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Centre for Global Child Health

Effect of prenatal vitamin D supplementation on placental growth and angiogenesis

Principal investigator, Dr. Daniel Roth, Scientist at the Centre for Global Child Health and Child Health Evaluative Sciences, Staff Physician of Paediatric Medicine at The Hospital for Sick Children (SickKids), Assistant Professor, Institute of Health Policy, Management & Evaluation at the University of Toronto.

This project is a sub-study of the Maternal Vitamin D for Infant Growth (MDIG) Trial. The study aims to compare placental weight and newborn weight among the arms of the MDIG Trial to determine the impact of vitamin D supplementation and investigate the effects of dose on placenta development.
Measurement of key regulatory molecules of placental angiogenesis will help to clarify the mechanisms by which Vitamin D supplementation affects placental development. Imaging of placental tissue will be used to generate information on structural changes and tissue-specific angiogenic factor expression alterations in response to vitamin D supplementation.

Project collaborators include International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), Penn State University