Margot Taylor, PhD
The Hospital for Sick Children
Director of Functional Neuroimaging
Neurosciences & Mental Health
University of Toronto
Professor of Medical Imaging
Depts. of Paediatrics and Psychology
- frontal lobe and executive function development
- effect of emotions on face processing and attention
- neuroimaging in preterm neonates and prediction of outcome
My research investigates the neural bases of cognitive development. Areas of study include development of frontal lobe or executive functions and social cognition using various protocols adapted for children. Current studies use functional MRI and MEG, as well as structural MRI, and include normative series and clinical populations (children with autism and children born very preterm. The research will determine the neural bases, temporal and spatial aspects of the development of abilities, including emotional recognition, working memory, inhibition, set-shifting, and how these cognitive skills emerge with typical and atypical development. We are also following very preterm born infants from birth to determine the impact of very early brain development on later cognitive outcome.
Working memory in children with autism.
Taylor, M.J., Smith, M.L., Lerch, J.P., Anagnostou, E. CIHR CHI, 2010-2015, 1st year: $132,064; total :$ 660,318.
Typical and atypical development of frontal lobe systems and the maturation of social cognitive function. Taylor, M.J., Pang, E.W., Doesburg, S., Anagnostou, E. . CIHR BSC, jan 2012-2016; 5-yr grant application, 1st year: $151,692 (total $766,896).
Application of Non-invasive Magnetoencephalography (MEG) for Objective Assessment of Post Traumatic Stress Disorder (PTSD): A Pilot Study. Taylor, M.J., Pang, E.W DRDC, 2012 - 2013. $248,340
Canadian Institutes of Health Research (CIHR)
Predicting Neurobehavioural outcome in preterm neonates.
Taylor MJ, Whyte H, Moore A, Shroff M, Raybaud C, Donner EJ, Frisk V. 2008-2012CIHR CHI, 2008-2012. $185,962 1st year, for a 5-year grant (total $929,129)
Centre for the Investigation of Neuroplasticity and Developmental Disorders. Canadian Foundation for Innovation (CFI).
Snead OC, Taylor MJ, Salter M, Josselyn S, Westall C, Dennis M, Tannock R, Sled J, Cheyne D, Campbell M. 2006-2011.
Developmental investigation of memory capacity using functional neuroimaging.
NSERC Discovery Grant, Taylor, MJ. 2009-2014, Total: $150,000; $30,000/yr .
Taylor, M.J. Structure and function in the premature brain: how to connect? Neuroradiology, 2013, 55 Suppl 2:55-64.
Duerden, E.G., Taylor, M.J., Soorya, L., Wang, T., Fan, J., Anagnostou, E. Neural correlates of response inhibition of socially relevant stimuli in adults with autism spectrum disorders. Brain Research, 2013, 1533:80-90.
Lee, W., Morgan, B.R., Shroff, M.M., Sled, J.G., Taylor, M.J. The development of regional functional connectivity in preterm infants into early childhood. Neuroradiology, 2013, 55 Suppl 2:105-11.
Duerden, E.G., Taylor, M.J., Miller, S.P. Brain development in infants born preterm: looking beyond injury. Seminars in Pediatric Neurology, 2013, 20:65-74.
Hopf, L., Quraan, M.A., Cheung, M.J., Taylor, M.J., Ryan, J.D., Moses, S.N. Hippocampal lateralization and memory in children and adults. Journal of International Neuropsychological Society, 2013, Aug 7:1-11 [Epub ahead of print].
Chau , V., Taylor, M.J., Miller, S.P. Visual function in preterm children: how MR techniques can help see the prognosis better? Documenta Ophthalmologica, 2013, 127 (1) 41-55.
Duerden EG, Card D, Roberts SW, Mak-Fan KM, Chakravarty MM, Lerch JP, Taylor MJ. Self-injurious behaviours are associated with alterations in the somatosensory system in children with autism spectrum disorders. Brain Structure & Function, april 2013, in press.
