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Centre for Global Child Health

Epigenetic regulation of vitamin D signaling and infant growth

Principal investigator: Dr. Daniel Roth, Scientist at the Centre for Global Child Health and Child Health Evaluative Sciences, Staff Physician of Paediatric Medicine at The Hospital for Sick Children (SickKids), Assistant Professor, Institute of Health Policy, Management & Evaluation at the University of Toronto.

This project is sub study of the Maternal Vitamin D for Infant Growth (MDIG) Trial. The primary aim is to clarify how prenatal vitamin D supplementation affects epigenetic regulation (methylation pattern) of vitamin D and bone growth related genes. Through this project, information on epigenetic regulation will be available for 850,000 genes in 24 mother-infant pairs of the MDIG Trial.

Project collaborators include International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)