Long term post-transplant risk of malignancy in childhood recipients of solid organ transplants
A high incidence of post-transplant malignancies in solid organ transplant recipients has become increasingly evident with improved short-term recipient and graft outcomes, and contributes significantly to recipients’ overall long-term morbidity and mortality.
However, very limited paediatric data regarding excess cancer risk following childhood solid organ transplantation exists. Hence, we propose to study the excess long term absolute risk and relative risk of cancer in to adulthood, of childhood recipients of solid organ transplants. It is anticipated that the results from this study will:
i)increase understanding of paediatric recipients` future cancer risk
ii) improve pre and post-transplant recipient counseling of risk
iii) stimulate appropriate screening development to facilitate early intervention and improved outcomes.
This presentation will outline the research proposal.
Dr. Rebecca Spicer, Clinical Fellow
Rebecca has been a Clinical Fellow in Paediatric Nephrology for 18 months at Hospital for Sick Children, Toronto, and started her Masters degree in Clinical Epidemiology and Health Care Research in July 2012 at University of Toronto.
Dr. Rulan Parekh, Sr. Associate Scientist, CHES