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Centre for Global Child Health

Molecular mechanisms of Vitamin D effects on infant growth

Principal investigator: Dr. Daniel Roth, Scientist at the Centre for Global Child Health and Child Health Evaluative Sciences, Staff Physician of Paediatric Medicine at The Hospital for Sick Children (SickKids), Assistant Professor, Institute of Health Policy, Management & Evaluation at the University of Toronto.

This project is a sub-study of the Maternal Vitamin D for Infant Growth (MDIG) Trial. The aim of this study is to quantify a number of growth hormones, regulatory molecules and inflammatory markers in maternal and infant blood to gain insight into the mechanism by which Vitamin D influences infant growth.

Several potential biomarkers of growth and bone development are being tested in plasma samples collected from mothers and infants participating in the MDIG Trial, including:

  • Various splice variants of the parathyroid hormone (PTH)
  • Growth factors, such as Insulin-like growth factor (IGF)-1 and -2 , their receptors (IGFBP-1 and -3) and fibroblast growth factor (FGF)-21 and -23
  • Inflammatory markers, such as IL-6 and CRP

*Laboratory work is underway.

Project collaborators include International Centre for Diarrheal Disease Research, Bangladesh (icddr,b).