About Sickkids
About SickKids

Greg D. Wells, PhD

Research Institute
Associate Scientist
Physiology & Experimental Medicine

University of Toronto
Assistant Professor
Faculty of Physical Education and Health

Assistant Professor
Anesthesia, Faculty of Medicine

Phone: 416-978-3244
e-mail: greg.wells@sickkids.ca

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Brief Biography

Dr. Greg Wells is currently an Assistant Professor at the Faculty of Physical Education and Health and in the Department of Anaesthesia at the University of Toronto. He is also an associate scientist in Physiology & Experimental Medicine at The Hospital for Sick Children. As a researcher, Wells is working in a field of investigation called exercise medicine, where he uses specific exercise protocols to test the limitations of the human body in various diseases – mostly related to muscle and lung conditions. He has been using advanced MRI technologies to measure these limitations, as MRI does not require any radiation or drugs and can offer a look inside the human body without the use of needles or other invasive measures.

Research Interests

Physical activity, fitness and health outcomes are strongly related, especially in children with chronic disease. Chronically ill children often suffer from exercise intolerance, have poor fitness, participate in fewer activities, spend less time exercising and they are often deconditioned. Fortunately, exercise and physical activity may attenuate chronic disease and its associated disability. Therefore the objectives of Wells' research program are 1) to determine the physiological mechanisms of exercise intolerance in patients with chronic disease and to test our Impaired Perfusion and Muscle Metabolism hypotheses and 2) to develop a knowledge base for evidence-based specific exercise and activity interventions. To accomplish this he uses traditional exercise testing, and also non-invasive magnetic resonance spectroscopy and imaging techniques to investigate the pathophysiology of exercise intolerance in children with chronic disease.


E Jean-St-Michel, C Manlhiot, J Li, M Tropak, MM Michelsen, MR Schmidt, BW McCrindle, GD Wells, AN Redington (co-Sr. Author). Remote ischaemic preconditioning improves maximal performance in elite athletes. Medicine and Science in Sports and Exercise. 2011 Jul;43(7):1280-6.

Wells GD, Wilkes D, Selvadurai, H. Schneiderman, JE, Elmi M, Dell S, Lands L, Ratjen F, Coates A. Skeletal muscle abnormalities in cystic fibrosis. Pediatric Research. 2011 Jan;69(1):40-5.

Vescovi JD, Falenshuk, O, Wells GD. Factors affecting blood lactate accumulation and clearance in elite competitive swimmers during competition. International Journal of Sports Physiology and Performance. Mar;6(1):106-17.

Balaban D, Preiss D, Mardimae A, Slessarev M, Wells, GD, Duffin, J, Iscoe S, Fisher JA. Evaluation of a simple breathing circuit designed for home Ventilatory Muscle Endurance Training. Respiratory Medicine. Respir Med. 2009 Dec;103(12):1822-7.

Wilkes D, Schneiderman-Walker J, Coates, A, Wells GD. Exercise and physical activity in children with cystic fibrosis. Pediatric Respiratory Reviews. 2009 Sep;10(3):105-9.

Wells GD, Tein I, Selvadurai H. Bioenergetic provision of energy for muscular activity. Pediatric Respiratory Reviews. 2009 Sep;10(3):83-90.

Wells GD, Norris, S. Assessment of physiological capacities of elite athletes & respiratory limitations to exercise performance. Pediatric Respiratory Reviews. 2009 Sep;10(3):91-8.

Wells GD, Elmi M, Thomas S. Physiological correlates of performance in golf. Journal of Strength and Conditioning Research. 2009 May;23(3):741-50.

Wells GD, Heale L, Wilkes D, Schneiderman-Walker, J., Ratjen F, Coates A. Assessment of Body Composition in Paediatric Patients with Cystic Fibrosis. Pediatric Pulmonology. 2008 Oct;43(10):1025-32.

Ito S, Mardimae A, Han J, Duffin J, Fedorko L, Minkovich L, Katznelson R, Meineri M, Mrenovich A, Wells G, Kessler C, Fisher J. Non-invasive prospective targeting of arterial PCO2 in subjects at rest. Journal of Physiology. 2008 Aug 1;586(Pt 15):3675-82.

Wells GD, Noseworthy MD, Tarnopolsky M, Hamilton J, Tein, I. Skeletal muscle metabolic dysfunction in obesity and metabolic syndrome. Canadian Journal of Neurological Sciences. 2008 Mar;35(1):31-40.

Wells GD, Wilkes D, Schneiderman-Walker, J., Elmi M, Tullis E, Lands L, Ratjen F, Coates A. Reliability and validity of the habitual activity estimation scale (HAES) in patients with cystic fibrosis. Paediatric Pulmonology. 2008 Apr;43(4):345-53.

Wells GD, Duffin J. Frequency of movements and respiratory control in exercise. Respiratory Physiology Neurobiology. 2008 Feb 7.

Wells GD, Diep T, Duffin J. The ventilatory response to sine wave variation in exercise loads and limb movement frequency. Respiratory Physiology and Neurobiology. 2007 Aug 15;158(1):45-50.

Wells GD, Schneiderman-Walker J, Plyley M. Normal physiological characteristics of elite swimmers. Pediatric Exercise Science. 2006 17: 30-52.

Wells GD, Plyley M, Thomas S, Goodman L, Duffin J. Effects of concurrent inspiratory and expiratory muscle training on respiratory and exercise performance in competitive swimmers. European Journal of Applied Physiology. 2005 94(5-6): 527-40.