Duerden E.G., Lax, I.D., Card, D., Donner, E.J., Taylor, M.J. Alterations to frontostriatal pathways in children born very preterm. Develop Medicine Child Neurology, 2013 55(10):952-8.
Duerden, E.G. Arsalidou, M., Lee, M., Taylor, M.J. Lateralization of affective processing in the insula. Neuroimage, 2013;78:159-75
Arsalidou, M., Pascual-Leone J., Johnson J., Morris, D., Taylor, M.J. A balancing act of the brain: Activations and deactivations driven by cognitive load. Brain & Behavior, 2013, 3(3):273-85.
Bayless, S.J., Nagata, Y., Mills, T., Taylor, M.J. MEG measures of covert orienting and gaze processing in children. Brain Topography, 2013, 26(4):616-26.
Card, D., Nossin-Manor, R., Moore, A.M., Raybaud, C., Sled, J.G., Taylor, M.J. Brain metabolite concentrations associated with illness severity scores and white matter abnormalities in very preterm infants. Pediatric Research, 2013, 74(1):75-81.
Arsalidou, M., Agostino, A., Maxwell, S., Taylor, M.J. “I can read these colours” Orthographic manipulations and the development of the colour-word Stroop. Frontiers in Psychology, 2012;3:594.
Nossin-Manor R., Card, D., Morris, D., Noormohamed, S., Shroff, M.M. Whyte, H.E.A. Taylor, M.J., Sled, J.G. Quantitative MRI in the very preterm brain: Assessing tissue organization and myelination using magnetization transfer, diffusion tensor and T1 imaging. NeuroImage, 2013. 64:505-16.
Doyle-Thomas KA, Duerden EG, Taylor MJ, Lerch JP, Soorya LV, Wang AT, Fin J, Hollander E, Anagnostou E. Effects of age and symptomatology on cortical thickness in autism spectrum disorders. Research in Autism Spectrum Disorders. 2013. 7(1): 141-150.
Hung, Y., Smith, M.L. Taylor, M.J. Functional dissociation in hippocampal-prefrontal working memory systems. Cortex. 2013. 49:961-967.
Arsalidou, M., Duerden, E.G., Taylor, M.J. The centre of the brain: Topographical model of functions of the basal ganglia. Human Brain Mapping, in press, april 2012.
Doyle-Thomas KA, Kushki A, Duerden EG, Taylor MJ, Lerch JP, Soorya LV, Wang AT, Fan J, Anagnostou E. The effect of diagnosis, age, and symptom severity on cortical surface area in the cingulate cortex and insula in Autism Spectrum Disorders. Journal of Child Neurology. 2013. 28(6):729-36.
Ibrahim, G.M., Akiyama, T., Ochi, A., Otsubo, H., Smith, M.L., Taylor, M.J., Donner, E.J., Rutka, J.T., Snead, O.C., Doesburg, S.M. Disruption of Rolandic gamma-band functional connectivity by seizures is associated with motor impairments in children with epilepsy. PLoS-1, 2012; 7(6):e39326.
Lax, I.D., Duerden E.G., Chakravarty, M., Donner, E.J., Lerch, J.P., Taylor, M.J. Neuroanatomical consequences of very preterm birth in middle childhood. Brain Structure & Function, 2013. 218:575-585.
Lee W., Donner, E.J., Nossin-Manor R., Sled, J.G., Whyte H.E., Taylor M.J. Visual functional MRI of premature infants. Developmental Medicine & Child Neurology, 2012, 54(8):724-729.
Mak-Fan, K.M., Morris, D., Vidal, J., Anagnostou, E., Roberts, W., Taylor, M.J. White matter and development in children with an Autism Spectrum Disorder (ASD). Autism, 2012. doi: 10.1177/1362361312442596.
Duerden, E.G., Oatley, H.K., Mak-Fan, K.M., McGrath, P.A., Taylor, M.J. Szatmari, P., Roberts, S.W. Risk factors associated with self-injurious behaviours in children and adolescents with autism spectrum disorders. JADD, 2012 : 42(11):2460-70.
