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Paediatric Laboratory Medicine

Apolipoprotein B

Clinical Significance

Apolipoprotein B is the main protein component of LDL(low density lipoprotein), VLDL (very low density lipoprotein) and chylomicrons. ApoB is necessary for the reaction with LDL receptors in the liver and on cell walls and is involved in transporting cholesterol from the liver to vascular epithelial cells. Elevated levels of ApoB are frequently found in patients with atherosclerotic vascular changes and are a risk factor for atherosclerosis. Severely decreased levels of circulating ApoB are associated with fat malabsorption, acanthocytosis, retinitis pigmentosa, and neuromuscular degeneration. Several studies have shown that apolipoproteins A1 and B levels are useful in assessing the risk of atherosclerosis and have greater predictive value than the determination of HDL and LDL cholesterol levels alone. The ApoB / ApoA1 ratio is an additional parameter for estimating the risk of atherosclerosis: the higher the ratio, the greater the risk.

Test Name

Apolipoprotein B

Alternate Name/ Synonym


Test Code



Biochemistry- Test Development Multiplex


Automated Analyzer

Turn Around Time

Batch testing (50 samples)


Cardiac Risk

Specimen Type

Serum or EDTA Plasma

Minimum Specimen Requirements

150 uL


Send frozen

Special Requirements

* For research purposes only.

Approval is required

CPT Codes


Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Phone: 416-813-7200
Phone: 1-855-381-3212

Reference Range

0 - 14 days: 0.09 - 0.67 g/L
15 days - <1 yr: 0.19 - 1.23 g/L
1 yr - <6 yrs: 0.41 - 0.93 g/L
6 yrs - <19 yrs: 0.31 - 0.84 g/L