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Paediatric Laboratory Medicine


Clinical Significance

cGMP is a second messenger that produces its effects by interacting with intracellular receptor proteins. In smooth muscle cells, one of the major receptors for cGMP is the serine/threonine protein kinase, cGMP-dependent protein kinase (PKG). PKG has been shown to catalyze the phosphorylation of a number of physiologically relevant proteins whose function it is to regulate the contractile activity of the smooth muscle cell.

Test Name


Alternate Name/ Synonym

Cyclic Guanosine Monophosphate

Test Code



Biochemistry- Test Development Multiplex



Turn Around Time

Batch testing (37 samples)

Specimen Type

EDTA Plasma only

Minimum Specimen Requirements

200 uL of Plasma


Collect send to Lab in ice. Separate plasma immediatley. Plasma store in -20°C and send frozen.

Special Requirements

* For research purposes only.

Approval is required

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Phone: 416-813-7200
Phone: 1-855-381-3212