Todd, R.M., Lee, W., Evans, J.W., Lewis, M.D., Taylor, M.J. Withholding response in the face of a smile: Age-related differences in prefrontal sensitivity to Nogo cues following happy and angry faces. Developmental Cognitive Neuroscience, 2012, 2(3):340-50.
Mills, T., Lalancette, M., Moses, S.N., Taylor, M.J., Quraan, M.A. Techniques for detection and localization of weak hippocampal and frontal sources using beamformers in MEG. Brain Topography, 2012, 25, 248-263.
Nossin-Manor R., Chung, A.D., Whyte, H.E.A. Shroff, M.M. Taylor, M.J., Sled, J.G. Deep gray matter maturation in very preterm neonates: Regional Variations and pathology-related age-dependent changes in Magnetization Transfer Ratio. Radiology, 2012, 263(2):510-517.
Latinus, M. Taylor, M.J. Discriminating male and female voices: differentiating pitch and gender. Brain Topography, 2012, 25(2):194-204.
Duerden, E.G., Mak-Fan, K.M., Oatley, H.K., Taylor, M.J. Roberts, S.W. Regional differences in grey and white matter in children and adults with Autism Spectrum Disorder: an ALE meta-analysis. Autism Research, 2012, 5(1):49-66.
Mak-Fan, K.M., Taylor, M.J., Roberts, W., Lerch, J.P. Measures of cortical grey matter structure and development in children with Autism Spectrum Disorder. J. Autism & Developmental Disorders, 2012, 42(3): 419-27.
Vidal, J., Mills, T., Pang, E.W., Taylor, M.J. Response inhibition in adults and teenagers: Spatiotemporal differences in the prefrontal cortex. Brain & Cognition, 2012, 79, 49–59.
Nagata, Y., Bayless, S.J., Mills, T., Taylor, M.J. Spatio-temporal localisation of attentional orienting to gaze and peripheral cues. Brain Research, 2012, 1439:44-53.
Hung, Y., Smith, M.L., Taylor, M.J. Development of ACC-amygdala activations in processing unattended fear. Neuroimage, 2012, 60, 545-552.
Taylor, M.J. Donner, E.J., Pang, E.W. fMRI and MEG in the study of typical and atypical cognitive development. Clinical Neurophysiology, 2012, 42, 19-25.
Kadis, D.S., Pang, E.W., Mills, T., Taylor, M.J., McAndrews, M.P., Smith M.L. Characterizing the normal developmental trajectory of expressive language lateralization using magnetoencephalography. Journal of the International Neuropsychology Society, 2011, 17, 896-904
Taylor, M.J., Mills, T., Pang, E.W. The development of face recognition; hippocampal and frontal lobe contributions determined with MEG. Brain Topography. 2011, (3-4), 261-70.
Anagnostou, E., Taylor, M.J. Review of neuroimaging in ASD: what have we learned and where do we go from here. Molecular Autism, 2011, 2:4.
Batty, M., Meaux, E., Wittemeyer, K. Rogé, B., Taylor, M.J. Early processing of emotional faces in children with autism. J. Exp. Child Psychology. 2011: 109(4):430-44.
Arsalidou, M., Morris, D. Taylor, M.J. Converging evidence on the advantage of dynamic facial expressions. Brain Topography, 2011, 2(2), 149-163.
Taylor, M.J., Bayless, S.J, Mills, T., Pang, E.W. Recognising upright and inverted faces: MEG source localisation. Brain Research, 2011, 1381:167-74.
Arsalidou, M., Taylor, M.J. Does 2 + 2 = 4? Meta-analyses of brain areas needed for numbers and calculations. NeuroImage. 2011 ; 54(3):2382-2393.
Bayless, S.J., Glover, M., Taylor, M.J., Itier R.J. Is it in the eyes? Dissociating the role of emotion and perceptual features of emotionally expressive faces in modulating orienting to eye-gaze. Visual Cognition, 2011, 19 (4), 483-510.
