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Paediatric Laboratory Medicine

Voriconazole

Clinical Significance

Voriconazole is used to treat serious fungal infections such as invasive aspergillosis and esophageal candidiasis. Voriconazole is in a class of antifungal medications called triazoles which work by slowing the growth of the fungi that cause infection.

Test Name

Voriconazole

Alternate Name/ Synonym

Vfend

Test Code

VORI

Drug Class

Anti-fungal

Division

Therapeutic Drug Monitoring - TDM

Method

LC-MS/MS

External Proficiency Testing

KKGT - Netherlands (Association for Quality Assessment in Therapeutic Drug Monitoring and Clinical Toxicology)

Turn Around Time

Daily (Monday to Friday @ 09:00)

Disease/Condition

Anti-fungal

Specimen Type

Plasma (Heparin)

Minimum Specimen Requirements

250 uL

Optimal Collection Time

Trough: 0 - 30 minutes prior to dose

Storage/Transportation

Same day: 4°C (transport with a cool pack if possible), Next Day: -20°C (transport on dry ice)

Approval is not required

CPT Codes

80299

Shipping and Contact Information

The Hospital for Sick Children
Rapid Response Laboratory
170 Elizabeth Street, Room 3642
Toronto, ON
M5G 2G3
Canada
Phone: 416-813-7200
Phone: 1-855-381-3212

Therapeutic Range

Trough: 1.0 to 5.0 mg/L

Critical Values

> 6.0 mg/L