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Centre for Global Child Health

Randomized Placebo-controlled Trial of Maternal Vitamin D Supplementation During Pregnancy and Lactation to Improve Infant Linear Growth in Dhaka, Bangladesh

Principal Investigator: Dr. Daniel Roth, Scientist at the Centre for Global Child Health and Child Health Evaluative Sciences, Staff Physician of Paediatric Medicine at The Hospital for Sick Children (SickKids), Assistant Professor, Institute of Health Policy, Management & Evaluation at the University of Toronto.

The Maternal Vitamin D for Infant Growth (MDIG) Trial is a randomized controlled trial conducted in Bangladesh, investigating the effects of various doses of vitamin D in the prenatal or post-partum period on infant linear growth. A total of 1,300 women are recruited during the second trimester (17-24 week) of their pregnancy, who receive one of the four vitamin D doses or placebo during their pregnancy and for six months post-partum. Mothers and their infants are followed up until the children, who are born in the trial, turn two years of age. 

The primary outcome is infant length at one years of age. In addition, the trial will include analyses of inflammatory and hormonal determinants of infant growth, epigenetic phenomena (processes modifying  gene expression, helping organisms to adapt to the environment without changing the genome) that affect vitamin D metabolism and diarrheal and respiratory morbidity in infants. Detailed health data and biological specimen are also collected from the participants.

Publication: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499946/

The results of this trial were published on August 9, 2018 in The New England Journal of Medicine

Learn more about the trial.

Project collaborators include International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), University of Toronto, Penn State University.



Molecular mechanisms of Vitamin D effects on infant growth

Effect of prenatal vitamin D supplementation on placental growth and angiogenesis

Epigenetic regulation of vitamin D signaling and infant growth

Effects of Vitamin D on toxic heavy metal levels in pregnant women in Dhaka, Bangladesh