Morris D., Nossin-Manor R., Taylor M.J., Sled J.G. Outlier correction prior to registration improves diffusion tensor estimates in preterm DTI data. Magnetic Resonance in Medicine, 2011. 66:92-101.
Nossin-Manor R., Chung, A.D., Morris, D., Soares-Fernandes, J.P, Thomas, B. Cheng, H-L., Whyte, H.E.A., Taylor, M.J., Sled, J.G, Shroff, M.M. Optimized T1 and T2 weighted volumetric brain imaging as a diagnostic tool in very preterm neonates. Pediatric Radiology, 2011. 41(6). 702-710.
Beal, D.S., Quraan, M.A., Cheyne, D.O., Taylor, M.J., Gracco V.L., De Nil. L.F. Speech-induced suppression of evoked auditory fields in children who stutter. Neuroimage, 2011; 54(4):2994-3003.
Todd, R.M., Evans, J.W., Morris, D., Lewis, M.D., Taylor, M.J. The changing face of emotion: Age related patterns of amygdala activation to salient faces. Social Cognitive & Affective Neuroscience, 2011 6: 12-23
Misic, B.V., Mills, T. Taylor, M.J., McIntosh, A.R. Brain noise is task-dependent and region-specific. J. of Neurophysiology, 2010, 104(5):2667-76.
Arsalidou, M., Barbeau, E.J., Bayless, S.J., Taylor, M.J. Brain responses differ to faces of mothers and fathers. Brain and Cognition, 2010, 74(1):47-51.
Sun, F., Morris, D., Lee, W., Taylor, M.J., Mills, T, Babyn, P.S. Feature-space-based fMRI analysis using the Optimal Linear Transformation. IEEE Trans. Information Techn. in BioMedicine, 2010, 14(3), 1279-1290.
Beal, D.S., Cheyne, D.O., Gracco V.L., Quraan, M.A., Taylor, M.J., De Nil, L.F. Auditory evoked responses to vocalization during passive listening and active generation in adults who stutter. NeuroImage, 2010, 52(4):1645-53.
Latinus, M., VanRullen, R. Taylor, M.J. Top-down and bottom-up attentional modulation in processing bimodal face/voice stimuli. BMC Neuroscience, 2010, 11:36 doi: 10.1186/1471-2202-11-36.
Hung Y.I., Smith, M.L, Bayle, D.J., Mills, T., Cheyne, D.O., Taylor, M.J. Unattended fear elicits early frontal-amygdala and fusiform activations. NeuroImage, 2010, 50, 727–733.
Bayle, D.J., Taylor, M.J. Attention inhibition of early cortical activation to fearful faces. Brain Research, 2010, 1313, 113-123.
Evans, J.W., Todd, R.M., Taylor, M.J. Strother, S.C. Group specific optimisation of fMRI processing steps for child and adult data. NeuroImage, 2010, 50, 479–490.
Séverac Cauquil, A., Delaux, S., Lestringant, R., Taylor, M.J. Trotter, Y. Neural correlates of chromostereopsis: an evoked potential study. Neuropsychologia, 2009, 47, 2677–2681.
Taylor, M.J. Pang, E.W. Using MEG to image cognition in children. Down Syndrome Quarterly, 2009, 11: 10-17.
Taylor, M.J., Arsalidou, M., Bayless, S.J., Morris, D., Evans, J.W. Barbeau, E.J. Neural correlates of personally familiar faces: Parents, partner and own faces. Human Brain Mapping, 2009, 30, 2008-2020.
Taylor, M.J., Mills T., Smith, M.L, Pang E.W. Face processing in adolescents with and without epilepsy. International Journal of Psychophysiology, 2008, 68, 94-103.
Barbeau EJ, Taylor MJ, Regis J, Marquis P, Chauvel P, Liégeois-Chauvel C. Spatio-temporal dynamics of face recognition. Cerebral Cortex, e-pub, Aug. 22nd, 2007.