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Paediatric Laboratory Medicine

cGMP

Clinical Significance

cGMP is a second messenger that produces its effects by interacting with intracellular receptor proteins. In smooth muscle cells, one of the major receptors for cGMP is the serine/threonine protein kinase, cGMP-dependent protein kinase (PKG). PKG has been shown to catalyze the phosphorylation of a number of physiologically relevant proteins whose function it is to regulate the contractile activity of the smooth muscle cell.

Test Name

cGMP

Alternate Name/ Synonym

Cyclic Guanosine Monophosphate

Test Code

RD032

Division

Biochemistry- Test Development Multiplex

Method

ELISA

Turn Around Time

Batch testing (37 samples)

Specimen Type

EDTA Plasma only

Minimum Specimen Requirements

200 uL of Plasma

Storage/Transportation

Collect send to Lab in ice. Separate plasma immediatley. Plasma store in -20°C and send frozen.

Special Requirements

* For research purposes only.

Approval is required

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212