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Paediatric Laboratory Medicine

Valproic Acid (Total)

Clinical Significance

Valproic Acid is used in the treatment of patients with complex partial seizures which occur either alone or in association with other types of seizures. Valproic acid may be used solely or in combination with other anticonvulsant drugs. The capability of treating many different types of seizures has resulted in the wide-spread use of valproic acid, particularly in children. Most patients receiving valproic acid do not develop a tolerance to its anticonvulsant effects. Valproic acid is generally well tolerated, with the most common side effects being: headache, gastrointestinal (nausea, vomiting,diarrhea), nervous system (tremors) and thrombocytopenia.

Test Name

Valproic Acid (Total)

Alternate Name/ Synonym

Depakene

Test Code

VAP

Drug Class

Anticonvulsants

Division

Therapeutic Drug Monitoring - TDM

Method

Abbott Architect ci4100

External Proficiency Testing

CAP
QMPLS

Turn Around Time

Daily @ 14:00h

Disease/Condition

Anticonvulsant

Specimen Type

Serum, Plasma (Heparin, Citrate or EDTA)

Minimum Specimen Requirements

150 uL

Optimal Collection Time

Trough: 0 - 30 minutes prior to dose

Storage/Transportation

4°C (transport with a cool pack if possible)

Approval is not required

CPT Codes

80164

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

350 - 700 umol/L

Critical Values

> 1000 umol/L