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Translational Medicine Research in Progress Seminar
Start date:
Wednesday, April 4, 2018
Noon to 1 p.m.
Peter Gilgan Centre for Research and Learning, Room 09.9701 (9th floor)

Join the Translational Medicine Research Program at the SickKids Research Institute for a Translational Medicine Research in Progress seminar.

Speakers: Santyr Lab, Marcus Couch, PhD and Brandon Zanette, M.Sc.

Topic: Imaging the Pediatric Lung using Hyperpolarized 129Xe MRI: Mapping of Ventilation and Gas Exchange

Hyperpolarized 129Xe magnetic resonance imaging (MRI) is a powerful, emergent tool for mapping regional lung function in pediatric lung diseases, including cystic fibrosis, asthma, lung injury and bronchopulmonary dysplasia. Hyperpolarized 129Xe MRI is well tolerated in children, reproducible and can be performed longitudinally without the need for ionizing radiation. 

In this presentation, we will describe our preliminary studies using this approach in adults and children at SickKids, including cystic fibrosis patients. We will describe a typical imaging protocol, along with dosing and reproducibility considerations. From single breath-hold 129Xe images, we calculate the fraction of unventilated lung, and correlate these results with physiological parameters. It is also possible to perform multiple breath imaging of the washout of hyperpolarized 129Xe from the lungs to probe gas replacement dynamics and map regional ventilation. In addition, 129Xe is soluble in blood and tissue, and we are able to probe the 129Xe uptake across the blood/gas barrier. 

Overall, hyperpolarized 129Xe MRI biomarkers are expected to provide sensitive regional outcome measures that can be used in disease surveillance as well as interventional studies.

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