auditory M100 in children: developmental changes reflected in the tangential neural source. International Journal of Bioelectromagnetism, 4(2):155-156.

Pang EW, Taylor MJ. (2000). Tracking the development of the N1 from age three to adulthood: a comparison between speech and non-speech stimuli. Clinical Neurophysiology, 111:388-397.

Pang EW , Fowler B. (1999). Nitrous oxide-induced slowing can be linked to the permanent feature-detector system underlying the mismatch negativity (MMN). Psychophysiology, 36:552-558.

Taylor MJ, Pang EW. (1999). Developmental changes in early cognitive processes. Electroencephalography and Clinical Neurophysiology – Supplement, 49:145-153.