About Sickkids
About SickKids
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Mark Palmert , MD, PhD

The Hospital for Sick Children
Division Head
Endocrinology

Research Institute
Senior Associate Scientist
Genetics & Genome Biology

University of Toronto
Associate Professor
Department of Paediatrics

Phone: 416-813-6217
Fax: 416-813-6304
e-mail: mark.palmert@sickkids.ca

Brief Biography

Dr. Mark R. Palmert joined the Department of Paediatrics as head of the Division of Endocrinology in September 2007. Dr. Palmert is a graduate of the Medical Scientist Training Program at Case Western Reserve University with an MD and PhD in 1992. He trained in paediatrics and paediatric endocrinology at Children’s Hospital, Boston.

Clinical Care Activities

  1. reproductive endocrinology focusing on disorders of pubertal development
  2. care of children with general endocrine disorders and diabetes mellitus

Research Interests

Dr. Palmert conducts research in a variety of areas, but his main research activity has centred on variations in the timing and pace of pubertal development. His research program involves the combination of clinical research and an active laboratory-based program designed to identify genetic factors that modulate the timing of puberty. Dr. Palmert's second area of research focus is related to improving treatment outcomes in types 1 and 2 diabetes.

External Funding

2005 – 2011 NIH/NICHD
Genetic factors that regulate the onset of puberty. (Mark Palmert PI of RO1).

2009 –2011: Applied Client-Focused Team (ACT) Grant, St. Elizabeth's Care to Know Center
Mobile Phone-Based Self-Management System for Adolescents with Type 1 Diabetes Mellitus: A Home-based Self-care Tool that Links the Client and Family with Their Health Care Team
(Mark Palmert Co-Applicant).  

2009 – 2012: NIH/NIDDK 
DNA Methylome Study in Type I Diabetes
(Mark Palmert Co-Investigator)

2011 – 2013: Charles H. Hood Foundation   
A nested case-control study of genetic and psychosocial determinants of pubertal timing.
(Mark Palmert  Scientific Advisor)

Publications

Selected Peer Review Articles

Shulman RM, O’Gorman CS, Palmert MR.  The impact of telemedicine interventions involving routine transmission of blood glucose data with clinician feedback on metabolic control in youth with type 1 diabetes: a systematic review and meta-analysis.  International Journal of Pediatric Endocrinology.  2010; 2010.pii: 536957. Epub 2010 Sep 22.

Shao H, Sinasac D, Burrage LC, Hodges CA, Supelak PJ, Palmert MR, Moreno C, Cowley AW, Jacob HJ, and Nadeau JH.  Analyzing complex traits with congenic strains.  Mammalian Genome.  2010; 21(5-6):276-86.  Epub 2010 Jun 4.

Zhu H, Shah S, Ng S-C, Einhorn W, Shinoda G, Viswanathan S, Takeuchi A, Grassemann C, Hirschhorn J, Palmert MR, Daley GQ.  Lin28A transgenic mice manifest size and pubertal phenotypes identified in human genetic association studies.  Nature Genetics. 2010; 42(7):626-30.  Epub 2010 May 31. (Highlighted internationally as one of top papers of the year in “The Year in Female Reproduction,” 2010 Endocrine Society Mtg.)

Chiang CWK, Gajdos ZKZ, Korn JM, Kuruvilla FG, Butler JL, Hackett R, Guiducci C, Nguyen T, Wilks R, Forrester T, Haiman CA, Henderson KD, Le Marchand L, Henderson BE, Palmert MR, McKenzie CA, Lyon HN, Cooper RS, Zhu X, Hirschhorn JN.  Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples.  PloS Genetics, 2010; Mar 5;6(3):e1000866.

Gajdos ZHZ, Henderson KD, Hirschhorn JN, Palmert MR.  Genetic determinants of pubertal timing in the general population.  Invited Review.  Molecular and Cellular Endocrinology.  2010; 324(1-2):21-29. Epub Feb 6.

Koontz MB, Cuttler L, Palmert MR, O’Riordan MA, Borawski EA, McConnell J, Kern EO.   Development and validation of a questionnaire to assess carbohydrate and insulin-dosing knowledge in youth with type 1 diabetes.  Diabetes Care. 2010; 33(3):457-62.  Epub 2009 Dec 10.

Carel J-C*, Eugster EA, Rogol A, Ghizzoni L, Palmert MR*, ESPE-LWPES GnRH Analog Consensus Conference Group.  Consensus statement on the use of GnRH analogs in children.  Pediatrics.  2009; 123(4):e752-62. Epub 2009 Mar 30.  (*contributed equally) (Highlighted internationally as one of top papers of the year in Yearbook of Pediatric Endocrinology).

Hodges CA, Cotton CU, Palmert MR, Drumm ML.  Generation of a conditional null allele for CFTR in mice.  Genesis:  The Journal of Genetics and Development.  2008; 46(10):546-552. Epub 2008 Sep 18.

Hodges CA, Palmert MR*, Drumm ML*. Infertility in females with cystic fibrosis is multifactorial: evidence from mouse models. Endocrinology. 2008; 149(6): 2790-2797. Epub 2008 March 6. (*co supervisors who contributed equally).

Gajdos ZKZ, Butler JL, DeLellis Henderson K, He C, Supelak P, Egyud M, Price A, Reich D, Clayton P, Le Marchand L, Hunter DJ, Henderson BE, Palmert MR*, Hirschhorn JN*. Association studies of common variants in ten hypogonadotropic hypogonadism genes with age at menarche. J. Clin. Endocrinol. Metab. Epub August, 2008 (*co supervisors who contributed equally).

Nathan BM, Hodges CA, Supelak PJ, Burrage LC, Nadeau JH, Palmert MR. A quantitative trait locus on chromosome 6 regulates the onset of puberty in mice. Endocrinology 147(11): 5132-5138: 2006. (Epub July 27, 2006)

Selected Recent Publications (Review articles and chapters)

Shulman R, Palmert MR, Wherrett D.  Disorders of Sex Development.  In: R.J. Martin, A.A. Fanaroff and M.C. Walsh, editors. Fanaroff and Martin's Neonatal-Perinatal Medicine:  Diseases of the Fetus and Infant (9th ed). Mosby, Inc (Elsevier), St. Louis, MO; 2011; pp 1584-1620.