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Paediatric Laboratory Medicine

Tobramycin

Clinical Significance

Tobramycin is one of the aminoglycoside class of bactericidal drugs, also including streptomycin, neomycin, netilmycin, sisomycin, gentamicin, kanamycin, and amikacin. Due to toxic effects associated with aminoglycosides manifest as delayed-onset vestibular and cochlear sensory cell destruction and acute renal tubular necrosis, the goal of monitoring is to maintain therapeutic plasma concentration at minimum risk to patients.

Test Name

Tobramycin

Test Code

TOBTR, TOBPK, TOBSP

Drug Class

Antibiotics

Division

Therapeutic Drug Monitoring - TDM

Method

Vitros Fusion 5.1

External Proficiency Testing

QMPLS, CAP

Turn Around Time

Daily (throughout the day)

Disease/Condition

Antibiotic

Specimen Type

Serum, Plasma (Heparin)

Minimum Specimen Requirements

150 uL

Optimal Collection Time

Trough: 0-30 minutes prior to dose 
Peak: 30-60 minutes after finish

Storage/Transportation

4°C (transport with a cool pack if possible)

Approval is not required

CPT Codes

80200

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

Trough: 0.6 - 2.0 mg/L 
Peak: 5.0 - 10.0 mg/L

Critical Values

Trough: > 2.0 mg/L 
Peak: > 10.0 mg/L